Zobrazeno 1 - 10 of 13 pro vyhledávání: '"David Henault"'
1
Akademický článek
Radiomics using computed tomography to predict CD73 expression and prognosis of colorectal cancer liver metastases
Autor: Ralph Saber, David Henault, Nouredin Messaoudi, Rolando Rebolledo, Emmanuel Montagnon, Geneviève Soucy, John Stagg, An Tang, Simon Turcotte, Samuel Kadoury
Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Finding a noninvasive radiomic surrogate of tumor immune features could help identify patients more likely to respond to novel immune checkpoint inhibitors. Particularly, CD73 is an ectonucleotidase that catalyzes the breakdown of
Externí odkaz: https://doaj.org/article/aae54557d28548c1ac9911badaa56469
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2
Akademický článek
Homogeneity in immune features between colorectal liver metastases better identifies patients with good prognosis compared to pathological response to preoperative chemotherapy
Autor: David Henault, David Stephen, Pierre-Antoine St-Hilaire, Nouredin Messaoudi, Franck Vandenbroucke-Menu, Eve Simoneau, Zhixia Rong, Marylène Plasse, Richard Létourneau, André Roy, Michel Dagenais, Réal Lapointe, Bich Nguyen, Anne-Marie Mes-Masson, G. Soucy, Simon Turcotte
Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTIn colorectal cancer liver metastases (CRLM), the density of tumor-infiltrating lymphocytes, the expression of class I major histocompatibility complex (MHC-I), and the pathological response to preoperative chemotherapy have been associated w
Externí odkaz: https://doaj.org/article/f7d6612e7f864920847bd437adcab85f
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3
Akademický článek
Prognostic value of CD73 expression in resected colorectal cancer liver metastasis
Autor: Nouredin Messaoudi, Isabelle Cousineau, Elizabeth Arslanian, David Henault, David Stephen, Franck Vandenbroucke-Menu, Michel Dagenais, Richard Létourneau, Marylène Plasse, André Roy, Réal Lapointe, Dirk Ysebaert, Dominique Trudel, Geneviève Soucy, John Stagg, Simon Turcotte
Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)
Immune checkpoint blockade has not yet been effective in patients with mismatch repair proficient metastatic colorectal cancer. Targeting immunosuppressive metabolic pathways is being explored as a new immunotherapeutic approach. We assessed whether
Externí odkaz: https://doaj.org/article/a33e281651764b35a08a7c56c70ff606
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6
302 Characterization of TIGIT and PVR expression in colorectal liver metastases
Autor: Benoit Barrette, Antoine Bernard, Simon Turcotte, Pamela Thebault, David Henault, Sandy Pelletier
Publikováno v: Journal for ImmunoTherapy of Cancer. 9:A325-A325
BackgroundMetastatic colorectal cancer (CRC) is common and lethal and generally not responsive to current immunotherapies. We hypothesize that efficacious T cell-based immunotherapy can be developed for this malignancy, provided that immune checkpoin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d453bc8cf5ffc8d446dfeee3f8c83e83
https://doi.org/10.1136/jitc-2021-sitc2021.302
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8
Divergence from osteoporosis screening guidelines in older breast cancer patients treated with anti-estrogen therapy: A population-based cohort study
Autor: David Henault, Sue-Ling Chang, Sinziana Dumitra, Robyn Tamblyn, Tracy Westley, Richard Kremer, Ari N. Meguerditchian, Nancy E. Mayo
Publikováno v: Bone. 116
Purpose Older Breast Cancer (BC) survivors are an increased risk of osteoporosis due to natural aging and long-term cancer treatment-related toxicity. It is well known that anti-estrogen therapy (AET), especially aromatase inhibitors (AI), is associa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12fbf12da8c8d64adc48596f836be3c
https://pubmed.ncbi.nlm.nih.gov/29981903
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9
Abstract 579: Immune features and neoantigen recognition in mismatch repair-proficient colorectal cancer liver metastases
Autor: Steven Hébert, Mélissa Mathieu, David Henault, Maud Marques, Éric Audemard, Mathieu Courcelles, Scott D. Brown, Pratyaksha Wirapati, Sabine Tejpar, Michael I. D'Angelica, Robert A. Holt, Sylvie Mader, Pierre Thibault, Gerald Batist, Claudia Kleinman, Simon Turcotte
Publikováno v: Cancer Research. 79:579-579
Immunotherapy for patients with non-highly mutated, mismatch repair-proficient (MMRprof) metastatic colorectal cancer has largely been unsuccessful thus far. Here, we used transcriptomics, genomics and in vitro analyses to study the adaptive immune f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d3aea0541d6ab82cb4382fd3d809e53
https://doi.org/10.1158/1538-7445.am2019-579
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10
Basis for fluctuations in lymphocyte counts in fingolimod-treated patients with multiple sclerosis
Autor: David Henault, Trina A. Johnson, Lorna Galleguillos, Amit Bar-Or, Jack P. Antel, Craig S. Moore
Publikováno v: Neurology. 81:1768-1772
Objective: To determine the range of fluctuation in total lymphocyte counts (TLCs) in peripheral blood over a 4- to 7-year period in patients with MS receiving fingolimod (FTY720) and the relation between TLCs and T-cell subsets (CD4+, CD8+, CCR7+/
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d77c0fc4189c0dd75ca4d4a9cf4c679
https://doi.org/10.1212/01.wnl.0000435564.92609.2c
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