Zobrazeno 1 - 10
of 57
pro vyhledávání: '"David I Finkelstein"'
Autor:
Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer Gupta, Christine T O. Nguyen, David I Finkelstein, Yuyi You, Paul A Haynes, Ghasem H Salekdeh, Stuart L Graham, Mehdi Mirzaei
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 6, Pp 1262-1276 (2024)
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two pr
Externí odkaz:
https://doaj.org/article/f8fe9e44ce7e49208ce6a071ba24f39c
Autor:
Dominic J Hare, Bárbara Rita Cardoso, Erika P Raven, Kay L Double, David I Finkelstein, Ewa A Szymlek-Gay, Beverley-Ann Biggs
Publikováno v:
npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-5 (2017)
Abstract Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that ind
Externí odkaz:
https://doaj.org/article/f22c5328fdf74dc0b1ae3c8bb9fca3a3
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183683 (2017)
Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which there are currently no effective pharmacological treatment options. In this study then, we utilized a mouse model of TBI to assess the therapeutic potenti
Externí odkaz:
https://doaj.org/article/452bc126346e4fd4b7b63bbb9a8987c8
Autor:
Kun Zhou, Sepideh Motamed, George A Thouas, Claude C Bernard, Dan Li, Helena C Parkington, Harold A Coleman, David I Finkelstein, John S Forsythe
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151589 (2016)
Electroactive materials have been investigated as next-generation neuronal tissue engineering scaffolds to enhance neuronal regeneration and functional recovery after brain injury. Graphene, an emerging neuronal scaffold material with charge transfer
Externí odkaz:
https://doaj.org/article/81f81dc89cca47b4a9d5e08dfbc190fb
Autor:
Jason Howitt, Amanda M Gysbers, Scott Ayton, Francine Carew-Jones, Ulrich Putz, David I Finkelstein, Glenda M Halliday, Seong-Seng Tan
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87119 (2014)
Iron misregulation is a central component in the neuropathology of Parkinson's disease. The iron transport protein DMT1 is known to be increased in Parkinson's brains linking functional transport mechanisms with iron accumulation. The regulation of D
Externí odkaz:
https://doaj.org/article/767b3a60127b4941bb2af571c32d443e
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93307 (2014)
Friedreich ataxia (FRDA) is an autosomal recessive disorder characterized by neurodegeneration and cardiomyopathy. The presence of a GAA trinucleotide repeat expansion in the first intron of the FXN gene results in the inhibition of gene expression a
Externí odkaz:
https://doaj.org/article/8bb4f058c31b43c498cbc20e4eb6433a
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60378 (2013)
Expression of A53T mutant human alpha-synuclein under the mouse prion promoter is among the most successful transgenic models of Parkinson's disease. Accumulation of A53T alpha-synuclein causes adult mice to develop severe motor impairment resulting
Externí odkaz:
https://doaj.org/article/c8fe67e8daad4d37b90290514d940b1b
Autor:
Susann Cattepoel, Alexander Schaub, Miriam Ender, Annette Gaida, Alain Kropf, Ursula Guggisberg, Marc W Nolte, Louis Fabri, Paul A Adlard, David I Finkelstein, Reinhard Bolli, Sylvia M Miescher
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63162 (2013)
Intravenous Immunoglobulin (IVIG) has been proposed as a potential therapeutic for Alzheimer's disease (AD) and its efficacy is currently being tested in mild-to-moderate AD. Earlier studies reported the presence of anti-amyloid beta (Aβ) antibodies
Externí odkaz:
https://doaj.org/article/088171df589246178f0026ae2d98411a
Autor:
Paul A Adlard, Laura Bica, Anthony R White, Milawaty Nurjono, Gulay Filiz, Peter J Crouch, Paul S Donnelly, Roberto Cappai, David I Finkelstein, Ashley I Bush
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17669 (2011)
We have previously demonstrated that brief treatment of APP transgenic mice with metal ionophores (PBT2, Prana Biotechnology) rapidly and markedly improves learning and memory. To understand the potential mechanisms of action underlying this phenomen
Externí odkaz:
https://doaj.org/article/4e763946483f42a89c147264e6af3f94
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106296- (2023)
Multiple system atrophy (MSA) is a rare, progressive neurodegenerative disorder characterised by autonomic, pyramidal, parkinsonian and/or cerebellar dysfunction. Autonomic symptoms of MSA include deficits associated with the gastrointestinal (GI) sy
Externí odkaz:
https://doaj.org/article/87b7eb48c9f94275b93729d7713e7ff9