Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David Inman"'
A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells
Autor:
Bong Hwan Sung, Ariana von Lersner, Jorge Guerrero, Evan S. Krystofiak, David Inman, Roxanne Pelletier, Andries Zijlstra, Suzanne M. Ponik, Alissa M. Weaver
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
A prior live-cell exosome reporter showed dim fluorescence and could not be expressed stably, limiting its usefulness. Here the authors stabilise the reporter to allow long-term tracking of exosomes, and incorporate a second fluorophore to visualise
Externí odkaz:
https://doaj.org/article/a92f2f1ca0644dc2b5577af154c973ca
Autor:
David Inman
Publikováno v:
Patterns, Vol 1, Iss 1, Pp 100011- (2020)
Alan Turing and Bletchley Park are rightly recognized for their work on breaking the Enigma code. However, this was built on a foundation of work during the 1930s by the Polish cryptographer, Marian Rejewski. Often working alone, and with limited res
Externí odkaz:
https://doaj.org/article/d58fb63fc4634e938bfada90c1e1d01d
Autor:
Adrienne E. Shapiro, Elias Sarkis, Jude Acloque, Almena Free, Yaneicy Gonzalez-Rojas, Rubaba Hussain, Erick Juarez, Jaynier Moya, Naval Parikh, David Inman, Deborah Cebrik, Ahmed Nader, Nadia Noormohamed, Qianwen Wang, Andrew Skingsley, Daren Austin, Amanda Peppercorn, Maria L. Agostini, Sergio Parra, Sophia Chow, Erik Mogalian, Phillip S. Pang, David K. Hong, Jennifer E. Sager, Wendy W. Yeh, Elizabeth L. Alexander, Leah A. Gaffney, Anita Kohli
BackgroundConvenient administration of coronavirus disease 2019 (COVID-19) treatment in community settings is desirable. Sotrovimab is a pan-sarbecovirus dual-action monoclonal antibody formulated for intravenous (IV) or intramuscular (IM) administra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eb08d2911a70bce8dc0f30cdc3cae2d
https://doi.org/10.1101/2023.03.21.23287410
https://doi.org/10.1101/2023.03.21.23287410
Autor:
Julia Smith, Alexandra R. Roberts, Charles Peterfy, Paul P. Tak, Philip G. Conaghan, Nina Mitchell, Robert L. Janiczek, Mario Berkowitz, Didier Saurigny, Elena Fisheleva, Katherine Davy, David Inman, Mark C. Genovese, Jatin Patel, Russell Williamson, Anubha Gupta, Mark Layton
Publikováno v:
The Lancet Rheumatology. 2:e666-e676
Summary Background Otilimab is a human monoclonal antibody that inhibits granulocyte–macrophage colony-stimulating factor (GM-CSF), a driver in many immune-mediated inflammatory conditions. We evaluated the effect of otilimab on the GM-CSF–chemok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73517d8a1f8e00ad232f83a81b7ba727
https://doi.org/10.1016/s2665-9913(20)30224-1
https://doi.org/10.1016/s2665-9913(20)30224-1
Autor:
Adrienne E. Shapiro, Elias Sarkis, Jude Acloque, Almena Free, Yaneicy Gonazalez-Rojas, Rubaba Hussain, Erick Juarez, Jaynier Moya, Naval Parikh, David Inman, Deborah Cebrik, Ahmed Nadeer, Nadia Noormohamed, Qianwen Wang, Andrew Skingsley, Daren Austin, Amanda Peppercorn, Sergio Parra, Sophia Chow, Erik Mogalian, Phillip S. Pang, David K. Hong, Jennifer E. Sager, Wendy W. Yeh, Elizabeth Alexander, Leah A. Gaffney, Anita Kohli
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3752de56eceb4b7a72aa696a1c003010
https://doi.org/10.2139/ssrn.4111060
https://doi.org/10.2139/ssrn.4111060
Autor:
Ruth M Barnard, David Inman, Kevin R. Page, Bart Keymeulen, Quentin Leirens, Alexander MacDonald, Antonella Napolitano, Kim Brown, David Lanham, Jonathan Bullman, Minesh Patel, André van Maurik, Enrica Mezzalana, Caroline O. S. Savage, Georgios Vlasakakis, Stefano Zamuner
Publikováno v:
British Journal of Clinical Pharmacology. 85:704-714
Aims This paper describes the pharmacological findings from a study where otelixizumab, an anti-CD3ɛ mAb, was dosed in new onset Type 1 diabetes mellitus (NOT1DM) patients. This is the first time that the full dose-response of an anti-CD3ɛ mAb has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3cc8aff306a4ae44c500abe35002d5
https://doi.org/10.1111/bcp.13842
https://doi.org/10.1111/bcp.13842
Autor:
Jesus A Simón-Campos, Christopher D. Buckley, Didier Saurigny, Elena Fisheleva, Anubha Gupta, Mark Layton, Jatin Patel, Carol Hawkes, Paul P. Tak, Russell Williamson, David Inman, Katherine Davy, Brandon D. Becker, Nina Mitchell, Vyacheslav Zhdan
Background The human monoclonal antibody otilimab inhibits granulocyte-macrophage colony-stimulating factor (GM-CSF), a key driver in immune-mediated inflammatory conditions. We aimed to evaluate the efficacy, safety, and key patient-reported outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ae4e653671eae7669ab3ba14c9131b
https://ora.ox.ac.uk/objects/uuid:5d0481f9-fb31-4f3d-b5f6-14b97e04e42e
https://ora.ox.ac.uk/objects/uuid:5d0481f9-fb31-4f3d-b5f6-14b97e04e42e
Autor:
Didier Saurigny, Deven Chauhan, Russell Williamson, Carol Hawkes, Brandon D. Becker, Paul P. Tak, David Inman, Katherine Davy, Christopher D. Buckley, Jesus Simon Campos, Jatin Patel, Mark Layton, Nina Mitchell, Vyacheslav Zhdan
Publikováno v:
Oral Presentations.
Background GSK3196165 is a human mAb that inhibits GM-CSF, a key driver in a broad range of immune-mediated conditions (Hamilton, 2016). In trials of patients with RA, inhibition of GM-CSF signaling has resulted in clinical benefit. GM-CSF is not onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d8644ff200ee1dc001dd26e699433c5
https://doi.org/10.1136/annrheumdis-2019-eular.6035
https://doi.org/10.1136/annrheumdis-2019-eular.6035
Autor:
Gina-Anne Levow, Patrick Littell, David Inman, Michael Tjalve, Joshua Crowgey, Jeff Good, Shobhana Lakshmi Chelliah, Sharon Hargus, Dan Garrette, Fei Xia, Emily M. Bender, Michael Maxwell, Kristen Howell
Publikováno v:
Proceedings of the 2nd Workshop on the Use of Computational Methods in the Study of Endangered Languages.
This paper describes the use of Shared Task Evaluation Campaigns by designing tasks that are compelling to speech and natural language processing researchers while addressing technical challenges in language documentation and exploiting growing archi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c82789901d09b4ad75a3bbc92b92b04b
https://doi.org/10.18653/v1/w17-0106
https://doi.org/10.18653/v1/w17-0106
Autor:
Dusana Cierna, Franco Roman, Rafael Arriaza, Merce Barrientos, Miguel Saavedra, David Inman, Benjamin Abarca, Patricia Regueiro
Publikováno v:
British journal of sports medicine. 51(4)
Background Although it is well known that injuries occur in combat sports, the true incidence of concussions is not clearly defined in the literature for karate competition. Aim To determine the incidence of concussions in top-level (World Karate Fed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47a2e28eadf93ed93cdc48a85167905
https://pubmed.ncbi.nlm.nih.gov/27986764
https://pubmed.ncbi.nlm.nih.gov/27986764