Zobrazeno 1 - 10
of 88
pro vyhledávání: '"David I Kasahara"'
Autor:
Joel A Mathews, David I Kasahara, Luiza Ribeiro, Allison P Wurmbrand, Fernanda M C Ninin, Stephanie A Shore
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131236 (2015)
We examined the role of γδ T cells in the induction of alternatively activated M2 macrophages and the resolution of inflammation after ozone exposure. Wildtype (WT) mice and mice deficient in γδ T cells (TCRδ-/- mice) were exposed to air or to o
Externí odkaz:
https://doaj.org/article/5c7e3faef98a46238b9eaa0ec677a6a7
Autor:
Joel A Mathews, Alison S Williams, Jeffrey D Brand, Allison P Wurmbrand, Lucas Chen, Fernanda Mc Ninin, Huiqing Si, David I Kasahara, Stephanie A Shore
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97707 (2014)
Ozone is an air pollutant that causes pulmonary symptoms. In mice, ozone exposure causes pulmonary injury and increases bronchoalveolar lavage macrophages and neutrophils. We have shown that IL-17A is important in the recruitment of neutrophils after
Externí odkaz:
https://doaj.org/article/012831df4c1b469a925ac43a62c47299
Autor:
David I Kasahara, Alison S Williams, Leandro A Benedito, Barbara Ranscht, Lester Kobzik, Christopher Hug, Stephanie A Shore
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65829 (2013)
Adiponectin, an adipose derived hormone with pleiotropic functions, binds to several proteins, including T-cadherin. We have previously reported that adiponectin deficient (Adipo(-/-)) mice have increased IL-17A-dependent neutrophil accumulation in t
Externí odkaz:
https://doaj.org/article/670afc39aa1445eeb8add390567d3314
Autor:
Alison S Williams, David I Kasahara, Norah G Verbout, Alexey V Fedulov, Ming Zhu, Huiqing Si, Allison P Wurmbrand, Christopher Hug, Barbara Ranscht, Stephanie A Shore
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41088 (2012)
Adiponectin is an adipose derived hormone that declines in obesity. We have previously shown that exogenous administration of adiponectin reduces allergic airways responses in mice. T-cadherin (T-cad; Cdh13) is a binding protein for the high molecula
Externí odkaz:
https://doaj.org/article/9f2430ecc1524d4bae9b339bbf49f753
Autor:
Ronald Allan M. Panganiban, Zhiping Yang, Maoyun Sun, Chan Young Park, David I. Kasahara, Niccole Schaible, Ramaswamy Krishnan, Alvin T. Kho, Elliot Israel, Marc B. Hershenson, Scott T. Weiss, Blanca E. Himes, Jeffrey J. Fredberg, Kelan G. Tantisira, Stephanie A. Shore, Quan Lu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
The underlying mechanisms of how obesity increases asthma prevalence and severity are not well understood. Here, the authors show that antagonizing cholecystokinin and its receptor, CCKAR, in the lung attenuates obesity-associated airway hyperrespons
Externí odkaz:
https://doaj.org/article/627590137e8e4854b2f7c749238e36dd
Autor:
Jeffrey J. Fredberg, Blanca E. Himes, Ronald Pangniban, Alvin Koh, Maoyun Sun, Elliot Israel, Quan Lu, David I. Kasahara, Marc Hershenson, Stephanie A. Shore, Scott T. Weiss, Kelan G. Tantisira, Chan Young Park
Obesity is a significant co-morbidity that associates with increased prevalence and severity of asthma. The mechanism underlying the obesity-asthma association remains poorly understood, and for obese asthmatics there is no effective therapy for obes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::147fd35e0ccaf9dbb931359fe9ed572a
https://doi.org/10.21203/rs.3.rs-841619/v1
https://doi.org/10.21203/rs.3.rs-841619/v1
Autor:
Ronald Allan M, Panganiban, Zhiping, Yang, Maoyun, Sun, Chan Young, Park, David I, Kasahara, Niccole, Schaible, Ramaswamy, Krishnan, Alvin T, Kho, Elliot, Israel, Marc B, Hershenson, Scott T, Weiss, Blanca E, Himes, Jeffrey J, Fredberg, Kelan G, Tantisira, Stephanie A, Shore, Quan, Lu
Publikováno v:
Nature communications. 14(1)
Obesity increases asthma prevalence and severity. However, the underlying mechanisms are poorly understood, and consequently, therapeutic options for asthma patients with obesity remain limited. Here we report that cholecystokinin-a metabolic hormone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::716f984ceea845e45c2a23e6bec029a6
https://pubmed.ncbi.nlm.nih.gov/36599824
https://pubmed.ncbi.nlm.nih.gov/36599824
Autor:
David I. Kasahara, Youngji Cho, Vladimir Yeliseyev, Stephanie A. Shore, Curtis Huttenhower, Lynn Bry, Galeb Abu-Ali, Hiroki Tashiro, Jeffrey D. Brand
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 61:702-712
Obesity is a risk factor for asthma, especially nonatopic asthma, and attenuates the efficacy of standard asthma therapeutics. Obesity also augments pulmonary responses to ozone, a nonatopic asthma trigger. The purpose of this study was to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51cf897e5bc3e48f2f08ca8f6e81c47b
https://doi.org/10.1165/rcmb.2019-0144oc
https://doi.org/10.1165/rcmb.2019-0144oc
Autor:
Hiroki Tashiro, Traci A. Brown, Galeb Abu-Ali, Ross S. Osgood, Youngji Cho, David I. Kasahara, Curtis Huttenhower, Stephanie A. Shore
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 60:198-208
We have previously reported that the mouse gut microbiome contributes to pulmonary responses to ozone, a common asthma trigger, and that short-chain fatty acids, end products of bacterial fermentation, likely contribute to this role of the microbiome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef7f59313300a373931e9d38ac7d3a4
https://doi.org/10.1165/rcmb.2018-0099oc
https://doi.org/10.1165/rcmb.2018-0099oc
Autor:
Hiroki Tashiro, Vladimir Yeliseyev, Stephanie A. Shore, David I. Kasahara, Ross S. Osgood, Lynn Bry
Publikováno v:
Physiological Reports
Physiological Reports, Vol 8, Iss 19, Pp n/a-n/a (2020)
Physiological Reports, Vol 8, Iss 19, Pp n/a-n/a (2020)
In mice, both androgens and the gut microbiota modify pulmonary responses to ozone. We hypothesized that androgens affect gut microbiota and thereby impact pulmonary responses to ozone. To address this hypothesis, we transferred cecal microbiota from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386e7a82e036daf3b670dbcecd52ac41
https://doi.org/10.14814/phy2.14584
https://doi.org/10.14814/phy2.14584