Zobrazeno 1 - 10
of 121
pro vyhledávání: '"David Hahn"'
Autor:
Leonardo Medrano Sandonas, Dries Van Rompaey, Alessio Fallani, Mathias Hilfiker, David Hahn, Laura Perez-Benito, Jonas Verhoeven, Gary Tresadern, Joerg Kurt Wegner, Hugo Ceulemans, Alexandre Tkatchenko
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-14 (2024)
Abstract We here introduce the Aquamarine (AQM) dataset, an extensive quantum-mechanical (QM) dataset that contains the structural and electronic information of 59,783 low-and high-energy conformers of 1,653 molecules with a total number of atoms ran
Externí odkaz:
https://doaj.org/article/3d893d555633424da5b765b5e366cd8d
Autor:
Nicholas Spellmon, Artur Muszyński, Ireneusz Górniak, Jiri Vlach, David Hahn, Parastoo Azadi, Jochen Zimmer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Gram negative microbes strategically equip lipopolysaccharides with O antigens to expand the extracellular envelope. Here, the authors examine how the O antigen is captured by a special class of ABC transporters containing a carbohydrate-binding modu
Externí odkaz:
https://doaj.org/article/f351dd5029a24ec6aa893c69d590cdab
Autor:
Stephanie A. Mayers, Sarah K. Cook, Caitlin Rantala, Tiffany Israel, Tara Helmer, Matt Schorr, Guadalupe Campos, David Hahn, Pamela Pimentel, Mysha Wynn, Terri L. Edwards, Mary Stroud, Paul A. Harris, Consuelo H. Wilkins
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Clinical trials face many challenges with meeting projected enrollment and retention goals. A study’s recruitment materials and messaging convey necessary key information and therefore serve as a critical first impression with potential participant
Externí odkaz:
https://doaj.org/article/529a6bdd8f324d22bcd894522faa5bd9
Autor:
Chie Emoto, Trevor N. Johnson, David Hahn, Uwe Christians, Rita R. Alloway, Alexander A. Vinks, Tsuyoshi Fukuda
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 273-284 (2019)
Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A P
Externí odkaz:
https://doaj.org/article/2417614322424306a3f5384a8e116391
Autor:
Chie Emoto, Trevor N. Johnson, Sibylle Neuhoff, David Hahn, Alexander A. Vinks, Tsuyoshi Fukuda
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 7, Pp 464-473 (2018)
Morphine has large pharmacokinetic variability, which is further complicated by developmental changes in neonates and small infants. The impacts of organic cation transporter 1 (OCT1) genotype and changes in blood‐flow on morphine clearance (CL) we
Externí odkaz:
https://doaj.org/article/6eba7d5d81b146268ee380e8e8eee12d
Autor:
David Hahn, Lukas Lätsch
Publikováno v:
CHIMIA, Vol 72, Iss 1-2 (2018)
Externí odkaz:
https://doaj.org/article/8bac07a81ac34a19a50660a39553fe78
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62915 (2013)
Simultaneous recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) has shown a number of advantages that make this multimodal technique superior to fMRI alone. The feasibility of recording EEG at ultra-high static
Externí odkaz:
https://doaj.org/article/b3aa5fa6345146269da733bfe08ebae5
Publikováno v:
Journal of Chemical Information and Modeling. 63:1776-1793
Drug discovery is accelerated with computational methods such as alchemical simulations to estimate ligand affinities. In particular, relative binding free energy (RBFE) simulations are beneficial for lead optimization. To use RBFE simulations to com
Autor:
Feng Yin, Chris DeCiantis, Jan Pinkas, Biplab Das, Frank Wang, Nancy Zheng, David Hahn, Aniruddha Amrite, Diana Adhikari, Cheikh Kane, Jack Sikora, Justin Pittman, Rebecca Wates, Elizabeth Shaheen, Shawn Harriman
Publikováno v:
Bioanalysis. 15:43-52
Aim: PYX-201 is a novel antibody–drug conjugate targeting the extra domain B splice variant of fibronectin in the tumor microenvironment. Accurate quantification of PYX-201 is critical for PYX-201 pharmacokinetics profiling in preclinical studies.
Autor:
Michael Wimmer, Iva Kovacic, Peter Ferschin, Florian Rist, Michael Hensel, Kristina Schinegger, Stefan Rutzinger, Hannes Kaufmann, Martin Kilian, Christian Müller, Ivan Izmestiev, Georg Nawratil, Josef Füssl, Milena Stavric, David Hahn, Georg Suter
Publikováno v:
Bautechnik. 99:720-730