Zobrazeno 1 - 10
of 36
pro vyhledávání: '"David H. Heeley"'
Publikováno v:
Biochemistry. 59:4725-4734
The phosphorylated and unphosphorylated forms of tropomyosin Tpm1.1(α) are prepared from adult rabbit heart and compared biochemically. Electrophoresis confirms the high level of enrichment of the chromatography fractions and is consistent with a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ab7d8ac38d81674809f676a398dfbe
https://doi.org/10.1021/acs.biochem.0c00882
https://doi.org/10.1021/acs.biochem.0c00882
Publikováno v:
Biochemistry. 59:2859-2869
The Atlantic salmon Salmo salar survives below 10 °C. The main skeletal muscle is composed of a single isoform of tropomyosin (classified as Tpm1 α-fast) that is >92% identical to the mammalian homologue. How salmon Tpm1 maintains flexibility is in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ab813feb22c45d64217f2bbebbcb45
https://doi.org/10.1021/acs.biochem.0c00416
https://doi.org/10.1021/acs.biochem.0c00416
Publikováno v:
Comparative biochemistry and physiology. Part B, Biochemistrymolecular biology. 254
1) Teleosts such as Atlantic salmon Salmo salar and Atlantic herring Clupea harengus, in contrast to other vertebrates such as mammals, synthesize two contextually very different skeletal muscle actins. Each isoform has been studied at the protein le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928dbe5c93d80cf985f0af0d2c4f6643
https://pubmed.ncbi.nlm.nih.gov/33545366
https://pubmed.ncbi.nlm.nih.gov/33545366
Publikováno v:
Biophysical Journal. 120:341a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5400785d44e8a89938b8ee4a532e0ac7
https://doi.org/10.1016/j.bpj.2020.11.2129
https://doi.org/10.1016/j.bpj.2020.11.2129
Publikováno v:
The Journal of General Physiology
The authors examine the apparent discrepancies from studies aimed at understanding the mechanism of thin filament regulation.
Striated muscle contraction occurs when myosin undergoes a lever-type structural change. This process (the power stroke
Striated muscle contraction occurs when myosin undergoes a lever-type structural change. This process (the power stroke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b80c65895c641a90d16cd05102e2129
https://pubmed.ncbi.nlm.nih.gov/30824574
https://pubmed.ncbi.nlm.nih.gov/30824574
Autor:
Korrina R Fudge, David H. Heeley
Publikováno v:
Biochemistry. 54:2769-2776
Atlantic salmon fast skeletal muscle is composed of an α-type tropomyosin that shares 20 substitutions with a mammalian homologue. Prominent isomorphisms considered to be potentially destabilizing include threonine 179 (core, Ala in rabbit) and a un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9141e9f3f5051ab2930e31608e5ba4de
https://doi.org/10.1021/acs.biochem.5b00156
https://doi.org/10.1021/acs.biochem.5b00156
Autor:
Betty Belknap, Gunnar F. Schröder, Howard D. White, Jamie Eisner, David H. Heeley, Cristina Risi, Vitold E. Galkin
Muscle contraction relies on the interaction of myosin motors with F-actin, which is regulated through a translocation of tropomyosin by the troponin complex in response to Ca2+. The current model of muscle regulation holds that at relaxing (low-Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61a7cef9103bf9121c09e04e3f8944e
https://europepmc.org/articles/PMC5495243/
https://europepmc.org/articles/PMC5495243/
Autor:
David H. Heeley
Publikováno v:
Journal of Muscle Research and Cell Motility. 34:233-237
An historical perspective of the phosphorylation of tropomyosin is provided. The effects of this covalent modification on the properties of striated muscle tropomyosin are summarised. Technical hurdles and findings in other systems are also discussed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722a1f249c9d7bedf969ee50ebdd8360
https://doi.org/10.1007/s10974-013-9351-z
https://doi.org/10.1007/s10974-013-9351-z
Publikováno v:
Biochemistry. 55(9)
Tpm1.1 (α) and Tpm2.2 (β) tropomyosins (39 amino acid substitutions) were isolated from adult rabbit skeletal muscle without chemical modification of cysteine, with negligible phosphorylation as assessed by two-dimensional polyacrylamide gel electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc591cd2e40b47ba79a3dd0c958ce61
https://pubmed.ncbi.nlm.nih.gov/26863527
https://pubmed.ncbi.nlm.nih.gov/26863527
Autor:
Vitold E. Galkin, Betty Belknap, Howard D. White, Gunnar F. Schröder, Cristina Risi, David H. Heeley
Publikováno v:
Biophysical Journal. 114:138a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec5eefcaf148dd6a31b0c374a70a2bd1
https://doi.org/10.1016/j.bpj.2017.11.780
https://doi.org/10.1016/j.bpj.2017.11.780