Zobrazeno 1 - 10
of 141
pro vyhledávání: '"David H. Sherr"'
Autor:
Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernández-Salguero, Xavier Coumoul, Andrew D. Patterson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5550 (2023)
The aryl hydrocarbon receptor (AHR) is a sensor of low-molecular-weight molecule signals that originate from environmental exposures, the microbiome, and host metabolism. Building upon initial studies examining anthropogenic chemical exposures, the l
Externí odkaz:
https://doaj.org/article/51868d43c72e45e9b088150fefa88fb8
Autor:
Hossam T. Mohamed, Ramy Gadalla, Noura El-Husseiny, Hebatallah Hassan, Zhongyan Wang, Sherif A. Ibrahim, Mohamed El-Shinawi, David H. Sherr, Mona M. Mohamed
Publikováno v:
Journal of Advanced Research, Vol 16, Iss , Pp 75-86 (2019)
The aim of the present study was to evaluate the expression levels of the aryl hydrocarbon receptor (AHR) and its target gene CYP1B1 and to correlate their expression with Wnt5a/b-β-catenin, the CD44+/CD24(−/low) cancer stem cell (CSC) subset and
Externí odkaz:
https://doaj.org/article/55caf65825e747b4bf584564a6844ac4
Autor:
Smitha Krishnan, Yufang Ding, Nima Saedi, Maria Choi, Gautham V. Sridharan, David H. Sherr, Martin L. Yarmush, Robert C. Alaniz, Arul Jayaraman, Kyongbum Lee
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1099-1111 (2018)
Summary: The gut microbiota plays a significant role in the progression of fatty liver disease; however, the mediators and their mechanisms remain to be elucidated. Comparing metabolite profile differences between germ-free and conventionally raised
Externí odkaz:
https://doaj.org/article/b605879bd89849c7a6e05d6bee4c7e7c
Autor:
Peter E. A. Ash, Elizabeth A. Stanford, Ali Al Abdulatif, Alejandra Ramirez-Cardenas, Heather I. Ballance, Samantha Boudeau, Amanda Jeh, James M. Murithi, Yorghos Tripodis, George J. Murphy, David H. Sherr, Benjamin Wolozin
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-14 (2017)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition that is characterized by progressive loss of motor neurons and the accumulation of aggregated TAR DNA Binding Protein-43 (TDP-43, gene: TARDBP). Inc
Externí odkaz:
https://doaj.org/article/918a0164aa8e4ba8b9e5f89dd64cfaf5
Autor:
Zhongyan Wang, Megan Snyder, Jessica E. Kenison, Kangkang Yang, Brian Lara, Emily Lydell, Kawtar Bennani, Olga Novikov, Anthony Federico, Stefano Monti, David H. Sherr
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 387 (2020)
For decades, the aryl hydrocarbon receptor (AHR) was studied for its role in environmental chemical toxicity i.e., as a quirk of nature and a mediator of unintended consequences of human pollution. During that period, it was not certain that the AHR
Externí odkaz:
https://doaj.org/article/4c17215a4f134a73b2bb53a6d58c7cf0
Autor:
Charlotte Esser, B. Paige Lawrence, David H. Sherr, Gary H. Perdew, Alvaro Puga, Robert Barouki, Xavier Coumoul
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3603 (2018)
In a time where “translational„ science has become a mantra in the biomedical field, it is reassuring when years of research into a biological phenomenon suddenly points towards novel prevention or therapeutic approaches to disease, thereby demon
Externí odkaz:
https://doaj.org/article/5e8ec74bb2d4433482dfe997a2108879
Publikováno v:
Stem Cells International, Vol 2016 (2016)
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that increases the expression of detoxifying enzymes upon ligand stimulation. Recent studies now suggest that novel endogenous roles of the AHR exist throughout developmen
Externí odkaz:
https://doaj.org/article/377cd6377cae445d82f756f7ca529a32
Autor:
Supraja Narasimhan, Elizabeth Stanford Zulick, Olga Novikov, Ashley J. Parks, Jennifer J. Schlezinger, Zhongyan Wang, Fabrice Laroche, Hui Feng, Francesca Mulas, Stefano Monti, David H. Sherr
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 5, p 1388 (2018)
We have postulated that the aryl hydrocarbon receptor (AHR) drives the later, more lethal stages of some cancers when chronically activated by endogenous ligands. However, other studies have suggested that, under some circumstances, the AHR can oppos
Externí odkaz:
https://doaj.org/article/75f920ff3507453dab4ee274a2be4b58
Autor:
David H. Sherr, Manish V. Bais, Stefano Monti, Maria Kukuruzinska, Caroline A. Genco, Joseph P. Mizgerd, Petros Koutrakis, Khalid Alamoud, Olga Novikov, Zhongyan Wang, Alejandra Ramirez-Cardenas, Elizabeth A. Stanford
Expression of AHR in whole cell lysates from HSC-3 and Cal27 cells was determined by Western immunoblot analysis, using AhR-specific (1:1000, 13790#, Cell signaling), and β-actin-specific (1:2000, A5441, Sigma-Aldrich) antibodies. Cell lysates from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d35b21c9b15aedeb1cc74449acadbba
https://doi.org/10.1158/1541-7786.22511620.v1
https://doi.org/10.1158/1541-7786.22511620.v1
Autor:
David H. Sherr, Manish V. Bais, Stefano Monti, Maria Kukuruzinska, Caroline A. Genco, Joseph P. Mizgerd, Petros Koutrakis, Khalid Alamoud, Olga Novikov, Zhongyan Wang, Alejandra Ramirez-Cardenas, Elizabeth A. Stanford
Over 45,000 new cases of oral and pharyngeal cancers are diagnosed and account for over 8,000 deaths a year in the United States. An environmental chemical receptor, the aryl hydrocarbon receptor (AhR), has previously been implicated in oral squamous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d81e730bd7216f3e994548a7d782b4c5
https://doi.org/10.1158/1541-7786.c.6539992.v1
https://doi.org/10.1158/1541-7786.c.6539992.v1