Zobrazeno 1 - 10
of 529
pro vyhledávání: '"David J, Baylink"'
Autor:
Huynh Cao, Jeffrey Xiao, David J. Baylink, Vinh Nguyen, Nathan Shim, Jae Lee, Dave J. R. Mallari, Samiksha Wasnik, Saied Mirshahidi, Chien-Shing Chen, Hisham Abdel-Azim, Mark E. Reeves, Yi Xu
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2250 (2024)
Background: T-cell-based adoptive cell therapies have emerged at the forefront of cancer immunotherapies; however, failed long-term survival and inevitable exhaustion of transplanted T lymphocytes in vivo limits clinical efficacy. Leukemia blasts pos
Externí odkaz:
https://doaj.org/article/ebb1a91ed9ef452bb180d39522240859
Publikováno v:
Cells, Vol 13, Iss 17, p 1465 (2024)
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestines without a cure. Current therapies suppress inflammation to prevent further intestinal damage. However, healing already damaged intestinal epithelia is still an unme
Externí odkaz:
https://doaj.org/article/4757275f462345dd8c3f153810a4a7a9
Autor:
Yi Xu, David J. Baylink, Jeffrey Xiao, Lily Tran, Vinh Nguyen, Brandon Park, Ismael Valladares, Scott Lee, Kevin Codorniz, Laren Tan, Chien-Shing Chen, Hisham Abdel-Azim, Mark E. Reeves, Hamid Mirshahidi, Guido Marcucci, Huynh Cao
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8532 (2024)
Acute myeloid leukemia (AML) has a poor survival rate for both pediatric and adult patients due to its frequent relapse. To elucidate the bioenergetic principle underlying AML relapse, we investigated the transcriptional regulation of mitochondrial
Externí odkaz:
https://doaj.org/article/1dc10d5d103c4f7e84157a86199a5ee0
Autor:
Yi Xu, David J. Baylink, Chien-Shing Chen, Laren Tan, Jeffrey Xiao, Brandon Park, Ismael Valladares, Mark E. Reeves, Huynh Cao
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Acute myeloid leukemia (AML) patients have frequent mutations in FMS-like receptor tyrosine kinase 3 (FLT3-mut AML), who respond poorly to salvage chemotherapies and targeted therapies such as tyrosine kinase inhibitors (TKIs). Disease relapse is a c
Externí odkaz:
https://doaj.org/article/04222e2a69dc42e88e95be578473bd6b
Autor:
Yi Xu, Christopher Hino, David J. Baylink, Jeffrey Xiao, Mark E. Reeves, Jiang F. Zhong, Saied Mirshahidi, Huynh Cao
Publikováno v:
Biomarker Research, Vol 10, Iss 1, Pp 1-5 (2022)
Abstract Acute myeloid leukemia (AML) has the lowest survival rate among the leukemias. Targeting intracellular metabolism and energy production in leukemic cells can be a promising therapeutic strategy for AML. Recently, we presented the successful
Externí odkaz:
https://doaj.org/article/f736b737ff18458391da2cc5d0a70964
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Understanding the factors which shape T-lymphocyte immunity is critical for the development and application of future immunotherapeutic strategies in treating hematological malignancies. The thymus, a specialized central lymphoid organ, plays importa
Externí odkaz:
https://doaj.org/article/3fe6b2fa0454464c816cdc5d965407f6
Autor:
Huynh Cao, Do Hyun Kim, Ashley Howard, Hector Moz, Samiksha Wasnik, David J. Baylink, Chien-Shing Chen, Mark E Reeves, Saied Mirshahidi, Jeffrey Xiao, Olivia Francis, Guido Marcucci, Yi Xu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1252-1260 (2021)
T cell based immunotherapies can be applicable to acute myeloid leukemia (AML). Therefore, the selection of optimal T cells, cell manufacturing, and therapeutic T cell engineering are essential for the development of effective adoptive T cell therapi
Externí odkaz:
https://doaj.org/article/207d9563c96c4f869249a88fd26308d6
Autor:
Yi Xu, David J. Baylink, Chien-Shing Chen, Mark E. Reeves, Jeffrey Xiao, Curtis Lacy, Eric Lau, Huynh Cao
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to a declaration of a Public Health Emergency of International Concern by the World Health Organization. As of May 18, 2020, there have been more than 4.7 million cases and over 316,00
Externí odkaz:
https://doaj.org/article/a4a0ae00c1a74bb3b68ac3b3337a2ad5
Autor:
Huynh Cao, Jeffrey Xiao, Mark E. Reeves, Kimberly Payne, Chien Shing Chen, David J. Baylink, Guido Marcucci, Yi Xu
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-4 (2020)
Abstract Here, we report a unique acute myeloid leukemia (AML) bone marrow-derived mesenchymal stem cell (MSC) with both mesenchymal and endothelial potential, which we have named Mesenchymal Cancer Stem Cells (MCSCs). These MCSCs are CD90-CD13-CD44+
Externí odkaz:
https://doaj.org/article/0e82795f0dfb412d9904bec2447fef6f
Autor:
Chih-Huang Li, Xiaolei Tang, Samiksha Wasnik, Xiaohua Wang, Jintao Zhang, Yi Xu, Kin-Hing William Lau, H. Bryant Nguyen, David J. Baylink
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Vitamin D deficiency, determined by blood levels of 25-hydroxyvitamin D [25(OH) D, i.e. the major vitamin D form in blood], has been shown to associate with all-cause mortalities. We recently demonstrated that blood levels of 1,25
Externí odkaz:
https://doaj.org/article/91ab2ded21b148b596b916155e69518f