Zobrazeno 1 - 10
of 1 081
pro vyhledávání: '"David J, Brooks"'
Autor:
Kristian Juul-Madsen, Peter Parbo, Rola Ismail, Peter L. Ovesen, Vanessa Schmidt, Lasse S. Madsen, Jacob Thyrsted, Sarah Gierl, Mihaela Breum, Agnete Larsen, Morten N. Andersen, Marina Romero-Ramos, Christian K. Holm, Gregers R. Andersen, Huaying Zhao, Peter Schuck, Jens V. Nygaard, Duncan S. Sutherland, Simon F. Eskildsen, Thomas E. Willnow, David J. Brooks, Thomas Vorup-Jensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer’s Disease is commonly preceded by a prodromal period. Here, we rep
Externí odkaz:
https://doaj.org/article/81c39ad41509420b82e48e637c1da445
Autor:
Hilmar P. Sigurdsson, Lisa Alcock, Michael Firbank, Ross Wilson, Philip Brown, Ross Maxwell, Elizabeth Bennett, Nicola Pavese, David J. Brooks, Lynn Rochester
Publikováno v:
NeuroImage, Vol 288, Iss , Pp 120531- (2024)
Gait is an excellent indicator of physical, emotional, and mental health. Previous studies have shown that gait impairments in ageing are common, but the neural basis of these impairments are unclear. Existing methodologies are suboptimal and novel p
Externí odkaz:
https://doaj.org/article/c096ef344398443a92479200422bd187
Autor:
Jacob Horsager, Niels Okkels, Nathalie Van Den Berge, Jan Jacobsen, Anna Schact, Ole Lajord Munk, Kim Vang, Dirk Bender, David J. Brooks, Per Borghammer
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Background The autonomic nervous system is frequently affected in some neurodegenerative diseases, including Parkinson’s disease and Dementia with Lewy bodies. In vivo imaging methods to visualize and quantify the peripheral cholinergic ne
Externí odkaz:
https://doaj.org/article/dea18ac0e9764365a8f638a14a74f226
Publikováno v:
Brain Stimulation, Vol 16, Iss 1, Pp 394-395 (2023)
Externí odkaz:
https://doaj.org/article/d44686ff309e4b20b3edd8807fa50c15
Autor:
Grazia Daniela Femminella, Nicholas R. Livingston, Sanara Raza, Thalia van der Doef, Eleni Frangou, Sharon Love, Gail Busza, Valeria Calsolaro, Stefan Carver, Clive Holmes, Craig W. Ritchie, Robert M. Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben Underwood, Aparna Prasanna, Paul Koranteng, Salman Karim, Kehinde Junaid, Bernadette McGuinness, Anthony Peter Passmore, Ramin Nilforooshan, Ajayverma Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, Tricia Tan, Christian Holscher, John Harrison, David J. Brooks, Clive Ballard, Paul Edison
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Background Type 2 diabetes is a risk factor for Alzheimer’s disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we
Externí odkaz:
https://doaj.org/article/a198863d79fc4206ad26cdc93baa3fb5
Autor:
Rola Ismail, Peter Parbo, Lasse Stensvig Madsen, Allan K. Hansen, Kim V. Hansen, Jeppe L. Schaldemose, Pernille L. Kjeldsen, Morten G. Stokholm, Hanne Gottrup, Simon F. Eskildsen, David J. Brooks
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-11 (2020)
Abstract Background The aim of this longitudinal study was to assess with positron emission tomography (PET) the relationship between levels of inflammation and the loads of aggregated β-amyloid and tau at baseline and again after 2 years in prodrom
Externí odkaz:
https://doaj.org/article/d6cbb349346a47e69fbe4d108ae94551
Autor:
Peter Parbo, Lasse Stensvig Madsen, Rola Ismail, Henrik Zetterberg, Kaj Blennow, Simon F. Eskildsen, Thomas Vorup-Jensen, David J. Brooks
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-7 (2020)
Abstract Background Plasma and cerebrospinal fluid levels of neurofilament light (NfL), a marker of axonal degeneration, have previously been reported to be raised in patients with clinically diagnosed Alzheimer’s disease (AD). Activated microglia,
Externí odkaz:
https://doaj.org/article/e074fe041f254675a330d994a13e4f4b
Autor:
Lasse S. Madsen, Rune B. Nielsen, Peter Parbo, Rola Ismail, Irene K. Mikkelsen, Hanne Gottrup, Leif Østergaard, David J. Brooks, Simon F. Eskildsen
Publikováno v:
Aging Brain, Vol 2, Iss , Pp 100035- (2022)
Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, w
Externí odkaz:
https://doaj.org/article/7c197089d395425ab1fc07797aaaeb63
Autor:
Pernille L. Kjeldsen, Peter Parbo, Kim V. Hansen, Joel F.A. Aanerud, Rola Ismail, Peter H. Nissen, Rikke B. Dalby, Malene F. Damholdt, Per Borghammer, David J. Brooks
Publikováno v:
Aging Brain, Vol 2, Iss , Pp 100048- (2022)
Introduction: The typical spatial pattern of amyloid-β (Aβ) in diagnosed Alzheimer’s disease (AD) is that of a symmetrical hemispheric distribution. However, Aβ may be asymmetrically distributed in early stages of AD. Aβ distribution on PET has
Externí odkaz:
https://doaj.org/article/d4f233cd10d145528054e34755010fb9
Autor:
Grazia Daniela Femminella, Eleni Frangou, Sharon B. Love, Gail Busza, Clive Holmes, Craig Ritchie, Robert Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben R. Underwood, Aparna Prasanna, Paul Koranteng, Salman Karim, Kehinde Junaid, Bernadette McGuinness, Ramin Nilforooshan, Ajay Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, John Harrison, David J. Brooks, Anthony Peter Passmore, Clive Ballard, Paul Edison
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue currently approved for type 2 diabetes and obesity. Preclinical evidence in transgenic models of Alzheimer’s disease suggests that liraglutide exerts neuroprotective effe
Externí odkaz:
https://doaj.org/article/3a0e309bbdd6411c977edcbdc27ca743