Zobrazeno 1 - 10
of 60
pro vyhledávání: '"David I, Bellovin"'
Autor:
Renumathy Dhanasekaran, Jangho Park, Alekesey Yevtodiyenko, David I. Bellovin, Stacey J. Adam, Anand Rajan KD, Meital Gabay, Hanan Fernando, Julia Arzeno, Vinodhini Arjunan, Sergei Gryanzov, Dean W. Felsher
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 850-859 (2020)
The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce r
Externí odkaz:
https://doaj.org/article/bc11f22a57154389bb3c27396566ada8
Autor:
Hong Xiang, Abigael G. Chan, Ago Ahene, David I. Bellovin, Rong Deng, Amy W. Hsu, Ursula Jeffry, Servando Palencia, Janine Powers, James Zanghi, Helen Collins
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Bemarituzumab (FPA144) is a first-in-class, humanized, afucosylated immunoglobulin G1 monoclonal antibody (mAb) directed against fibroblast growth factor receptor 2b (FGFR2b) with two mechanisms of action against FGFR2b-overexpressing tumors: inhibit
Externí odkaz:
https://doaj.org/article/631148f01f704dc69b35977cd33a11de
Autor:
Renumathy Dhanasekaran, Virginie Baylot, Minsoon Kim, Sibu Kuruvilla, David I Bellovin, Nia Adeniji, Anand Rajan KD, Ian Lai, Meital Gabay, Ling Tong, Maya Krishnan, Jangho Park, Theodore Hu, Mustafa A Barbhuiya, Andrew J Gentles, Kasthuri Kannan, Phuoc T Tran, Dean W Felsher
Publikováno v:
eLife, Vol 9 (2020)
Metastasis is a major cause of cancer mortality. We generated an autochthonous transgenic mouse model whereby conditional expression of MYC and Twist1 enables hepatocellular carcinoma (HCC) to metastasize in >90% of mice. MYC and Twist1 cooperate and
Externí odkaz:
https://doaj.org/article/70e4719673194a84a60d73e0f1a3b836
Autor:
Delaney K. Sullivan, Anja Deutzmann, Josiah Yarbrough, Maya S. Krishnan, Arvin M. Gouw, David I. Bellovin, Stacey J. Adam, Daniel F. Liefwalker, Renumathy Dhanasekaran, Dean W. Felsher
Publikováno v:
Oncogene. 41:4960-4970
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3eb64b45b6309a74b1576bf01221b33
https://doi.org/10.1038/s41388-022-02458-9
https://doi.org/10.1038/s41388-022-02458-9
Autor:
Dean W. Felsher, Sanjiv Sam Gambhir, Qiwei Yang, Julia Arzeno, Aleksey Yevtodiyenko, David I. Bellovin, Hua Fan-Minogue, Zhongwei Cao
Supplementary Figure Legends 1-10 from MYC Phosphorylation, Activation, and Tumorigenic Potential in Hepatocellular Carcinoma Are Regulated by HMG-CoA Reductase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b29df34d7de03e4fae914a1118c2c0d
https://doi.org/10.1158/0008-5472.22390767.v1
https://doi.org/10.1158/0008-5472.22390767.v1
Autor:
Dean W. Felsher, Sanjiv Sam Gambhir, Qiwei Yang, Julia Arzeno, Aleksey Yevtodiyenko, David I. Bellovin, Hua Fan-Minogue, Zhongwei Cao
Supplementary Figures 6-10 from MYC Phosphorylation, Activation, and Tumorigenic Potential in Hepatocellular Carcinoma Are Regulated by HMG-CoA Reductase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2b96f19cc0273ee54b149cfd420dd4
https://doi.org/10.1158/0008-5472.22390761.v1
https://doi.org/10.1158/0008-5472.22390761.v1
Autor:
Dean W. Felsher, Sanjiv Sam Gambhir, Qiwei Yang, Julia Arzeno, Aleksey Yevtodiyenko, David I. Bellovin, Hua Fan-Minogue, Zhongwei Cao
Supplementary Figures 1-5 from MYC Phosphorylation, Activation, and Tumorigenic Potential in Hepatocellular Carcinoma Are Regulated by HMG-CoA Reductase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6710e3d434227824229e72d07ffb88f5
https://doi.org/10.1158/0008-5472.22390764.v1
https://doi.org/10.1158/0008-5472.22390764.v1
Autor:
Dean W. Felsher, Sanjiv Sam Gambhir, Qiwei Yang, Julia Arzeno, Aleksey Yevtodiyenko, David I. Bellovin, Hua Fan-Minogue, Zhongwei Cao
MYC is a potential target for many cancers but is not amenable to existing pharmacologic approaches. Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) by statins has shown potential efficacy against a number of cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35d6ae0c5c391cd6e46b0a9b9d4cacb8
https://doi.org/10.1158/0008-5472.c.6503040.v1
https://doi.org/10.1158/0008-5472.c.6503040.v1
Autor:
Jing Zhang, Wenhua Shi, Min Chen, Xinchuan Dai, Hongshui Liu, Shou Li, Lina Wang, Bee-Chun Sun, Monica You, Vivian Morton, Qiuping Ye, Lishan Kang, Bing Wan, Peter Brams, David I. Bellovin
Publikováno v:
Cancer Research. 82:3590-3590
Despite the promise of immunotherapy for cancer treatment, nearly 80% of patients fail to respond to checkpoint inhibitor (CPI) therapy. Regulatory T cells (Tregs), which inhibit immune responses in the tumor microenvironment via multiple suppressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a765a1cb55f1e9c9fff451096351b7a8
https://doi.org/10.1158/1538-7445.am2022-3590
https://doi.org/10.1158/1538-7445.am2022-3590
Autor:
Shruti Lal, Bee-Chun Sun, Yuping Chen, Tom Huang, Neil Bhola, Vivian Morton, Kevin Chen, Shanghua Xia, Haoyu Zhang, Qiuping Ye, Petter Veiby, David I. Bellovin, Yuhua Ji
Publikováno v:
Cancer Research. 82:2594-2594
DNA-damaging poisons and replicative stress commonly result in increased double-strand breaks (DSBs) in tumor cells. Non-homologous end joining (NHEJ), driven by the enzymatic function of DNA-PK, is one of the critical pathways employed to repair suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27561bf2cf06cd4a45062876bbbd2398
https://doi.org/10.1158/1538-7445.am2022-2594
https://doi.org/10.1158/1538-7445.am2022-2594