Zobrazeno 1 - 10
of 48
pro vyhledávání: '"David I. Israel"'
Autor:
Jason Deng, Svetlana Belyanskaya, Ninad Prabhu, Christopher Arico-Muendel, Hongfeng Deng, Christopher B. Phelps, David I. Israel, Hongfang Yang, Joseph Boyer, G. Joseph Franklin, Jeremy L. Yap, Kenneth E. Lind, Ching-Hsuan Tsai, Christine Donahue, Jennifer D. Summerfield
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100171- (2024)
DNA-encoded small molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, it has been used to identify ligands against targets that are soluble or overexpressed on cell surfaces. Here,
Externí odkaz:
https://doaj.org/article/200cb0758edc446ea0423cf022c88bf1
Autor:
Qiuxia Chen, Chuan Liu, Wei Wang, Xiaoyun Meng, Xuemin Cheng, Xianyang Li, Longying Cai, Linfu Luo, Xu He, Huan Qu, Jing Luo, Hong Wei, Sen Gao, Guansai Liu, Jinqiao Wan, David I. Israel, Jin Li, Dengfeng Dou
Publikováno v:
ACS Chemical Biology. 18:25-33
The proteolysis targeting chimera (PROTAC) strategy results in the down-regulation of unwanted protein(s) for disease treatment. In the PROTAC process, a heterobifunctional degrader forms a ternary complex with a target protein of interest (POI) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8c796851f56d9442966a69a2d72203
https://doi.org/10.1021/acschembio.2c00797
https://doi.org/10.1021/acschembio.2c00797
Autor:
David I, Israel
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2541
DEL selections are designed to discover novel small molecule compounds attached to DNA that bind to a target protein. A known small molecule or peptide ligand that binds to the target protein can be conjugated to DNA to mimic compounds contained in D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9877e58677c002348a2d588f62953ef1
https://pubmed.ncbi.nlm.nih.gov/36083551
https://pubmed.ncbi.nlm.nih.gov/36083551
Autor:
Qiuxia, Chen, David I, Israel
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2541
DNA-encoded library (DEL) technology utilizes affinity-based selection methods to screen chemical libraries. DEL technology possesses some unique features compared to other small molecule screening technologies, such as the use of DNA identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd38b3de5408f386b88573fb2ecbb9b9
https://pubmed.ncbi.nlm.nih.gov/36083553
https://pubmed.ncbi.nlm.nih.gov/36083553
Autor:
Jennifer Ariazi, Andrew Benowitz, Vern De Biasi, Monique L. Den Boer, Stephanie Cherqui, Haifeng Cui, Nathalie Douillet, Eliseo A. Eugenin, David Favre, Spencer Goodman, Karine Gousset, Dorit Hanein, David I. Israel, Shunsuke Kimura, Robert B. Kirkpatrick, Nastaran Kuhn, Claire Jeong, Emil Lou, Robbie Mailliard, Stephen Maio, George Okafo, Matthias Osswald, Jennifer Pasquier, Roel Polak, Gabriele Pradel, Bob de Rooij, Peter Schaeffer, Vytenis A. Skeberdis, Ian F. Smith, Ahmad Tanveer, Niels Volkmann, Zhenhua Wu, Chiara Zurzolo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and
Externí odkaz:
https://doaj.org/article/b2e205f432ef419f9ebd1c6bb3338615
Publikováno v:
Biochemical and Biophysical Research Communications. 533:249-255
DEL selections are binding assays conducted with mixtures of chemically diverse DNA-tagged ligands and a screening target. DEL selections use DNA sequence counts to measure target binding, where ideally higher affinity ligands will have higher counts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07270831e011ceb293b086bffc365b07
https://doi.org/10.1016/j.bbrc.2020.04.029
https://doi.org/10.1016/j.bbrc.2020.04.029
Autor:
Qiuxia Chen, David I. Israel
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f4317e31831c8fefd6c7a239e4dd90
https://doi.org/10.1007/978-1-0716-2545-3_18
https://doi.org/10.1007/978-1-0716-2545-3_18
Autor:
Paolo A. Centrella, Peng Li, G Joseph Franklin, Svetlana L. Belyanskaya, Joseph P. Marino, Steven R. Skinner, Barry A. Morgan, Matthew A. Clark, Jason W. Dodson, Jeffrey A. Messer, Yun Ding, Jennifer L. DeLorey, David I. Israel
Publikováno v:
Bioorganicmedicinal chemistry. 41
Inhibition of soluble epoxide hydrolase (sEH) has recently emerged as a new approach to treat cardiovascular disease and respiratory disease. Inhibitors based on 1,3,5-triazine chemotype were discovered through affinity selection against two triazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ef26aa0ff6dd53c73f4758004748fd
https://pubmed.ncbi.nlm.nih.gov/34023664
https://pubmed.ncbi.nlm.nih.gov/34023664
Autor:
Qiuxia Chen, Kristin K. Ford, Jing Fan, David I. Israel, Timothy L. Foley, Jinqiao Wan, Ping Xie, Justin Hall, Xu Yanshan
Publikováno v:
Biochemical and biophysical research communications. 527(1)
DNA-encoded libraries (DELs) can contain billions of unique chemical species; selecting against such large inputs, it is typical to find more candidate binders than is reasonable to pursue for follow-up synthesis and testing. Given this wealth of cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3290029d28591dfa3156ea71835c7ce7
https://pubmed.ncbi.nlm.nih.gov/32446376
https://pubmed.ncbi.nlm.nih.gov/32446376
Publikováno v:
ChemBioChem. 18:837-842
DNA-encoded chemical library technology was developed with the vision of its becoming a transformational platform for drug discovery. The hope was that a new paradigm for the discovery of low-molecular-weight drugs would be enabled by combining the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e680dcf9fec4bfb23a79d7c55a5b8f1c
https://doi.org/10.1002/cbic.201700014
https://doi.org/10.1002/cbic.201700014