Zobrazeno 1 - 10
of 67
pro vyhledávání: '"David I Hughes"'
Autor:
Tyler J. Browne, Kelly M. Smith, Mark A. Gradwell, Christopher V. Dayas, Robert J. Callister, David I. Hughes, Brett A. Graham
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Spinal projection neurons (PNs) are defined by long axons that travel from their origin in the spinal cord to the brain where they relay sensory information from the body. The existence and function of a substantial axon collateral network,
Externí odkaz:
https://doaj.org/article/ec93f78f34ca4384b30c43e37a0ef70a
Autor:
Olivia C. Davis, Allen C. Dickie, Marami B. Mustapa, Kieran A. Boyle, Tyler J. Browne, Mark A. Gradwell, Kelly M. Smith, Erika Polgár, Andrew M. Bell, Éva Kókai, Masahiko Watanabe, Hendrik Wildner, Hanns Ulrich Zeilhofer, David D. Ginty, Robert J. Callister, Brett A. Graham, Andrew J. Todd, David I. Hughes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate presynaptic inhibition. However, until now the source of this axoaxonic synaptic input w
Externí odkaz:
https://doaj.org/article/e1e8b47c69cd415985186a348e491925
Autor:
Kieran A Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C Dickie, Andrew H Cooper, Andrew M Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I Hughes, Gregory A Weir, John S Riddell, Andrew J Todd
Publikováno v:
eLife, Vol 12 (2023)
Somatosensory information is processed by a complex network of interneurons in the spinal dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y (NPY), either permanently or during development, suppress mechanical
Externí odkaz:
https://doaj.org/article/0aaa87dba12840cf9be5bf7916875d41
Autor:
Mark A. Gradwell, Kelly M. Smith, Christopher V. Dayas, Douglas W. Smith, David I. Hughes, Robert J. Callister, Brett A. Graham
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
The incidence of pain symptoms such as allodynia are known to increase with age. Parvalbumin expressing interneurons (PVINs) within the dorsal horn (DH) of the spinal cord play an important role in allodynia whereby their inhibitory connections preve
Externí odkaz:
https://doaj.org/article/baec76e0ce484c0f82624bcd0055f3e3
Autor:
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Publikováno v:
eLife, Vol 11 (2022)
Volatile small molecules, including the short-chain fatty acids (SCFAs), acetate and propionate, released by the gut microbiota from the catabolism of nondigestible starches, can act in a hormone-like fashion via specific G-protein-coupled receptors
Externí odkaz:
https://doaj.org/article/0b08f246bde34112a3c8bb4e1ef6d6fa
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The pain experience depends on the relay of nociceptive signals from the spinal cord dorsal horn to higher brain centers. This function is ultimately achieved by the output of a small population of highly specialized neurons called projection neurons
Externí odkaz:
https://doaj.org/article/5f0fa275e7564d96b0f9b7499d0fea4f
Autor:
Jessica F. Madden, Olivia C. Davis, Kieran A. Boyle, Jacqueline A. Iredale, Tyler J. Browne, Robert J. Callister, Douglas W. Smith, Phillip Jobling, David I. Hughes, Brett A. Graham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Neurons located in dorsal root ganglia (DRG) are crucial for transmitting peripheral sensations such as proprioception, touch, temperature, and nociception to the spinal cord before propagating these signals to higher brain structures. To date, diffi
Externí odkaz:
https://doaj.org/article/bede2859bc2b436ba560bb1b689f3474
Autor:
Tyler J. Browne, Mark A. Gradwell, Jacqueline A. Iredale, Jessica F. Maden, Robert J. Callister, David I. Hughes, Christopher V. Dayas, Brett A. Graham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The superficial dorsal horn (SDH, LI-II) of the spinal cord receives and processes multimodal sensory information from skin, muscle, joints, and viscera then relay it to the brain. Neurons within the SDH fall into two broad categories, projection neu
Externí odkaz:
https://doaj.org/article/f7cbb58569d74ea7bf1a6fa6f2d258b2
Autor:
Cornelia Roesl, Elizabeth R. Evans, Kosala N. Dissanayake, Veronika Boczonadi, Ross A. Jones, Graeme R. Jordan, Leire Ledahawsky, Guy C. C. Allen, Molly Scott, Alanna Thomson, Thomas M. Wishart, David I. Hughes, Richard J. Mead, Clifford C. Shone, Clarke R. Slater, Thomas H. Gillingwater, Paul A. Skehel, Richard R. Ribchester
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1499 (2021)
Live imaging of neuromuscular junctions (NMJs) in situ has been constrained by the suitability of ligands for inert vital staining of motor nerve terminals. Here, we constructed several truncated derivatives of the tetanus toxin C-fragment (TetC) fus
Externí odkaz:
https://doaj.org/article/13eea35c1e66435fbc176e5c7bc2404b
Autor:
Kelly M Smith, Tyler J Browne, Olivia C Davis, A Coyle, Kieran A Boyle, Masahiko Watanabe, Sally A Dickinson, Jacqueline A Iredale, Mark A Gradwell, Phillip Jobling, Robert J Callister, Christopher V Dayas, David I Hughes, Brett A Graham
Publikováno v:
eLife, Vol 8 (2019)
Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in sensory processing. The neuronal circuits in this region that underpin sensory perception must be clarified to better understand how dysfunction can lead to pa
Externí odkaz:
https://doaj.org/article/e0cd9725113d49e9aa0bf5e1f78d7155