Zobrazeno 1 - 10
of 75
pro vyhledávání: '"David I. C. Scopes"'
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2569-2576
7,8-Dichloro-1,2,3,4,5,6-hexahydrobenzo[ f ]quinolin-3-one 10 (R = H) is obtained by reaction of 5,6-dichloro-3,4-dihydronaphthalen-2(1H)-one pyrrolidine enamine 9 with acrylamide and is N-alkylated to 7,8-dichloro-1,2,3,4,5,6-hexahydro-4-propylbenzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03565b0eab2effdcb1e6ea3e7eeb6056
https://doi.org/10.1039/a702212c
https://doi.org/10.1039/a702212c
Autor:
David I. C. Scopes, Celestine T. O'Shaughnessy, J.C. Barnes, John W. Clitherow, Gavin J. Kilpatrick, Paul Beswick, J.D. Brown
Publikováno v:
European Journal of Pharmacology. 311:305-310
We have examined the specific binding of the tritiated derivative of the potent histamine H 3 receptor antagonist, [3,4- 3 H 2 ]-cyclohexyl-{[4-(3 H -imidazol-4-yl)-piperidin-1-yl]iminomethyl}-amine ([ 3 H]GR168320), to homogenates of rat cerebral co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b7fe781b1720e99383241d44f480f5
https://doi.org/10.1016/0014-2999(96)00428-1
https://doi.org/10.1016/0014-2999(96)00428-1
Autor:
David I. C. Scopes, J. W. Clitherow, P. Beswick, J. Clapham, D. J. Evans, J.C. Barnes, W. J. Irving, A. G. Hayes, J.D. Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:833-838
Replacement of the isothiourea moiety of known histamine H 3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::021a6f8820b7e6c9fe2cccf06616ac41
https://doi.org/10.1016/0960-894x(96)00122-9
https://doi.org/10.1016/0960-894x(96)00122-9
Publikováno v:
Synlett. 2004:2776-2778
A β-lactam template has been used to induce the stereochemistry in a simple route to imino sugars.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d68d74cee464e7b7f8aff9085f7b5756
https://doi.org/10.1055/s-2004-836021
https://doi.org/10.1055/s-2004-836021
Autor:
Elizabeth A. Graham, M. P. Turpin, David I. C. Scopes, Izaak Den Daas, Lee A. Harrison, David R. Bull, A. G. Hayes, Gavin J. Kilpatrick, Michael J. Sheehan, C. Large, M. R. Johnson, P. John Murray, Graeme Michael Robertson, Carole M. Stubbs
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:219-222
A novel series of arylpiperazines has been synthesised which show high affinity for dopamine D 3 receptors. Several of these compounds exhibit ca . 100 fold selectivity for the dopamine D 3 receptor over D 1 , D 2 and D 4 receptors. In vivo studies s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c78277447767e6bfc65e3323014d6d8b
https://doi.org/10.1016/0960-894x(95)00011-h
https://doi.org/10.1016/0960-894x(95)00011-h
Autor:
M. C. Carter, Eric W. Collington, Feniuk W, M. Skingle, J. W. Clitherow, C. C. Jordan, Connor He, I. B. Campbell, Guy A. Higgins, David I. C. Scopes
Publikováno v:
Journal of Medicinal Chemistry. 37:2253-2257
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa209fa6177615bf4104b943fcb365c
https://doi.org/10.1021/jm00041a001
https://doi.org/10.1021/jm00041a001
Publikováno v:
Journal of Medicinal Chemistry. 37:2138-2144
The synthesis of 5-(arylacetyl)-4-[(alkylamino)methyl]furo[3,2-c]pyri- dines (16-23, 26, 27) and their activities as κ-opioid receptor agonists are described. κ-Agonist potency was particularly sensitive to the na- ture of the basic moiety. In part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8f87bafa8530eb4e7932d2d67bf3de
https://doi.org/10.1021/jm00040a004
https://doi.org/10.1021/jm00040a004
Autor:
David I. C. Scopes
Publikováno v:
Expert Opinion on Investigational Drugs. 3:369-377
This article provides an overview of the development of selective K-opioid receptor antagonists as potential analgesics and neuroprotective agents. An important milestone in defining the properties of a K-receptor agonist was the discovery of the N-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c55e1c36fb0455c679dc8e08cff9c0
https://doi.org/10.1517/13543784.3.4.369
https://doi.org/10.1517/13543784.3.4.369
Autor:
Eugene, O'Hare, David I C, Scopes, J Mark, Treherne, John, Monaghan, Philip M, Palmer, Hozefa, Amijee, Eun-Mee, Kim
Publikováno v:
Journal of Alzheimer's disease : JAD. 25(2)
Behavioral effects of a novel anti-inflammatory SEN1176 were investigated. This pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine suppresses amyloid-β (Aβ)1-42-induced macrophage production of nitric oxide, TNF-α, IL-1β, and IL-6 in a dose-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4c58d4402cbf0e712cf33bdec3fafcb
https://pubmed.ncbi.nlm.nih.gov/21654060
https://pubmed.ncbi.nlm.nih.gov/21654060
Autor:
G.M. Drew, A. Travers, B.C. Ross, T.A. Panchal, E. Palmer, Steve P. Watson, A. Hilditch, David Middlemiss, J.G. Montana, M.J. Robertson, A.A.E. Hunt, G.R.M. Manchee, G.C. Hirst, J.M.S. Paton, T. Hubbard, David I. C. Scopes, G. Stuart, M.D. Dowle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2043-2046
A series of GR117289 derived amino acid-amide angiotensin II antagonists is described. The possibility that the amino acid-amide element of these molecules mimics the C-terminus of Angiotensin II is discounted. One of these compounds, (2g), exhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49036050cc030106b1f6c893bf2e68e
https://doi.org/10.1016/s0960-894x(01)81011-8
https://doi.org/10.1016/s0960-894x(01)81011-8