Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David H. Randle"'
Publikováno v:
Current Protocols in Chemical Biology
Label-free cell-based assays offer a powerful approach to drug discovery and compound profiling for endogenously expressed receptors in a variety of cell types, including primary and stem cells. Dynamic mass redistribution (DMR) responses in whole ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f788310a64547d0e3f15a69cdb8dd724
https://doi.org/10.1002/9780470559277.ch130205
https://doi.org/10.1002/9780470559277.ch130205
The driving need for productivity improvement in drug discovery and development has accelerated the development of advanced cellular models that better mimic the in vivo physiology of living tissues and organisms. The past decades have witnessed an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a83cdd7d2212dd5de1cbb449aa19d0b
https://doi.org/10.1039/9781782626770-00239
https://doi.org/10.1039/9781782626770-00239
Autor:
Richard M. Eglen, David H. Randle
Publikováno v:
Assay and drug development technologies. 13(5)
Immortalized cells, generated from two-dimensional cell culture techniques, are widely used in compound screening, lead optimization, and drug candidate selection. However, such cells lack many characteristics of cells in vivo. This could account for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcc44afe05f2ed84e6d248f085ac175
https://pubmed.ncbi.nlm.nih.gov/26121065
https://pubmed.ncbi.nlm.nih.gov/26121065
Autor:
Christian C. Felder, Audrey B. Bergeron, David H. Randle, Hannah J. Gitschier, Melvyn Baez, Paul Goldsmith, Lisa M. Broad, Caryn E. Bacon, Douglas A. Schober, Peiyi Yang
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781493926169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::251a65f7bdd703f8e397cbb35002bcdf
https://doi.org/10.1007/978-1-4939-2617-6_11
https://doi.org/10.1007/978-1-4939-2617-6_11
Autor:
Takehiko Kamijo, John L. Cleveland, David H. Randle, Martine F. Roussel, Frederique Zindy, Charles J. Sherr, Christine M. Eischen
Publikováno v:
Genes & Development. 12:2424-2433
Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of the p53 or p19ARF tumor suppressors, which act in a common biochemical pathway. myc rapidly activates ARF andp53 gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c59a61b8bcae6cf8037ad61a82a1d1
https://doi.org/10.1101/gad.12.15.2424
https://doi.org/10.1101/gad.12.15.2424
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90e113088b5a25cb6073b28b5771a094
https://doi.org/10.1096/fasebj.27.1_supplement.1181.6
https://doi.org/10.1096/fasebj.27.1_supplement.1181.6
Publikováno v:
Genesdevelopment. 15(22)
Induction of p53-dependent transcription after genotoxic stress or oncogene activation leads to expression of genes that trigger either cell cycle arrest or apoptosis, thereby guarding against tumor formation (Levine 1997). The central role of p53 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f3bb2498acfde396a01eaefe7a5819
https://pubmed.ncbi.nlm.nih.gov/11711428
https://pubmed.ncbi.nlm.nih.gov/11711428
Autor:
Gerard P. Zambetti, David H. Randle, Jason D. Weber, John R. Jeffers, Martine F. Roussel, Charles J. Sherr, Jerold E. Rehg, Guillermina Lozano
The p19ARF tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop multiple tumors at a frequency greater than those observed in animals lacking bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3765e3d1986cd0e0ab53b477be0fd385
https://europepmc.org/articles/PMC316930/
https://europepmc.org/articles/PMC316930/
Autor:
Michael S. Cohen, Kevan M. Shokat, Jennifer Snead, David H. Randle, David O. Morgan, Jack Taunton, Michael B. Yaffe, Matt Sullivan, Chao Zhang, Drew M. Lowery
Publikováno v:
Chemistry & Biology. (11):1261-1272
Protein phosphorylation is a ubiquitous mechanism for cellular signal propagation, and signaling network complexity presents a challenge to protein kinase substrate identification. Few targets of Polo-like kinases are known, despite their significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6149f20791bb3dbe1e3b3807ba2e471d