Zobrazeno 1 - 10
of 359
pro vyhledávání: '"David H. Wasserman"'
Autor:
Vishal Musale, Colin E. Murdoch, Ayman K. Banah, Annie Hasib, Chandani K. Hennayake, Bo Dong, Chim C. Lang, David H. Wasserman, Li Kang
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101970- (2024)
Objective: Obesity increases deposition of extracellular matrix (ECM) components of cardiac tissue. Since obesity aggregates with insulin resistance and heart disease, it is imperative to determine whether the increased ECM deposition contributes to
Externí odkaz:
https://doaj.org/article/a263f7a9365d413da8217d61d8a513a5
Autor:
Tomasz K. Bednarski, Mohsin Rahim, Clinton M. Hasenour, Deveena R. Banerjee, Irina A. Trenary, David H. Wasserman, Jamey D. Young
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100558- (2024)
Metabolic dysfunction-associated steatotic liver disease is the most common form of liver disease and poses significant health risks to patients who progress to metabolic dysfunction-associated steatohepatitis. Fatty acid overload alters endoplasmic
Externí odkaz:
https://doaj.org/article/c47f295c40d14743bbad10fcd129e345
Autor:
Nathan C. Winn, Michael W. Schleh, Jamie N. Garcia, Louise Lantier, Owen P. McGuinness, Joslin A. Blair, Alyssa H. Hasty, David H. Wasserman
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101901- (2024)
Mammals are protected from changes in environmental temperature by altering energetic processes that modify heat production. Insulin is the dominant stimulus of glucose uptake and metabolism, which are fundamental for thermogenic processes. The purpo
Externí odkaz:
https://doaj.org/article/2f51ca3484694f5b8883840b5ba0654e
Autor:
Yu Pan, Shirong Cao, Jiaqi Tang, Juan P. Arroyo, Andrew S. Terker, Yinqiu Wang, Aolei Niu, Xiaofeng Fan, Suwan Wang, Yahua Zhang, Ming Jiang, David H. Wasserman, Ming-Zhi Zhang, Raymond C. Harris
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Obesity-associated complications are causing increasing morbidity and mortality worldwide. Expansion of adipose tissue in obesity leads to a state of low-grade chronic inflammation and dysregulated metabolism, resulting in insulin resistance and meta
Externí odkaz:
https://doaj.org/article/a0b198a8263149cbb92a61b14b9798b9
Autor:
Aimée R. Bugler-Lamb, Annie Hasib, Xiong Weng, Chandani K. Hennayake, Chenshi Lin, Rory J. McCrimmon, Roland H. Stimson, Michael L.J. Ashford, David H. Wasserman, Li Kang
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101197- (2021)
Objective: Increased deposition of the extracellular matrix (ECM) in adipose tissue (AT) during obesity contributes to insulin resistance. The integrin receptors transmit changes in the extracellular environment causing corresponding intracellular ad
Externí odkaz:
https://doaj.org/article/ceb76794140e453f96fb9d477902bccb
Autor:
Mohsin Rahim, Clinton M. Hasenour, Tomasz K. Bednarski, Curtis C. Hughey, David H. Wasserman, Jamey D. Young
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
The liver is the major source of glucose production during fasting under normal physiological conditions. However, the kidney may also contribute to maintaining glucose homeostasis in certain circumstances. To test the ability of the kidney to compen
Externí odkaz:
https://doaj.org/article/e38a1f84ddad44a6850efd5dbd70d9e4
Publikováno v:
Molecular Metabolism, Vol 23, Iss , Pp 1-13 (2019)
Objective: The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the transition to hepatocellular carcinoma (HCC). Previous work showed endogenous glucose production is reduced in GNMT-null mice with gluconeogenic precurso
Externí odkaz:
https://doaj.org/article/00bb0f0ed7b5409481f30bc8c339a195
Autor:
Lin Zhu, Jeanne Shi, Thao N. Luu, Joshua C. Neuman, Elijah Trefts, Sophia Yu, Brian T. Palmisano, David H. Wasserman, MacRae F. Linton, John M. Stafford
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 106-116 (2018)
Objective: Hepatocyte deletion of estrogen receptor alpha (LKO-ERα) worsens fatty liver, dyslipidemia, and insulin resistance in high-fat diet fed female mice. However, whether or not hepatocyte ERα regulates reverse cholesterol transport (RCT) in
Externí odkaz:
https://doaj.org/article/280e1ee22eac4ce5bbf61622a910d72b
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5738 (2020)
Aberrant extracellular matrix (ECM) remodelling in muscle, liver and adipose tissue is a key characteristic of obesity and insulin resistance. Despite its emerging importance, the effective ECM targets remain largely undefined due to limitations of c
Externí odkaz:
https://doaj.org/article/1e89c72274164cf4a0564789d2bdd650
Autor:
Daniel S. Lark, David H. Wasserman
Publikováno v:
F1000Research, Vol 6 (2017)
Obesity and insulin resistance often emerge from positive energy balance and generally are linked to low-grade inflammation. This low-grade inflammation has been called “meta-inflammation” because it is a consequence of the metabolic dysregulatio
Externí odkaz:
https://doaj.org/article/ec9dca1daec54f37874f439b267f7949