Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David H. Manz"'
Publikováno v:
Oncotarget
Iron-responsive element-binding proteins (IRPs) are master regulators of cellular iron homeostasis. Our previous work demonstrated that iron homeostasis is altered in prostate cancer and contributes to prostate cancer progression. Here we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c342f603714f9e8648827399aaf4e5e
https://doi.org/10.18632/oncotarget.19288
https://doi.org/10.18632/oncotarget.19288
Publikováno v:
Expert Review of Hematology. 10:65-79
Mitochondria are cellular organelles that perform numerous bioenergetic, biosynthetic, and regulatory functions and play a central role in iron metabolism. Extracellular iron is taken up by cells and transported to the mitochondria, where it is utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c663aeebb82cb539d25dd68d81f177
https://doi.org/10.1080/17474086.2016.1268047
https://doi.org/10.1080/17474086.2016.1268047
Publikováno v:
Annals of the New York Academy of Sciences. 1368:149-161
Iron is an essential dietary element. However, the ability of iron to cycle between oxidized and reduced forms also renders it capable of contributing to free radical formation, which can have deleterious effects, including promutagenic effects that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5a2d69703c8f8feec19b217b3c2e2e
https://doi.org/10.1111/nyas.13008
https://doi.org/10.1111/nyas.13008
Publikováno v:
Annu Rev Nutr
This review explores the multifaceted role that iron has in cancer biology. Epidemiological studies have demonstrated an association between excess iron and increased cancer incidence and risk, while experimental studies have implicated iron in cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7833584a346058af16a5ba76b56af7d3
https://pubmed.ncbi.nlm.nih.gov/30130469
https://pubmed.ncbi.nlm.nih.gov/30130469
Publikováno v:
Expert Review of Hematology. 9:169-186
The secreted peptide hormone hepcidin regulates systemic and local iron homeostasis through degradation of the iron exporter ferroportin. Dysregulation of hepcidin leads to altered iron homeostasis and development of pathological disorders including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab39438261c4fb437e138a505302e257
https://doi.org/10.1586/17474086.2016.1124757
https://doi.org/10.1586/17474086.2016.1124757
Publikováno v:
Antioxidantsredox signaling. 30(8)
Aims: Ferroportin (FPN) is an iron exporter that plays an important role in cellular and systemic iron metabolism. Our previous work has demonstrated that FPN is decreased in prostate tumors. We sought to identify the molecular pathways regulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7a2602714cdbd8791ac126be59062a
https://pubmed.ncbi.nlm.nih.gov/29061069
https://pubmed.ncbi.nlm.nih.gov/29061069
Autor:
Frank M. Torti, Suzy V. Torti, Zhiyong Deng, David J. Lemler, Xiaohong Wang, Bibbin T. Paul, Miranda L. Lynch, Poornima Hegde, David H. Manz, Lia Tesfay
Publikováno v:
Breast Cancer Research : BCR
Background Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum. DCYTB is also a member of a 16-gene iron regulatory gene signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb359e836b4feb6855db6ba332778ec9
https://doi.org/10.1186/s13058-017-0814-9
https://doi.org/10.1186/s13058-017-0814-9
Publikováno v:
The Journal of Neuroscience. 32:6947-6956
Through adulthood, the rodent subventricular zone (SVZ) stem cell niche generates new olfactory bulb interneurons. We had previously reported that the number of new neurons produced in the SVZ declines through aging; however, age-related changes attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9a8cd5364d57259c958b3796060c172
https://doi.org/10.1523/jneurosci.5987-11.2012
https://doi.org/10.1523/jneurosci.5987-11.2012
Autor:
David H. Manz
Publikováno v:
Opflow. 37:18-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86b7c5bdcd30fb49a3ca3d59d529e31
https://doi.org/10.1002/j.1551-8701.2011.tb03104.x
https://doi.org/10.1002/j.1551-8701.2011.tb03104.x
Publikováno v:
Annals of the New York Academy of Sciences. 1368(1)
Iron is an essential dietary element. However, the ability of iron to cycle between oxidized and reduced forms also renders it capable of contributing to free radical formation, which can have deleterious effects, including promutagenic effects that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de0f7c5aed86e125cb8f956b065c9d90
https://pubmed.ncbi.nlm.nih.gov/26890363
https://pubmed.ncbi.nlm.nih.gov/26890363