Zobrazeno 1 - 10
of 491
pro vyhledávání: '"David H. Hall"'
Autor:
Hyunsoo Yim, Daniel T. Choe, J. Alexander Bae, Myung-kyu Choi, Hae-Mook Kang, Ken C. Q. Nguyen, Soungyub Ahn, Sang-kyu Bahn, Heeseung Yang, David H. Hall, Jinseop S. Kim, Junho Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with dist
Externí odkaz:
https://doaj.org/article/4fb911b1c29c4b9683999d212272c371
Autor:
Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J. Guasp, Ken C. Q. Nguyen, Ge Bai, David H. Hall, Barth D. Grant, Monica Driscoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Toxic protein aggregates can spread among neurons to promote human neurodegenerative disease pathology. We found that in C. elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are
Externí odkaz:
https://doaj.org/article/7789921720d54283b486c645e8eba774
Autor:
Muntasir Kamal, Houtan Moshiri, Lilia Magomedova, Duhyun Han, Ken C. Q. Nguyen, May Yeo, Jessica Knox, Rachel Bagg, Amy M. Won, Karolina Szlapa, Christopher M. Yip, Carolyn L. Cummins, David H. Hall, Peter J. Roy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The C. elegans nematode worm is a filter-feeder and requires dietary sources of cholesterol. Here, the authors show that the C. elegans pharynx works as a filter to scavenge hydrophobic small molecules from its surrounding liquid environment.
Externí odkaz:
https://doaj.org/article/01ca567f548348c9ac82fe0b636300c0
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Membrane fusion and fission events at exoplasmic membrane surfaces are not well understood. Here the authors show that the C. elegans cell–cell fusogen AFF-1 is required for endocytic scission and apically-directed membrane trafficking during the d
Externí odkaz:
https://doaj.org/article/921eae60eb714bf09a1d1df17930155c
Caenorhabditis elegans DBL-1/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 1, Pp 343-351 (2018)
Metabolic homeostasis is coordinately controlled by diverse inputs. Understanding these regulatory networks is vital to combating metabolic disorders. The nematode Caenorhabditis elegans has emerged as a powerful, genetically tractable model system f
Externí odkaz:
https://doaj.org/article/ba7ca598260646c681bf3c64454317a0
Autor:
Theadora Tolkin, Ariz Mohammad, Todd A Starich, Ken CQ Nguyen, David H Hall, Tim Schedl, E Jane Albert Hubbard, David Greenstein
Publikováno v:
eLife, Vol 11 (2022)
Gap-junctional signaling mediates myriad cellular interactions in metazoans. Yet, how gap junctions control the positioning of cells in organs is not well understood. Innexins compose gap junctions in invertebrates and affect organ architecture. Here
Externí odkaz:
https://doaj.org/article/e4b672b70b254265898eb86f356a00d5
Autor:
Sophie S Katz, Trevor J Barker, Hannah M Maul-Newby, Alessandro P Sparacio, Ken C Q Nguyen, Chloe L Maybrun, Alexandra Belfi, Jennifer D Cohen, David H Hall, Meera V Sundaram, Alison R Frand
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010348 (2022)
Epithelial cells secrete apical extracellular matrices to form protruding structures such as denticles, ridges, scales, or teeth. The mechanisms that shape these structures remain poorly understood. Here, we show how the actin cytoskeleton and a prov
Externí odkaz:
https://doaj.org/article/a013b578641448c7af122004be999db9
Autor:
Devyn Oliver, Shankar Ramachandran, Alison Philbrook, Christopher M Lambert, Ken C Q Nguyen, David H Hall, Michael M Francis
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1010016 (2022)
The functional properties of neural circuits are defined by the patterns of synaptic connections between their partnering neurons, but the mechanisms that stabilize circuit connectivity are poorly understood. We systemically examined this question at
Externí odkaz:
https://doaj.org/article/1e2825cd57174bc1afbb64da02697e42
Autor:
Emily G Berghoff, Lori Glenwinkel, Abhishek Bhattacharya, HaoSheng Sun, Erdem Varol, Nicki Mohammadi, Amelia Antone, Yi Feng, Ken Nguyen, Steven J Cook, Jordan F Wood, Neda Masoudi, Cyril C Cros, Yasmin H Ramadan, Denise M Ferkey, David H Hall, Oliver Hobert
Publikováno v:
eLife, Vol 10 (2021)
Many neuronal identity regulators are expressed in distinct populations of cells in the nervous system, but their function is often analyzed only in specific isolated cellular contexts, thereby potentially leaving overarching themes in gene function
Externí odkaz:
https://doaj.org/article/e7ee36d6cc2944a39f18085f7d66c34d
Autor:
Madhuja Samaddar, Jérôme Goudeau, Melissa Sanchez, David H Hall, K Adam Bohnert, Maria Ingaramo, Cynthia Kenyon
Publikováno v:
eLife, Vol 10 (2021)
Somatic cells age and die, but the germ-cell lineage is immortal. In Caenorhabditis elegans, germline immortality involves proteostasis renewal at the beginning of each new generation, when oocyte maturation signals from sperm trigger the clearance o
Externí odkaz:
https://doaj.org/article/fc5f2a8480a34f0d98baf157cabd6769