Zobrazeno 1 - 10
of 34
pro vyhledávání: '"David Heal"'
Publikováno v:
Exploration of Neuroprotective Therapy, Vol 4, Iss 4, Pp 325-348 (2024)
Neuroinflammation can be caused by disease, aging, infection, brain injury, toxicity, or stress. It is a contributory factor in the neuropathology of serious conditions that include multiple sclerosis (MS), Alzheimer’s disease, Parkinson’s diseas
Externí odkaz:
https://doaj.org/article/4db317a1be8a42d5a122dab91646f111
Autor:
Chloe Engler Hart, António José Preto, Shaurya Chanana, David Healey, Tobias Kind, Daniel Domingo-Fernández
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Ion Mobility coupled with Mass Spectrometry (IM-MS) is a promising analytical technique that enhances molecular characterization by measuring collision cross-section (CCS) values, which are indicative of the molecular size and shape. However
Externí odkaz:
https://doaj.org/article/b355a92d23be450180c06177219466ee
Autor:
Filomene Morrison, Lori Jean Van Orden, Karla Zeitz, David Heal, Sharon Smith, Tanya L. Wallace
Publikováno v:
Biological Psychiatry. 93:S184
Publikováno v:
Journal of psychopharmacology (Oxford, England). 36(7)
Autor:
Daniel Domingo-Fernández, Yojana Gadiya, Sarah Mubeen, David Healey, Bryan H. Norman, Viswa Colluru
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Plants are one of the primary sources of natural products for drug development. However, despite centuries of research, only a limited region of the phytochemical space has been studied. To understand the scope of what is explored versus une
Externí odkaz:
https://doaj.org/article/7977806c40034dc7a7e747df3e6f8fae
Autor:
Essam Metwally, Victor Mak, Aileen Soriano, Matthias Zebisch, H. Leonardo Silvestre, Paul A. McEwan, Grigori Ermakov, Maribel Beaumont, Paul Tawa, John J. Barker, Rose Yen, Akash Patel, Yeon-Hee Lim, David Healy, Jennifer Hanisak, Alan C. Cheng, Tom Greshock, Thierry O. Fischmann
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract cGMP-dependent protein kinase I-α (PKG1α) is a target for pulmonary arterial hypertension due to its role in the regulation of smooth muscle function. While most work has focused on regulation of cGMP turnover, we recently described severa
Externí odkaz:
https://doaj.org/article/35e2c7e8e424458aafb60de67b006cea
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Better understanding the transcriptomic response produced by a compound perturbing its targets can shed light on the underlying biological processes regulated by the compound. However, establishing the relationship between the induced transc
Externí odkaz:
https://doaj.org/article/00519618986a4f59a90f9042aca43a63
Autor:
David Healy, Dee Mangin
Publikováno v:
Epidemiology and Psychiatric Sciences, Vol 33 (2024)
While sexual dysfunction is a well-known side effect of taking selective serotonin reuptake inhibitors (SSRIs), in an undetermined number of patients, sexual function does not return to pre-drug baseline after stopping SSRIs. The condition is known a
Externí odkaz:
https://doaj.org/article/5564d5a3accb4b1a97883cc68d5e5655
Autor:
Eugene M Dempsey, Shuo Wang, David Healy, Catherine Stanton, Paul Ross, Ghjuvan Grimaud, Alicja Katarzyna Warda
Publikováno v:
BMJ Open, Vol 13, Iss 9 (2023)
Introduction Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and fee
Externí odkaz:
https://doaj.org/article/0a3f7c52492542e1bf7758554a8c49f2
Autor:
David Healy
Publikováno v:
Therapeutic Advances in Psychopharmacology, Vol 13 (2023)
In current medical practice, it is difficult to find any reports claiming that drugs that are primarily anticholinergic or those that have significant anticholinergic effects have any therapeutic benefits. These drugs fell into disrepute within the m
Externí odkaz:
https://doaj.org/article/5d0f2b19d80941fa8f6d3a01103b2543