Zobrazeno 1 - 10
of 156
pro vyhledávání: '"David H. Kirn"'
Autor:
Donald M. McDonald, Caroline J. Breitbach, Naomi De Silva, John C. Bell, David H. Kirn, Marie-Claude Bourgeois-Daigneault, Howard Cha, Jiahu Wang, Corry E. McDonald, Aishwarya Subramanian, Alexander Bell, Brian J. Schriver, Patrizia Murer, Barbara Sennino, Maximilian Nitschké, Minah Kim
Oncolytic viruses pose many questions in their use in cancer therapy. In this study, we assessed the potential of mpJX-594 (mouse-prototype JX-594), a replication-competent vaccinia virus administered by intravenous injection, to target the tumor vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63917aa18323b398d97ece32e06e8aa
https://doi.org/10.1158/0008-5472.c.6509958
https://doi.org/10.1158/0008-5472.c.6509958
Autor:
Donald M. McDonald, Caroline J. Breitbach, Naomi De Silva, John C. Bell, David H. Kirn, Marie-Claude Bourgeois-Daigneault, Howard Cha, Jiahu Wang, Corry E. McDonald, Aishwarya Subramanian, Alexander Bell, Brian J. Schriver, Patrizia Murer, Barbara Sennino, Maximilian Nitschké, Minah Kim
Methods for immunohistochemistry, sectioning, and flow cytometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527441c2cfe5c0f9c861800660d57f75
https://doi.org/10.1158/0008-5472.22417830
https://doi.org/10.1158/0008-5472.22417830
Autor:
Donald M. McDonald, Caroline J. Breitbach, Naomi De Silva, John C. Bell, David H. Kirn, Marie-Claude Bourgeois-Daigneault, Howard Cha, Jiahu Wang, Corry E. McDonald, Aishwarya Subramanian, Alexander Bell, Brian J. Schriver, Patrizia Murer, Barbara Sennino, Maximilian Nitschké, Minah Kim
Figure S1. Structures of mpJX-594 vaccinia virus variants Figure S2. mpJX-594 uptake from vasculature and viral replication Figure S3. Transient mpJX-594 presence in spleen and liver Figure S4. mpJX-594 effects on vascular leakage Figure S5. Antitumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ea3457b240c9770aa0dab9657112b5
https://doi.org/10.1158/0008-5472.22417833
https://doi.org/10.1158/0008-5472.22417833
Autor:
David H. Kirn, John C. Bell, J. Andrea McCart, Christina Addison, Fernando A. Angarita, Hannah Chen, Mong Cho, Jeong Heo, Tae-Ho Hwang, James Burke, Carolina Ilkow, Anne Moon, Manijeh Daneshmand, Richard Patt, Steve H. Thorne, Naomi De Silva, Rozanne Arulanandam, Caroline J. Breitbach
Supplementary Video 1 MPG file - 708K, 3-dimensional tumor model of 10 cm HCC tumor depicted in Fig. 4a (baseline; prior to JX-594 treatment). Beige = perfused; green = hypoperfused; red = necrotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf5606107171f57f15cfe119441f3cf
https://doi.org/10.1158/0008-5472.22398998
https://doi.org/10.1158/0008-5472.22398998
Autor:
David H. Kirn, John C. Bell, J. Andrea McCart, Christina Addison, Fernando A. Angarita, Hannah Chen, Mong Cho, Jeong Heo, Tae-Ho Hwang, James Burke, Carolina Ilkow, Anne Moon, Manijeh Daneshmand, Richard Patt, Steve H. Thorne, Naomi De Silva, Rozanne Arulanandam, Caroline J. Breitbach
Supplementary Video 2 MPG file - 1158K, 3-dimensional tumor model of 10 cm HCC tumor depicted in Fig. 4b (baseline; 5 days post JX-594 treatment). Beige = perfused; green = hypoperfused; red = necrotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b340819ddcf122be950b5c642153296
https://doi.org/10.1158/0008-5472.22398995
https://doi.org/10.1158/0008-5472.22398995
Supplementary Figure 4 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans
Autor:
David H. Kirn, John C. Bell, J. Andrea McCart, Christina Addison, Fernando A. Angarita, Hannah Chen, Mong Cho, Jeong Heo, Tae-Ho Hwang, James Burke, Carolina Ilkow, Anne Moon, Manijeh Daneshmand, Richard Patt, Steve H. Thorne, Naomi De Silva, Rozanne Arulanandam, Caroline J. Breitbach
Supplementary Figure 4 PDF file - 69K, Day 5 enhancement waterfall plot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0773e0ef665ef3b1dbaf2cc5bca4a121
https://doi.org/10.1158/0008-5472.22399007
https://doi.org/10.1158/0008-5472.22399007
Supplementary Figure 3 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans
Autor:
David H. Kirn, John C. Bell, J. Andrea McCart, Christina Addison, Fernando A. Angarita, Hannah Chen, Mong Cho, Jeong Heo, Tae-Ho Hwang, James Burke, Carolina Ilkow, Anne Moon, Manijeh Daneshmand, Richard Patt, Steve H. Thorne, Naomi De Silva, Rozanne Arulanandam, Caroline J. Breitbach
Supplementary Figure 3 PDF file - 83K, Normal fibroblasts (GM38 cells) do not express VEGFR2 and are not sensitized to JX-594 infection upon incubation with VEGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6430c8697b2ea735847288099c883eaf
https://doi.org/10.1158/0008-5472.22399010.v1
https://doi.org/10.1158/0008-5472.22399010.v1
Autor:
Rebecca A. Auer, Andrew P. Makrigiannis, John C. Bell, David H. Kirn, Theresa J. Falls, Caroline J. Breitbach, Tiffany Lam, Abhirami A. Ananth, Julia L. Rintoul, Jiqing Zhang, Almohanad A. Alkayyal, Lundi Ly, Simon Bélanger, Christiano Tanese de Souza, Lee-Hwa Tai
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048663966903e625cb066c6156066c5b
https://doi.org/10.1158/0008-5472.22396367
https://doi.org/10.1158/0008-5472.22396367
Supplementary Figure 1 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans
Autor:
David H. Kirn, John C. Bell, J. Andrea McCart, Christina Addison, Fernando A. Angarita, Hannah Chen, Mong Cho, Jeong Heo, Tae-Ho Hwang, James Burke, Carolina Ilkow, Anne Moon, Manijeh Daneshmand, Richard Patt, Steve H. Thorne, Naomi De Silva, Rozanne Arulanandam, Caroline J. Breitbach
Supplementary Figure 1 PDF file - 74K, VEGF- and FGF-2 stimulate vaccinia replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a9b481f335bd478219e0eccf01ba36
https://doi.org/10.1158/0008-5472.22399016
https://doi.org/10.1158/0008-5472.22399016
Autor:
David H. Kirn, John C. Bell, J. Andrea McCart, Christina Addison, Fernando A. Angarita, Hannah Chen, Mong Cho, Jeong Heo, Tae-Ho Hwang, James Burke, Carolina Ilkow, Anne Moon, Manijeh Daneshmand, Richard Patt, Steve H. Thorne, Naomi De Silva, Rozanne Arulanandam, Caroline J. Breitbach
Supplementary Methods PDF file - 44K, GLP toxicology study, In vivo imaging and mouse immunohistochemical analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8057985ee85df884e076645e4c98127c
https://doi.org/10.1158/0008-5472.22399004
https://doi.org/10.1158/0008-5472.22399004