Zobrazeno 1 - 10
of 34
pro vyhledávání: '"David Homolka"'
Autor:
Michaela Dohnalkova, Kyrylo Krasnykov, Mateusz Mendel, Lingyun Li, Olesya Panasenko, Fabienne Fleury-Olela, Cathrine Broberg Vågbø, David Homolka, Ramesh S. Pillai
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112786- (2023)
Summary: Eukaryotic RNA pol II transcripts are capped at the 5′ end by the methylated guanosine (m7G) moiety. In higher eukaryotes, CMTR1 and CMTR2 catalyze cap-proximal ribose methylations on the first (cap1) and second (cap2) nucleotides, respect
Externí odkaz:
https://doaj.org/article/b5fb7d507b834a0db489304cbd36a63c
Autor:
Rong Liu, Seth D. Kasowitz, David Homolka, N. Adrian Leu, Jordan T. Shaked, Gordon Ruthel, Devanshi Jain, Huijuan Lin, Scott Keeney, Mengcheng Luo, Ramesh S. Pillai, P. Jeremy Wang
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110110- (2021)
Summary: Mechanisms driving the prolonged meiotic prophase I in mammals are poorly understood. RNA helicase YTHDC2 is critical for mitosis to meiosis transition. However, YTHDC2 is highly expressed in pachytene cells. Here we identify an essential ro
Externí odkaz:
https://doaj.org/article/5e6e1c32c1214f81825e5a7b07b206dd
Autor:
Hao Wu, Lingyun Li, Kuan-Ming Chen, David Homolka, Pascal Gos, Fabienne Fleury-Olela, Andrew A. McCarthy, Ramesh S. Pillai
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4422-4434.e13 (2019)
Summary: RNA polymerase II transcripts receive a protective 5ʹ,5ʹ-triphosphate-linked 7-methylguanosine (m7G) cap, and its removal by decapping enzymes like DCP2 is critical for initiation of RNA decay. Alternative RNA caps can be acquired when tra
Externí odkaz:
https://doaj.org/article/80fcc94dbe644df886fa950c3301f007
Autor:
Radha Raman Pandey, David Homolka, Opeyemi Olotu, Ravi Sachidanandam, Noora Kotaja, Ramesh S. Pillai
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3423-3432.e4 (2018)
Summary: PIWI proteins and their associated small RNAs, called PIWI-interacting RNAs (piRNAs), restrict transposon activity in animal gonads to ensure fertility. Distinct biogenesis pathways load piRNAs into the PIWI proteins MILI and MIWI2 in the mo
Externí odkaz:
https://doaj.org/article/b7f187d74e2c43ef868a295f7e590d52
Autor:
David Homolka, Radha Raman Pandey, Coline Goriaux, Emilie Brasset, Chantal Vaury, Ravi Sachidanandam, Marie-Odile Fauvarque, Ramesh S. Pillai
Publikováno v:
Cell Reports, Vol 12, Iss 3, Pp 418-428 (2015)
PIWI proteins and PIWI-interacting RNAs (piRNAs) mediate repression of transposons in the animal gonads. Primary processing converts long single-stranded RNAs into ∼30-nt piRNAs, but their entry into the biogenesis pathway is unknown. Here, we demo
Externí odkaz:
https://doaj.org/article/48fbdcf71dbe437e8c15f9ba8508f823
Autor:
Radha Raman Pandey, David Homolka, Kuan-Ming Chen, Ravi Sachidanandam, Marie-Odile Fauvarque, Ramesh S Pillai
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006956 (2017)
Small RNAs called PIWI -interacting RNAs (piRNAs) are essential for transposon control and fertility in animals. Primary processing is the small RNA biogenesis pathway that uses long single-stranded RNA precursors to generate millions of individual p
Externí odkaz:
https://doaj.org/article/4d9c76e00d174d1389865dc1dbb86a82
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17198 (2011)
BACKGROUND: Tight regulation of testicular gene expression is a prerequisite for male reproductive success, while differentiation of gene activity in spermatogenesis is important during speciation. Thus, comparison of testicular transcriptomes betwee
Externí odkaz:
https://doaj.org/article/a5bc52a435d44687b238d8176fc4bb5a
Autor:
Giulia Franco, Emmanuel Taillebourg, Elena Delfino, David Homolka, Nathalie Gueguen, Emilie Brasset, Radha Raman Pandey, Ramesh S. Pillai, Marie-Odile Fauvarque
Publikováno v:
RNA. 29:609-619
Eukaryotic mRNAs are modified at the 5′ end with a methylated guanosine (m7G) that is attached to the transcription start site (TSS) nucleotide. The TSS nucleotide is 2′-O-methylated (Nm) by CMTR1 in organisms ranging from insects to human. In ma
Autor:
Opeyemi Olotu, Mark Dowling, David Homolka, Magdalena N. Wojtas, Panyi Tran, Tiina Lehtiniemi, Matteo Da Ros, Ramesh S. Pillai, Noora Kotaja
Publikováno v:
Andrology. 11:710-723
Background Germ granules are large cytoplasmic ribonucleoprotein complexes that emerge in the germline to participate in RNA regulation. The two most prominent germ granules are the intermitochondrial cement (IMC) in meiotic spermatocytes and the chr
Publikováno v:
RNA (New York, N.Y.).
Argonautes are small RNA-binding proteins, with some having small RNA-guided endonuclease (slicer) activity that cleaves target nucleic acids. One cardinal rule that is structurally defined is the inability of slicers to cleave target RNAs when nucle