Zobrazeno 1 - 10
of 736
pro vyhledávání: '"David H. Gutmann"'
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 3, Pp 812-818 (2024)
Abstract Optic pathway gliomas (OPGs) arising in children with neurofibromatosis type 1 (NF1) can cause retinal ganglion cell (RGC) dysfunction and vision loss, which occurs more frequently in girls. While our previous studies demonstrated that estro
Externí odkaz:
https://doaj.org/article/0655175d4ba64d979dcae5cfa280b066
Autor:
Jit Chatterjee, Joshua P. Koleske, Astoria Chao, Andrew D. Sauerbeck, Ji-Kang Chen, Xuanhe Qi, Megan Ouyang, Lucy G. Boggs, Rujuta Idate, Lara Isabel Marco Y Marquez, Terrence T. Kummer, David H. Gutmann
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Tissue injury and tumorigenesis share many cellular and molecular features, including immune cell (T cells, monocytes) infiltration and inflammatory factor (cytokines, chemokines) elaboration. Their common pathobiology raises the intriguing
Externí odkaz:
https://doaj.org/article/e13718c6e74748998e03e14aae30335c
Autor:
Frank B. Furnari, Corina Anastasaki, Shan Bian, Howard A. Fine, Tomoyuki Koga, Lu Q. Le, Fausto J. Rodriguez, David H. Gutmann
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/ce1de40fcd154f57adc3a04a5aab3822
Autor:
Leonard D. Kuhrt, Edyta Motta, Nirmeen Elmadany, Hannah Weidling, Raphaela Fritsche-Guenther, Ibrahim E. Efe, Olivia Cobb, Jit Chatterjee, Lucy G. Boggs, Marina Schnauß, Sebastian Diecke, Marcus Semtner, Corina Anastasaki, David H. Gutmann, Helmut Kettenmann
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/27ffcc79016247599283cd70ac5c43af
Autor:
David H. Gutmann
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 810-812 (2023)
Externí odkaz:
https://doaj.org/article/189c7b7b837c4e51ae54f31f50a4cd5e
Autor:
Zhihong Chen, Nishant Soni, Gonzalo Pinero, Bruno Giotti, Devon J. Eddins, Katherine E. Lindblad, James L. Ross, Montserrat Puigdelloses Vallcorba, Tanvi Joshi, Angelo Angione, Wes Thomason, Aislinn Keane, Nadejda M. Tsankova, David H. Gutmann, Sergio A. Lira, Amaia Lujambio, Eliver E. B. Ghosn, Alexander M. Tsankov, Dolores Hambardzumyan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Myeloid cells are the predominant cell type in the tumor microenvironment of human and murine glioblastoma (GBM). By generating a mouse model deficient for all monocyte chemoattractant proteins, here the authors show that blocking monocyte recruitmen
Externí odkaz:
https://doaj.org/article/358a75b5c19346a48cc38b1a4dc8779e
Autor:
Francesca Logiacco, Laura Cathleen Grzegorzek, Elizabeth C. Cordell, Oliver Popp, Philipp Mertins, David H. Gutmann, Helmut Kettenmann, Marcus Semtner
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract We previously discovered a sex-by-genotype defect in microglia function using a heterozygous germline knockout mouse model of Neurofibromatosis type 1 (Nf1 ± mice), in which only microglia from male Nf1 ± mice exhibited defects in purinerg
Externí odkaz:
https://doaj.org/article/9d5a9756881946f5958a17392cf3aabf
Autor:
Corina Anastasaki, Jit Chatterjee, Olivia Cobb, Shilpa Sanapala, Suzanne M. Scheaffer, Amanda De Andrade Costa, Anna F. Wilson, Chloe M. Kernan, Ameera H. Zafar, Xia Ge, Joel R. Garbow, Fausto J. Rodriguez, David H. Gutmann
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract A major obstacle to identifying improved treatments for pediatric low-grade brain tumors (gliomas) is the inability to reproducibly generate human xenografts. To surmount this barrier, we leveraged human induced pluripotent stem cell (hiPSC)
Externí odkaz:
https://doaj.org/article/0bce5b7aff7c4c1bb0ec1923cf2a939e
Autor:
Corina Anastasaki, Juan Mo, Ji-Kang Chen, Jit Chatterjee, Yuan Pan, Suzanne M. Scheaffer, Olivia Cobb, Michelle Monje, Lu Q. Le, David H. Gutmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Neuronal activity is emerging as a driver of nervous system tumors. Here, the authors show in mouse models of Neurofibromatosis-1 (NF1) that Nf1 mutations differentially drive both central and peripheral nervous system tumor growth in mice through re
Externí odkaz:
https://doaj.org/article/da669970414141a2a3165032a695c25b
Autor:
Jit Chatterjee, Shilpa Sanapala, Olivia Cobb, Alice Bewley, Andrea K. Goldstein, Elizabeth Cordell, Xia Ge, Joel R. Garbow, Michael J. Holtzman, David H. Gutmann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Clinical studies have suggested a reduced incidence of brain tumors, including optic gliomas, in children with asthma. Here, in a mouse model of Neurofibromatosis type 1 associated low grade optic glioma, the authors show that experimental asthma ind
Externí odkaz:
https://doaj.org/article/e627dfd988e34a69a26d27c59e8d639b