Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David Howard Williams"'
Autor:
David Howard Williams, Nigel Alan Swain, Charlotte Alice Louise Lane, Michael Paradowski, Duncan Hay, Matthew D. Selby, Charles E. Mowbray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1156-1159
This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94d2bdbb82b128d16e17b7182c7d376
https://doi.org/10.1016/j.bmcl.2011.11.098
https://doi.org/10.1016/j.bmcl.2011.11.098
Autor:
Rawal Jaiessh, Amy Randall, Tram T. Tran, Fiona M. Adam, Daniel Siddle, Iain Gardner, Tanya Parkinson, Manos Perros, David R. Fenwick, Christopher Pickford, Juin Fok-Seang, Charles E. Mowbray, David Howard Williams, Donald Stuart Middleton, Hannah Vuong, Peter T. Stephenson, Michelle Y. Platts, Duncan Hay
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5246-5249
A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28. The rat pharmacokinetic and antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3a4d25958155d25e9e2f74217f4f79
https://doi.org/10.1016/j.bmcl.2009.06.080
https://doi.org/10.1016/j.bmcl.2009.06.080
Autor:
Gill Allan, Amy Randall, Sandra D. Newman, Romuald Corbau, Charles E. Mowbray, David Howard Williams, Manos Perros, Mike Westby, Duncan Hay, Donald Stuart Middleton, Hannah Vuong, Lyn H. Jones, Rob Webster
Publikováno v:
ChemMedChem. 3:1756-1762
A major problem associated with non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of HIV is their vulnerability to mutations in the allosteric binding site of reverse transcriptase that can result in the development of a resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d441ac28cd9f0ff20ac050167e4fa7a
https://doi.org/10.1002/cmdc.200800183
https://doi.org/10.1002/cmdc.200800183
Autor:
Emanuel Schenck, Wai L. Liu, Rhys M. Jones, Nick Clarke, Charlotte Alice Louise Lane, Michael Paradowski, Charles E. Mowbray, Michelle Collins, Mathew D. Selby, Andrew Simon Bell, David Howard Williams, Sandra D. Newman, Nigel Alan Swain
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
We describe the development of novel benzimidazoles as small molecule histamine H4 receptor (H4R) antagonists and their profiling in rat early toxicity studies. The discovery and optimisation of a second series of pyrimidine based antagonists is then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0118a0e5697a3b149b345b203e8c0d1
https://pubmed.ncbi.nlm.nih.gov/21920751
https://pubmed.ncbi.nlm.nih.gov/21920751
Autor:
Jaiessh Rawal, David Howard Williams, Donald Stuart Middleton, Michelle Y. Platts, Juin Fok-Seang, Manos Perros, Frederick Calo, Duncan Hay, Christopher Pickford, David R. Fenwick, Tram T. Tran, Hannah Vuong, Fiona M. Adam, Iain Gardner, Tanya Parkinson, Peter T. Stephenson, Amy Randall
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
The synthesis and structure-activity relationship of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36, a potent gp120-CD4 inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0315d777c77dc2ffe5cf5ff5806e52ce
https://pubmed.ncbi.nlm.nih.gov/19632839
https://pubmed.ncbi.nlm.nih.gov/19632839
Autor:
Juin Fok-Seang, David R. Fenwick, Iain Gardner, Tanya Parkinson, Mike Westby, Tram T. Tran, Manos Perros, Peter T. Stephenson, Don Middleton, David Howard Williams, Chris Pickford
Publikováno v:
Antiviral Research. 78:A25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f6f0e8ab773e75ad8b5c5e9c4378df1
https://doi.org/10.1016/j.antiviral.2008.01.038
https://doi.org/10.1016/j.antiviral.2008.01.038