Zobrazeno 1 - 10
of 737
pro vyhledávání: '"David H. Hall"'
Autor:
Guoqiang Wang, Ryan J Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll
Publikováno v:
eLife, Vol 13 (2024)
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles, such as e
Externí odkaz:
https://doaj.org/article/c7cece9d67354cd59c1a7a7f1b5a4181
Autor:
Hyunsoo Yim, Daniel T. Choe, J. Alexander Bae, Myung-kyu Choi, Hae-Mook Kang, Ken C. Q. Nguyen, Soungyub Ahn, Sang-kyu Bahn, Heeseung Yang, David H. Hall, Jinseop S. Kim, Junho Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with dist
Externí odkaz:
https://doaj.org/article/4fb911b1c29c4b9683999d212272c371
Autor:
Fitch, David H. A.
Publikováno v:
The Quarterly Review of Biology, 2008 Dec . 83(4), 402-402.
Externí odkaz:
https://www.jstor.org/stable/10.1086/596247
Autor:
Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J. Guasp, Ken C. Q. Nguyen, Ge Bai, David H. Hall, Barth D. Grant, Monica Driscoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Toxic protein aggregates can spread among neurons to promote human neurodegenerative disease pathology. We found that in C. elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are
Externí odkaz:
https://doaj.org/article/7789921720d54283b486c645e8eba774
Autor:
Muntasir Kamal, Levon Tokmakjian, Jessica Knox, Duhyun Han, Houtan Moshiri, Lilia Magomedova, Ken Cq Nguyen, Hong Zheng, Andrew R Burns, Brittany Cooke, Jessica Lacoste, May Yeo, David H Hall, Carolyn L Cummins, Peter J Roy
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011008 (2023)
The cuticles of ecdysozoan animals are barriers to material loss and xenobiotic insult. Key to this barrier is lipid content, the establishment of which is poorly understood. Here, we show that the p-glycoprotein PGP-14 functions coincidently with th
Externí odkaz:
https://doaj.org/article/5c781b6011f44da6a17ddfaf9152fdfb
Autor:
Yu Wang, Meghan Lee Arnold, Anna Joelle Smart, Guoqiang Wang, Rebecca J Androwski, Andres Morera, Ken CQ Nguyen, Peter J Schweinsberg, Ge Bai, Jason Cooper, David H Hall, Monica Driscoll, Barth D Grant
Publikováno v:
eLife, Vol 12 (2023)
Caenorhabditis elegans neurons under stress can produce giant vesicles, several microns in diameter, called exophers. Current models suggest that exophers are neuroprotective, providing a mechanism for stressed neurons to eject toxic protein aggregat
Externí odkaz:
https://doaj.org/article/f03cd4354e174bee8cd967a06a26154e
Autor:
Dina Aggad, Nicolas Brouilly, Shizue Omi, Clara Luise Essmann, Benoit Dehapiot, Cathy Savage-Dunn, Fabrice Richard, Chantal Cazevieille, Kristin A Politi, David H Hall, Remy Pujol, Nathalie Pujol
Publikováno v:
eLife, Vol 12 (2023)
Apical extracellular matrices (aECMs) form a physical barrier to the environment. In Caenorhabditis elegans, the epidermal aECM, the cuticle, is composed mainly of different types of collagen, associated in circumferential ridges separated by furrows
Externí odkaz:
https://doaj.org/article/a7134827d7264e8e9ea30ed153f4d257
Autor:
Theadora Tolkin, Ariz Mohammad, Todd A Starich, Ken CQ Nguyen, David H Hall, Tim Schedl, E Jane Albert Hubbard, David Greenstein
Publikováno v:
eLife, Vol 11 (2022)
Gap-junctional signaling mediates myriad cellular interactions in metazoans. Yet, how gap junctions control the positioning of cells in organs is not well understood. Innexins compose gap junctions in invertebrates and affect organ architecture. Here
Externí odkaz:
https://doaj.org/article/e4b672b70b254265898eb86f356a00d5
Autor:
Sophie S Katz, Trevor J Barker, Hannah M Maul-Newby, Alessandro P Sparacio, Ken C Q Nguyen, Chloe L Maybrun, Alexandra Belfi, Jennifer D Cohen, David H Hall, Meera V Sundaram, Alison R Frand
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010348 (2022)
Epithelial cells secrete apical extracellular matrices to form protruding structures such as denticles, ridges, scales, or teeth. The mechanisms that shape these structures remain poorly understood. Here, we show how the actin cytoskeleton and a prov
Externí odkaz:
https://doaj.org/article/a013b578641448c7af122004be999db9
Autor:
Devyn Oliver, Shankar Ramachandran, Alison Philbrook, Christopher M Lambert, Ken C Q Nguyen, David H Hall, Michael M Francis
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010291 (2022)
[This corrects the article DOI: 10.1371/journal.pgen.1010016.].
Externí odkaz:
https://doaj.org/article/4f25e4f983ca4959ba737493039f3533