Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David H. Peers"'
Autor:
Dave Brousseau, Judith A. Fox, Adriana Johnson, David H. Peers, Phillip W. Berman, Thomas Ryll, Sabrina Tom, Timothy A. Hotaling, Richard L. Gehant, Steven M. Chamow, Christiane Köhne
Publikováno v:
Journal of Cellular Biochemistry. 75:446-461
Strategies that prevent the attachment of N-linked carbohydrates to nascent glycoproteins often impair intracellular transport and secretion. In the present study, we describe a method to rescue the intracellular transport and secretion of glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f06ea37f2aff9cf1fa82969bc16abce8
https://doi.org/10.1002/(sici)1097-4644(19991201)75:3<446::aid-jcb10>3.0.co
https://doi.org/10.1002/(sici)1097-4644(19991201)75:3<446::aid-jcb10>3.0.co
Engineering Chinese hamster ovary cells to maximize sialic acid content of recombinant glycoproteins
Autor:
Lynne A. Krummen, David H. Peers, K. Carroll, S. Mehta, Damon I. Papac, Vanessa Chisholm, Nishit B. Modi, Martin Gawlitzek, S. Weikert, S. Tom, Steven M. Chamow, Phillip W. Berman, D. Cowfer, J. Briggs, J. Lofgren, S. Eppler
Publikováno v:
Nature Biotechnology. 17:1116-1121
We have engineered two Chinese hamster ovary cell lines secreting different recombinant glycoproteins to express high levels of human beta1,4-galactosyltransferase (GT, E.C. 2.4.1.38) and/or alpha2, 3-sialyltransferase (ST, E.C. 2.4.99.6). N-linked o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e918a6a35e9824dce64b3e05017ef032
https://doi.org/10.1038/15104
https://doi.org/10.1038/15104
Autor:
Helen Hsifei Chen, Napoleone Ferrara, Ralph H. Schwall, Vanessa Chisholm, David H. Peers, Kenneth J. Hillan, Hans-Peter Gerber, Thuy-Nhung Nguyen, Terri Lynn Davis-Smyth
Publikováno v:
Nature Medicine. 4:336-340
The development and endocrine function of the ovarian corpus luteum (CL) are dependent on the growth of new capillary vessels. Although several molecules have been implicated as mediators of CL angiogenesis, at present there is no direct evidence for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea4694da22735188e929a3a702e84cb
https://doi.org/10.1038/nm0398-336
https://doi.org/10.1038/nm0398-336
Autor:
Steven M. Chamow, Timothy P. Kogan, David H. Peers, Michael C. Venuti, Reed J. Harris, Joyce Mordenti, Steven Shak, Thomas Gadek, Avi Ashkenazi
Publikováno v:
Bioconjugate Chemistry. 5:133-140
CD4 immunoadhesin (CD4-IgG) is a chimeric glycoprotein molecule comprised of the gp120-binding portion of human CD4 fused to the hinge and Fc portions of human IgG. As a candidate for human therapeutic use, CD4-IgG represents an important advance ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f642304d37eccf9d6dd02cf6e971f17b
https://doi.org/10.1021/bc00026a005
https://doi.org/10.1021/bc00026a005
Autor:
Randal A. Byrn, Timothy P. Kogan, David H. Peers, Steven M. Chamow, Avi Ashkenazi, Richard C. Hastings
Publikováno v:
Journal of Biological Chemistry. 267:15916-15922
Chemical conjugates of recombinant soluble CD4 (sCD4) with toxins, or with antibodies that activate cytotoxic T cells, can be used to direct selective killing of human immunodeficiency virus (HIV)-infected cells. This approach takes advantage of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb767ae93ae99a4be6c13d03f14c2839
https://doi.org/10.1016/s0021-9258(19)49621-x
https://doi.org/10.1016/s0021-9258(19)49621-x
Autor:
Daniel J. Capon, Randal A. Byrn, Wen Ching Wang, Michael G. Mulkerrin, David H. Peers, Reed J. Harris, Avi Ashkenazi, Steven M. Chamow, Pamela J. Bjorkman
Publikováno v:
Biochemistry. 29:9885-9891
CD4, the cell-surface receptor for the human immunodeficiency virus (HIV), is a member of the immunoglobulin (Ig) gene superfamily. It contains four extracellular sequences homologous to Ig V_L, domains. The first of these (V_1) is sufficient for bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145bbe9e9b0eadf07425d421ce858ffd
https://doi.org/10.1021/bi00494a019
https://doi.org/10.1021/bi00494a019
Autor:
Richard P. Junghans, Scot A. Marsters, Dezhen Zhang, Avi Ashkenazi, Randal A. Byrn, Steven M. Chamow, Shilpa M. Mhatre, Xiang Y. Tan, David H. Peers
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(9)
We have developed a humanized, bispecific immunoadhesin-antibody (BsIAb) that targets and kills HIV-infected cells. Comprised of CD4-IgG and humanized anti-CD3-IgG, this BsIAb is bifunctional. First, in targeting, it exploits the natural affinity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9c41797e357d7aefa29be0b2ac8e8d
https://pubmed.ncbi.nlm.nih.gov/7930627
https://pubmed.ncbi.nlm.nih.gov/7930627