Zobrazeno 1 - 10
of 74
pro vyhledávání: '"David Hum"'
Autor:
Fatima Al Ali, Laurent Abel, Jean-François Emile, Davood Mansouri, Mahbuba Rahman, Franck Rapaport, Stéphanie Boisson-Dupuis, Nicholas Hernandez, Taushif Khan, Anna-Lena Neehus, David Hum, Benedetta Bigio, Vivien Béziat, Nico Marr, Jean-Laurent Casanova, Scott Drutman, Jacinta Bustamante, Emmanuelle Jouanguy, Majid Marjani, Robert Fisch, Ruslana Bryk, Nahal Mansouri, Serkan Belkaya, Lazaro Lorenzo-Diaz, Carl Nathan, Seyed Alireza Mahdaviani
Publikováno v:
N Engl J Med
BACKGROUND: Cytomegalovirus (CMV) can cause severe disease in children and adults with a variety of inherited or acquired T-cell immunodeficiencies, who are prone to multiple infections. It can also rarely cause disease in otherwise healthy persons.
Autor:
Peng Zhang, Katharina Thoma, Bingnan Lyu, Gulbu Uzel, Juan Li, Boualem Hammadi, András N Spaan, Jamila El Baghdadi, Alexandra F. Freeman, Charlotte Cunningham-Rundles, Yu Zhang, Jean-Laurent Casanova, Claire Fieschi, Franck Rapaport, Jérémie Rosain, Vivien Béziat, Simon J. Pelham, Wei-Te Lei, Anne Puel, Maya Chrabieh, Helen C. Su, V. Koneti Rao, David Hum, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Mélanie Migaud, Anne-Sophie Korganow, Qian Zhang, Aurélie Cobat, Steven M. Holland, Laurent Abel, Vishukumar Aimanianda, Bertrand Boisson, Manfred Fliegauf, Benedetta Bigio, Bodo Grimbacher, Yoann Seeleuthner, Takaki Asano, Carol J Saunders, Shen-Ying Zhang, Emmanuelle Jouanguy
Publikováno v:
Journal of Experimental Medicine. 218
Autosomal dominant (AD) NFKB1 deficiency is thought to be the most common genetic etiology of common variable immunodeficiency (CVID). However, the causal link between NFKB1 variants and CVID has not been demonstrated experimentally and genetically,
Autor:
Capucine Picard, Joëlle Khourieh, Jane Peake, Antoine Guérin, Bertrand Boisson, Aziz Bousfiha, Jamila El Baghdadi, David Hum, Takaki Asano, Jean-Laurent Casanova, Andrew Williams, Simon J. Pelham, Stéphanie Boisson-Dupuis, Peng Zhang, Maya Chrabieh, Luke Droney, Wei-Te Lei, Ilham Fadil, Ji Eun Han, András N Spaan, Qian Zhang, Nevin Hatipoğlu, Franck Rapaport, Anne Puel, Tanwir Habib, Nico Marr, Fatih Celmeli, Vivien Béziat, Joseph Mackie, Biman Saikia, Stuart G. Tangye, Laurent Abel, Tayfun Ozcelik, Juan Li, Sudhir Gupta, Luckshman Ganeshanandan
Publikováno v:
The Journal of Experimental Medicine
Most patients with autosomal dominant hyper-IgE syndrome (AD-HIES) are heterozygous for rare STAT3 variants. The mechanism of dominance was recently questioned. The authors show that both in-frame and out-of-frame STAT3 variants underlie AD-HIES by n
Autor:
Yanqi Cao, Jinfeng Liang, Chunguo Wang, Xuejie Bao, Siqi Li, Qi Liu, Bin Zeng, David Humberto Lopez, Ruoxi Yu
Publikováno v:
Pharmaceutical Biology, Vol 61, Iss 1, Pp 973-985 (2023)
AbstractContext Qing Cuo Formula (QCF) is a traditional Chinese medicine for treating acne, but its active compounds and molecular mechanisms are unclear.Objective To investigate the material basis and molecular mechanism of QCF.Materials and methods
Externí odkaz:
https://doaj.org/article/7e0c8bf76ef14598a9b815ea468e6365
Autor:
Matthieu Bouaziz, Sirous Zeinali, Vignesh Gunasekharan, Fabienne Jabot-Hanin, Sarah Jill De Jong, Peter Itin, Nessa Aghazadeh, Xavier Rueda Cadena, E. Imahorn, Aurelia D’Amico, Amandine Crequer, Irina Matos, Elaine Fuchs, Bettina Burger, Janet Markle, David Hum, Etienne Patin, Florian Full, Bayaki Saka, Amir Hossein Saeidian, Laurent Abel, James G. Krueger, Nataly Portilla Maya, Claire Q.F. Wang, Jouni Uitto, Emmanuelle Jouanguy, Leila Youssefian, Hassan Vahidnezhad, Armin Ensser, Andrés Augusto Arias, Leslie V. Parise, Tina M. Leisner, Jean-Laurent Casanova, Lou Laimins, Lazaro Lorenzo, Gérard Orth, José Luis Franco
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2018, 215 (9), pp.2289-2310. ⟨10.1084/jem.20170308⟩
Journal of Experimental Medicine, 2018, 215 (9), pp.2289-2310. ⟨10.1084/jem.20170308⟩
Journal of Experimental Medicine, Rockefeller University Press, 2018, 215 (9), pp.2289-2310. ⟨10.1084/jem.20170308⟩
Journal of Experimental Medicine, 2018, 215 (9), pp.2289-2310. ⟨10.1084/jem.20170308⟩
International audience; Patients with epidermodysplasia verruciformis (EV) and biallelic null mutations of TMC6 (encoding EVER1) or TMC8 (EVER2) are selectively prone to disseminated skin lesions due to keratinocyte-tropic human β-papillomaviruses (
Autor:
Eduardo Hernandez-Samaniego, Carmen Navarro-Gomez, David Humberto Sánchez, Jesús Rubén Sánchez-Navarro
Publikováno v:
Water Practice and Technology, Vol 18, Iss 8, Pp 1991-2001 (2023)
Maintaining a constant flow in a potable water distribution hydraulic system is challenging due to fluctuations caused by changes in user demand and seasonal factors. This study aimed to calculate the coefficients and curves of hourly and daily varia
Externí odkaz:
https://doaj.org/article/735d02bc5c5149bfaf3025cd69ddfec1
Autor:
Scott B, Drutman, Filomeen, Haerynck, Franklin L, Zhong, David, Hum, Nicholas J, Hernandez, Serkan, Belkaya, Franck, Rapaport, Sarah Jill, de Jong, David, Creytens, Simon J, Tavernier, Katrien, Bonte, Sofie, De Schepper, Jutte, van der Werff Ten Bosch, Lazaro, Lorenzo-Diaz, Andy, Wullaert, Xavier, Bossuyt, Gérard, Orth, Vincent R, Bonagura, Vivien, Béziat, Laurent, Abel, Emmanuelle, Jouanguy, Bruno, Reversade, Jean-Laurent, Casanova
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(38)
Juvenile-onset recurrent respiratory papillomatosis (JRRP) is a rare and debilitating childhood disease that presents with recurrent growth of papillomas in the upper airway. Two common human papillomaviruses (HPVs), HPV-6 and -11, are implicated in
Autor:
Sarah Jill De Jong, Sofie De Schepper, Jean-Laurent Casanova, Jutte van der Werff ten Bosch, David Hum, Emmanuelle Jouanguy, Franklin L. Zhong, Vincent R. Bonagura, Scott Drutman, Nicholas Hernandez, David Creytens, Gérard Orth, Katrien Bonte, Andy Wullaert, Franck Rapaport, Filomeen Haerynck, Laurent Abel, Serkan Belkaya, Xavier Bossuyt, Vivien Béziat, Lazaro Lorenzo-Diaz, Bruno Reversade, Simon Tavernier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 116(38), 19055-19063. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Juvenile-onset recurrent respiratory papillomatosis (JRRP) is a rare and debilitating childhood disease that presents with recurrent growth of papillomas in the upper airway. Two common human papillomaviruses (HPVs), HPV-6 and -11, are implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccc719080bb3cc3a6a38e5db3e92583
https://pure.amc.nl/en/publications/homozygous-nlrp1-gainoffunction-mutation-in-siblings-with-a-syndromic-form-of-recurrent-respiratory-papillomatosis(16988276-9a9b-4487-b87c-baf543687e04).html
https://pure.amc.nl/en/publications/homozygous-nlrp1-gainoffunction-mutation-in-siblings-with-a-syndromic-form-of-recurrent-respiratory-papillomatosis(16988276-9a9b-4487-b87c-baf543687e04).html
Autor:
Alexander Emanuel Torres Romero, David Humberto Cárdenas Villacres, Raquel de los Angeles Salas Ibarra
Publikováno v:
Ingenio, Vol 7, Iss 1 (2024)
En la actualidad, la carrera de Ingeniería Eléctrica en la Universidad Politécnica Salesiana, sede Guayaquil campus Centenario, se enfrenta a limitaciones de recursos para enseñar el análisis de corriente alterna en Sistemas Eléctricos de Poten
Externí odkaz:
https://doaj.org/article/6e394712b19b4db2846de8f276f9ba36
Autor:
Gladys Valverde-Franco, Jean-Pierre Pelletier, David Hum, Johanne Martel-Pelletier, Bertrand Lussier, Hassan Fahmi, Koichi Matsuo, Mohit Kapoor
Publikováno v:
The American Journal of Pathology. 185:335-346
Osteoarthritis (OA) is characterized by progressive joint destruction, including synovial membrane alteration. EphB4 and its ligand ephrin-B2 were found in vitro to positively affect OA subchondral bone and cartilage. In vivo in an experimental mouse