Zobrazeno 1 - 10
of 12
pro vyhledávání: '"David Hercules"'
Publikováno v:
bioRxiv
Nuclear receptors (NRs) are transcription factors that regulate essential biological processes in response to cognate ligands. An important part of NR function involves ligand-induced conformational changes that recruit coregulator proteins to the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8502aeb3ad284ace195748230d6b6412
https://europepmc.org/articles/PMC9900875/
https://europepmc.org/articles/PMC9900875/
Autor:
Marx, David Hercules
Continued population growth is placing strain on the waste disposal facilities available in South Africa. However, limited air space suitable for landfilling drives the need for alternative solutions such as piggyback landfills to expand the waste di
Externí odkaz:
http://hdl.handle.net/2263/60633
Autor:
David Hercules, Jennifer K. Colucci, Eric A. Ortlund, S. H. Khan, Joseph W. Thornton, K. Cottrill, Michael L. Cato, Geeta N. Eick, C. D. Okafor
The genetic and biophysical mechanisms by which new protein functions evolve are central concerns in evolutionary biology and molecular evolution. Despite much speculation, we know little about how protein function evolves. Here, we use ancestral pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b90db6bda2dcd8b29583e5a4b580540a
https://doi.org/10.1101/2021.07.21.453223
https://doi.org/10.1101/2021.07.21.453223
Autor:
Scott B. Snapper, Anil G. Jegga, Nicholas J Ollberding, Marla Dubinsky, Marian D. Pfefferkorn, James Markowitz, Jason Shapiro, Robert Baldassano, Lee A. Denson, Jonathan R Dillman, Subra Kugathasan, Maria Oliva-Hemker, Adina Alazraki, David Hercules, Anthony R. Otley, Melvin B. Heyman, Ramnik J. Xavier, Allison Ta, Rebekah Karns, Yael Haberman, Jeffrey S. Hyams, Joshua D. Noe, Sandra C. Kim, Barbara S. Kirschner, Shervin Rabizadeh, Richard Kellermayer
Publikováno v:
Inflamm Bowel Dis
Inflammatory bowel diseases, vol 27, iss 11
Inflammatory bowel diseases, vol 27, iss 11
Background Transmural healing (TH) is associated with better long-term outcomes in Crohn disease (CD), whereas pretreatment ileal gene signatures encoding myeloid inflammatory responses and extracellular matrix production are associated with strictur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94429f2a5b5355b4b8094655eb806d1f
https://europepmc.org/articles/PMC8528150/
https://europepmc.org/articles/PMC8528150/
Autor:
Duke Geem, David Hercules, Suresh Venkateswaran, Ranjit S. Pelia, Jeffrey S. Hyams, Lee A. Denson, Subra Kugathasan
Publikováno v:
Gastroenterology. 162:S-122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6ec8ac98aeacc6a8d7df3318efa5931
https://doi.org/10.1016/s0016-5085(22)60298-1
https://doi.org/10.1016/s0016-5085(22)60298-1
Autor:
Shaohong Yang, David Hercules, Christina Ha, Gil Y. Melmed, Emebet Mengesha, Shishir Dube, Dalin Li, Gregory J. Botwin, Millie D. Long, Judy H. Cho, Shervin Rabizadeh, R. Balfour Sartor, Steven R. Brant, Bana Jabri, Richard H. Duerr, Eric A. Vasiliauskas, Ashwin N. Ananthakrishnan, William A. Faubion, David Ziring, John D. Rioux, Dermot P.B. McGovern, Stephan R. Targan, Michelle Khrom, Robert S. Sandler, L. Philip Schumm, Nirupama Bonthala, Mark S. Silverberg, Talin Haritunians, Subra Kugathasan, Sergio A. Lira, Rodney D. Newberry, Ramnik J. Xavier, Gaurav Syal
Publikováno v:
Gastroenterology. 160:S-516
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67578275ddbed00b6d72cc3178a32b2d
https://doi.org/10.1016/s0016-5085(21)01938-7
https://doi.org/10.1016/s0016-5085(21)01938-7
Publikováno v:
Structure. 28:196-205.e3
Understanding how changes in amino acid sequence alter protein dynamics and allosteric signaling would illuminate strategies for protein design. To gain insight into this process, we have combined molecular dynamics simulations with ancestral sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695ecc068fd873e7b8d129abeb27148c
https://doi.org/10.1016/j.str.2019.11.012
https://doi.org/10.1016/j.str.2019.11.012
Autor:
DebraLynn, Mims, David, Hercules
Publikováno v:
Analytical and Bioanalytical Chemistry. 378:1322-1326
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (MS) has proved to be a useful method for the quantification of bile acids directly from plasma. Six cholic acid derivatives were selected for analysis: taurocholic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d263803843bc619c7b2b726da05dd06
https://doi.org/10.1007/s00216-003-2475-z
https://doi.org/10.1007/s00216-003-2475-z