Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David I Hughes"'
Autor:
Kieran A Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C Dickie, Andrew H Cooper, Andrew M Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I Hughes, Gregory A Weir, John S Riddell, Andrew J Todd
Publikováno v:
eLife, Vol 12 (2023)
Somatosensory information is processed by a complex network of interneurons in the spinal dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y (NPY), either permanently or during development, suppress mechanical
Externí odkaz:
https://doaj.org/article/0aaa87dba12840cf9be5bf7916875d41
Autor:
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Publikováno v:
eLife, Vol 11 (2022)
Volatile small molecules, including the short-chain fatty acids (SCFAs), acetate and propionate, released by the gut microbiota from the catabolism of nondigestible starches, can act in a hormone-like fashion via specific G-protein-coupled receptors
Externí odkaz:
https://doaj.org/article/0b08f246bde34112a3c8bb4e1ef6d6fa
Autor:
Kelly M Smith, Tyler J Browne, Olivia C Davis, A Coyle, Kieran A Boyle, Masahiko Watanabe, Sally A Dickinson, Jacqueline A Iredale, Mark A Gradwell, Phillip Jobling, Robert J Callister, Christopher V Dayas, David I Hughes, Brett A Graham
Publikováno v:
eLife, Vol 8 (2019)
Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in sensory processing. The neuronal circuits in this region that underpin sensory perception must be clarified to better understand how dysfunction can lead to pa
Externí odkaz:
https://doaj.org/article/e0cd9725113d49e9aa0bf5e1f78d7155
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
In this perspective, we propose the absence of detailed information regarding spinal cord circuits that process sensory information remains a major barrier to advancing analgesia. We highlight recent advances showing that functionally discrete popula
Externí odkaz:
https://doaj.org/article/eab843e9807a486d91ad563f601bbef9
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78309 (2013)
Laminae I-III of the spinal dorsal horn contain many inhibitory interneurons that use GABA and/or glycine as a neurotransmitter. Distinct neurochemical populations can be recognised among these cells, and these populations are likely to have differin
Externí odkaz:
https://doaj.org/article/f6687ddd128c45cebcc029cff2b0bed4
Autor:
Kieran A. Boyle, Erika Polgár, Maria Gutierrez-Mecinas, Allen C. Dickie, Andrew H. Cooper, Andrew M. Bell, M. Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I. Hughes, Greg A. Weir, John S. Riddell, Andrew J. Todd
Somatosensory information is processed by a complex network of interneurons in the spinal dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y (NPY), either permanently or during development, suppress mechanical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c86db481d4bfefadd400747f0b891e8
https://doi.org/10.1101/2023.02.10.528013
https://doi.org/10.1101/2023.02.10.528013
Autor:
David I. Hughes, Andrew J. Todd
Publikováno v:
Neuromethods ISBN: 9781071620380
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7417e1103d0b48cd4e33e119ed628917
https://doi.org/10.1007/978-1-0716-2039-7_11
https://doi.org/10.1007/978-1-0716-2039-7_11
Autor:
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde3445f5c9a1248e900c175a0342674
https://doi.org/10.7554/elife.73777.sa2
https://doi.org/10.7554/elife.73777.sa2
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 11 (2020)
Frontiers in Physiology, Vol 11 (2020)
The pain experience depends on the relay of nociceptive signals from the spinal cord dorsal horn to higher brain centers. This function is ultimately achieved by the output of a small population of highly specialized neurons called projection neurons
Autor:
Jessica F. Madden, Olivia C. Davis, Kieran A. Boyle, Jacqueline A. Iredale, Tyler J. Browne, Robert J. Callister, Douglas W. Smith, Phillip Jobling, David I. Hughes, Brett A. Graham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
Neurons located in dorsal root ganglia (DRG) are crucial for transmitting peripheral sensations such as proprioception, touch, temperature, and nociception to the spinal cord before propagating these signals to higher brain structures. To date, diffi