Zobrazeno 1 - 10
of 88
pro vyhledávání: '"David I. Kasahara"'
Autor:
Ronald Allan M. Panganiban, Zhiping Yang, Maoyun Sun, Chan Young Park, David I. Kasahara, Niccole Schaible, Ramaswamy Krishnan, Alvin T. Kho, Elliot Israel, Marc B. Hershenson, Scott T. Weiss, Blanca E. Himes, Jeffrey J. Fredberg, Kelan G. Tantisira, Stephanie A. Shore, Quan Lu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
The underlying mechanisms of how obesity increases asthma prevalence and severity are not well understood. Here, the authors show that antagonizing cholecystokinin and its receptor, CCKAR, in the lung attenuates obesity-associated airway hyperrespons
Externí odkaz:
https://doaj.org/article/627590137e8e4854b2f7c749238e36dd
Autor:
David I. Kasahara, Stephanie A. Shore
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesity-related changes
Externí odkaz:
https://doaj.org/article/dc710f720db24b3b9a50535b45611a3f
Autor:
David I. Kasahara, Jeremy E. Wilkinson, Youngji Cho, Aline P. Cardoso, Curtis Huttenhower, Stephanie A. Shore
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Interleukin-33 is released in the airways following acute ozone exposure and has the ability to cause airway hyperresponsiveness, a defining feature of asthma. Ozone causes greater airway hyperresponsiveness in male than female mi
Externí odkaz:
https://doaj.org/article/2a5596e459e14d008e9847c4cb8ad100
Autor:
Ross S. Osgood, Hiroki Tashiro, David I. Kasahara, Vladimir Yeliseyev, Lynn Bry, Stephanie A. Shore
Publikováno v:
Physiological Reports, Vol 8, Iss 19, Pp n/a-n/a (2020)
Abstract In mice, both androgens and the gut microbiota modify pulmonary responses to ozone. We hypothesized that androgens affect gut microbiota and thereby impact pulmonary responses to ozone. To address this hypothesis, we transferred cecal microb
Externí odkaz:
https://doaj.org/article/a497e44ca07b4fadafddc231c4f39750
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Early life changes in the microbiome contribute to the development of allergic asthma, but little is known about the importance of the microbiome for other forms of asthma. Ozone is a nonatopic asthma trigger that causes airway hyperresponsi
Externí odkaz:
https://doaj.org/article/b3408233d56e42ca862d213b8946721b
Publikováno v:
Physiological Reports, Vol 7, Iss 18, Pp n/a-n/a (2019)
Abstract Ozone causes airway hyperresponsiveness, a defining feature of asthma, and is an asthma trigger. In mice, ozone‐induced airway hyperresponsiveness is greater in males than in females, suggesting a role for sex hormones in the response to o
Externí odkaz:
https://doaj.org/article/d653add2482c482d9fc4888839f2929f
Autor:
David I. Kasahara, Youngji Cho, Vladimir Yeliseyev, Stephanie A. Shore, Curtis Huttenhower, Lynn Bry, Galeb Abu-Ali, Hiroki Tashiro, Jeffrey D. Brand
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 61:702-712
Obesity is a risk factor for asthma, especially nonatopic asthma, and attenuates the efficacy of standard asthma therapeutics. Obesity also augments pulmonary responses to ozone, a nonatopic asthma trigger. The purpose of this study was to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51cf897e5bc3e48f2f08ca8f6e81c47b
https://doi.org/10.1165/rcmb.2019-0144oc
https://doi.org/10.1165/rcmb.2019-0144oc
Autor:
Jeffrey J. Fredberg, Blanca E. Himes, Ronald Pangniban, Alvin Koh, Maoyun Sun, Elliot Israel, Quan Lu, David I. Kasahara, Marc Hershenson, Stephanie A. Shore, Scott T. Weiss, Kelan G. Tantisira, Chan Young Park
Obesity is a significant co-morbidity that associates with increased prevalence and severity of asthma. The mechanism underlying the obesity-asthma association remains poorly understood, and for obese asthmatics there is no effective therapy for obes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::147fd35e0ccaf9dbb931359fe9ed572a
https://doi.org/10.21203/rs.3.rs-841619/v1
https://doi.org/10.21203/rs.3.rs-841619/v1
Autor:
Ronald Allan M, Panganiban, Zhiping, Yang, Maoyun, Sun, Chan Young, Park, David I, Kasahara, Niccole, Schaible, Ramaswamy, Krishnan, Alvin T, Kho, Elliot, Israel, Marc B, Hershenson, Scott T, Weiss, Blanca E, Himes, Jeffrey J, Fredberg, Kelan G, Tantisira, Stephanie A, Shore, Quan, Lu
Publikováno v:
Nature communications. 14(1)
Obesity increases asthma prevalence and severity. However, the underlying mechanisms are poorly understood, and consequently, therapeutic options for asthma patients with obesity remain limited. Here we report that cholecystokinin-a metabolic hormone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::716f984ceea845e45c2a23e6bec029a6
https://pubmed.ncbi.nlm.nih.gov/36599824
https://pubmed.ncbi.nlm.nih.gov/36599824
Autor:
Hiroki Tashiro, Traci A. Brown, Galeb Abu-Ali, Ross S. Osgood, Youngji Cho, David I. Kasahara, Curtis Huttenhower, Stephanie A. Shore
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 60:198-208
We have previously reported that the mouse gut microbiome contributes to pulmonary responses to ozone, a common asthma trigger, and that short-chain fatty acids, end products of bacterial fermentation, likely contribute to this role of the microbiome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef7f59313300a373931e9d38ac7d3a4
https://doi.org/10.1165/rcmb.2018-0099oc
https://doi.org/10.1165/rcmb.2018-0099oc