Zobrazeno 1 - 10
of 30
pro vyhledávání: '"David H. Huffman"'
Autor:
David H. Huffman, Jerold S. Harmatz, Richard I. Shader, Marcia Divoll Allen, Dean S. MacLaughlin, David J. Greenblatt
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 7(2)
Six healthy volunteers participated in single- and multiple-dose pharmacokinetic studies of oral lorazepam. Following single 4-mg oral doses, peak plasma lorazepam concentrations ranging from 40 to 70 ng/ml were reached within 3 hr of the dose. Value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c43123de49baaee375a45d1a5b250e
https://pubmed.ncbi.nlm.nih.gov/20218012
https://pubmed.ncbi.nlm.nih.gov/20218012
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 14:475-478
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4c35eed38d67a9b01c9daafdedf5a9c
https://doi.org/10.1002/jlcr.2580140323
https://doi.org/10.1002/jlcr.2580140323
Publikováno v:
American Heart Journal. 91:28-34
The cardiac glycosides are among the most effective drugs available for improving myocardial contractility. Their use, however, is not without hazard since a significant number of patients develop toxicity. 1, ~ Recent improvements in our knowledge o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0327c6fa795835d29979cc583921a9fe
https://doi.org/10.1016/s0002-8703(76)80431-0
https://doi.org/10.1016/s0002-8703(76)80431-0
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 17:185-190
A simple two step synthetic procedure has been developed for the preparation of deuterated lidocaine. The deuterium was incorporated into the 6′-methyl group which is a metabolically stable position. The overall yield of the synthetic procedure was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cbcf23f1c95e1e3157724212b065cdb
https://doi.org/10.1002/jlcr.2580170205
https://doi.org/10.1002/jlcr.2580170205
Publikováno v:
Journal of Pharmaceutical Sciences. 66:644-647
A new oral digoxin formulation, a digoxin-hydroquinone complex (99% dissolution at 5 min), was evaluated in 12 healthy human volunteers with reference to bioavailability and extent and time of peak serum digoxin levels. This preparation was compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a095ba87135022bd9154359d0bde6508
https://doi.org/10.1002/jps.2600660510
https://doi.org/10.1002/jps.2600660510
Publikováno v:
Clinical Pharmacology & Therapeutics. 16:310-317
Digoxin bioavailability was studied in 6 normal volunteers during chronic dosing. The absorption of digoxin was estimated by: (1) steady-state serum dtgoxin levels; (2) the area IInder the serllm concentration-time curve (AUC) du ring a dosittg inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbdadb3dde20e4137cbf6cca376118f2
https://doi.org/10.1002/cpt1974162310
https://doi.org/10.1002/cpt1974162310
Publikováno v:
Journal of Pharmaceutical Sciences. 64:433-437
The absorption of oral digoxin preparations was evaluated following single-dose administration of 0.5 mg of digoxin to 16 normal volunteers in a randomized crossover design. Absorption was estimated using the cumulative excretion of digoxin in urine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c4b3a3f20a6209065799686b2c26d7
https://doi.org/10.1002/jps.2600640317
https://doi.org/10.1002/jps.2600640317
Autor:
David H. Huffman
Publikováno v:
American Journal of Health-System Pharmacy. 33:179-185
The pharmacology of digitalis compounds is reviewed, and the clinical use of the cardiac glycosides is discussed with particular attention to the selection of patients for digitalis therapy and to a study of the usefulness of various methods to monit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c3bbfd3b9685dcdd8d4e35a7b299ac5
https://doi.org/10.1093/ajhp/33.2.179
https://doi.org/10.1093/ajhp/33.2.179
Autor:
David H. Huffman, Daniel L. Azarnoff
Publikováno v:
Annual Review of Pharmacology and Toxicology. 16:53-66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4ac7e2a7f8b7c559a00e0d193d5a19
https://doi.org/10.1146/annurev.pa.16.040176.000413
https://doi.org/10.1146/annurev.pa.16.040176.000413
Publikováno v:
Clinical Pharmacology & Therapeutics. 19:807-812
The effect of halofenate on beta adrenergic blockade by propranolol was studied in 4 subjects during chronic drug administration in a randomized, double-blind study. The plasma propranolol concentration was significantly lower during treatment with h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26169b6cf2465c532ddca32a3edd5ce9
https://doi.org/10.1002/cpt1976196807
https://doi.org/10.1002/cpt1976196807