Zobrazeno 1 - 10
of 117
pro vyhledávání: '"David I. Cook"'
Autor:
Merav Mor, Ofer Beharier, David I Cook, Craig R Campbell, Levi A Gheber, Amos Katz, Arie Moran, Yoram Etzion
Publikováno v:
Metallomics.
ZnT1 is a major zinc transporter that regulates cellular zinc homeostasis. We have previously shown that ZnT1 have additional functions which are independent of its activity as a Zn2+ extruder. These include inhibition of the L type calcium channel (
Autor:
Nawiya Huipao, Suparerk Borwornpinyo, Suwimon Wiboon-Ut, Craig R Campbell, Il-Ha Lee, Siriphun Hiranyachattada, Chonlaphat Sukasem, Arunee Thitithanyanont, Chumpol Pholpramool, David I Cook, Anuwat Dinudom
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176974 (2017)
One of the key pathophysiologies of H5N1 infection is excessive proinflammatory cytokine response (cytokine storm) characterized by increases in IFN-β, TNF-α, IL-6, CXCL10, CCL4, CCL2 and CCL5 in the respiratory tract. H5N1-induced cytokine release
Externí odkaz:
https://doaj.org/article/2cf64e551fff416f9dbf798c7ba8f7ef
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0116938 (2015)
The present study investigates the role of small G-proteins of the Ras family in the epidermal growth factor (EGF)-activated cellular signalling pathway that downregulates activity of the epithelial Na+ channel (ENaC). We found that H-Ras is a key co
Externí odkaz:
https://doaj.org/article/824e5a27f4dc470b96d8cbe642e442df
Autor:
Yan Y Lam, Connie W Y Ha, Craig R Campbell, Andrew J Mitchell, Anuwat Dinudom, Jan Oscarsson, David I Cook, Nicholas H Hunt, Ian D Caterson, Andrew J Holmes, Len H Storlien
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34233 (2012)
We investigated the relationship between gut health, visceral fat dysfunction and metabolic disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet (HFD). Circulating glucose, insulin and inflammatory markers were
Externí odkaz:
https://doaj.org/article/8c333106d12c4d17a25295708bef0505
Autor:
Jenny M.A. Hoffmann, Andrew J. Holmes, Jan Oscarsson, Thomas J. Mather, Len H. Storlien, Ian D. Caterson, Nicholas H. Hunt, Anuwat Dinudom, Connie W. Y. Ha, Yan Y. Lam, David I. Cook
Publikováno v:
Obesity. 23:1429-1439
Objective To distinguish the effects of dietary fat profile on gut parameters and their relationships with metabolic changes and to determine the capacity of n-3 fatty acids to modify gut variables in the context of diet-induced metabolic dysfunction
Zinc transport and the inhibition of the L-type calcium channel are two separable functions of ZnT-1
Autor:
Asher Peretz, Ofer Beharier, Yoram Etzion, Daniel Gitler, Arie Moran, Raz Zarivach, Amos Katz, Il-Ha Lee, Craig Campbell, Shiri Levy, Eden Shusterman, David I. Cook, Anuwat Dinudom
Publikováno v:
Metallomics : integrated biometal science. 9(3)
Traditionally, proteins are considered to perform a single role, be it as an enzyme, a channel, a transporter or as a structural scaffold. However, recent studies have described moonlighting proteins that perform distinct and independent functions; f
Publikováno v:
REPRODUCTION. 145:73-84
Plasma membrane chloride channels (ClCs) play important roles in a broad range of cellular processes including cell volume regulation, proliferation, and transepithelial transport, all of which are critical during preimplantation embryonic developmen
Autor:
Helen J. Ball, David I. Cook, Georges E. Grau, Leia Hee, Nicholas H. Hunt, Andrew J. Mitchell, Anuwat Dinudom
Publikováno v:
International Journal for Parasitology
Graphical abstract
Lung complications during malaria infection can range from coughs and impairments in gas transfer to the development of acute respiratory distress syndrome (ARDS). Infecting C57BL/6 mice with Plasmodium berghei K173 strain (Pb
Lung complications during malaria infection can range from coughs and impairments in gas transfer to the development of acute respiratory distress syndrome (ARDS). Infecting C57BL/6 mice with Plasmodium berghei K173 strain (Pb
Autor:
Samantha Young, Richard Speare, Wyatt F. Voyles, Craig Campbell, Rebecca J. Webb, Ross A. Alford, David I. Cook, Jamie Voyles, Lee Berger, Lee F. Skerratt, Anuwat Dinudom
Publikováno v:
Science. 326:582-585
Croaking Frogs The global amphibian decline has been attributed, among other causes, to an amphibian skin disease chytridiomycosis caused by the fungus Batrachochytrium dendrobatidis . However, how this pathogen causes mortality has been unclear. Voy
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 35:235-241
1. The epithelial sodium channel (ENaC) is tightly regulated by hormonal and humoral factors, including cytosolic ion concentration and glucocorticoid and mineralocorticoid hormones. Many of these regulators of ENaC control its activity by regulating