Zobrazeno 1 - 10
of 218
pro vyhledávání: '"David H. Dockrell"'
Autor:
Paul A. De Sousa, Leo Perfect, Jinpei Ye, Kay Samuels, Ewa Piotrowska, Martin Gordon, Ryan Mate, Elsa Abranches, Thomas M. Wishart, David H. Dockrell, Aidan Courtney
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Hyaluronan (HA) is an extracellular glycosaminoglycan polysaccharide with widespread roles throughout development and in healthy and neoplastic tissues. In pluripotent stem cell culture it can support both stem cell renewal and di
Externí odkaz:
https://doaj.org/article/bf13acb1260e4f5080469f86cb5609f0
Autor:
Rohit Bazaz, Helen M. Marriott, Carl Wright, Janet Chamberlain, Laura E. West, Catherine Gelsthorpe, Paul R. Heath, Afsaneh Maleki-Dizaji, Sheila E. Francis, David H. Dockrell
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionDespite epidemiological associations between community acquired pneumonia (CAP) and myocardial infarction, mechanisms that modify cardiovascular disease during CAP are not well defined. In particular, largely due to a lack of relevant exp
Externí odkaz:
https://doaj.org/article/6665aae7966b4665af002be385a30c39
Autor:
Bo Li, Sara M. Clohisey, Bing Shao Chia, Bo Wang, Ang Cui, Thomas Eisenhaure, Lawrence D. Schweitzer, Paul Hoover, Nicholas J. Parkinson, Aharon Nachshon, Nikki Smith, Tim Regan, David Farr, Michael U. Gutmann, Syed Irfan Bukhari, Andrew Law, Maya Sangesland, Irit Gat-Viks, Paul Digard, Shobha Vasudevan, Daniel Lingwood, David H. Dockrell, John G. Doench, J. Kenneth Baillie, Nir Hacohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Here, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of ant
Externí odkaz:
https://doaj.org/article/c1f734a4d6574c6d950eb373c2f18352
Autor:
Joby Cole, Adrienn Angyal, Richard D. Emes, Tim John Mitchell, Mark J. Dickman, David H. Dockrell
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Epigenetic modifications regulate gene expression in the host response to a diverse range of pathogens. The extent and consequences of epigenetic modification during macrophage responses to Streptococcus pneumoniae, and the role of pneumolysin, a key
Externí odkaz:
https://doaj.org/article/fbd48eadf6794e8ca4498eb2aac07aff
Autor:
Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key ro
Externí odkaz:
https://doaj.org/article/69dfb1e9146244cb9d8db5194cef99af
Autor:
Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key ro
Externí odkaz:
https://doaj.org/article/fdf252eb205a4660a9cdfc932717fe99
Autor:
Elizabeth K. Marsh, Elizabeth C. Prestwich, Lynne Williams, Amber R. Hart, Clare F. Muir, Lisa C. Parker, Marnix R. Jonker, Irene H. Heijink, Wim Timens, Mark Fife, Tracy Hussell, Marc B. Hershenson, J. Kelley Bentley, Shao-Cong Sun, Ben S. Barksby, Lee A. Borthwick, James P. Stewart, Ian Sabroe, David H. Dockrell, Helen M. Marriott
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Pellino-1 is an E3 ubiquitin ligase known to regulate virally-induced inflammation. We wished to
Externí odkaz:
https://doaj.org/article/c5942d2d51cf4be9955c03b1925a6bc9
Autor:
Katie Watson, Clark D. Russell, J. Kenneth Baillie, Kev Dhaliwal, J. Ross Fitzgerald, Timothy J. Mitchell, A. John Simpson, Stephen A. Renshaw, David H. Dockrell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Antimicrobial therapy has provided the main component of chemotherapy against bacterial pathogens. The effectiveness of this strategy has, however, been increasingly challenged by the emergence of antimicrobial resistance which now threatens the sust
Externí odkaz:
https://doaj.org/article/4b74a1baa9f640959122998d90973e53
Autor:
Bethany M. Hughes, Charlotte S. Burton, Abigail Reese, Maisha F. Jabeen, Carl Wright, Jessica Willis, Nika Khoshaein, Elizabeth K. Marsh, Peter Peachell, Shao C. Sun, David H. Dockrell, Helen M. Marriott, Ian Sabroe, Alison M. Condliffe, Lynne R. Prince
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Non-typeable Haemophilus influenzae (NTHi) is a frequent cause of lower respiratory tract infection in people with chronic obstructive pulmonary disease (COPD). Pellino proteins are a family of E3 ubiquitin ligases that are critical regulators of TLR
Externí odkaz:
https://doaj.org/article/0a33add6275f446386843c1bf0f878db
Autor:
Martin A. Bewley, Michael Naughton, Julie Preston, Andrea Mitchell, Ashleigh Holmes, Helen M. Marriott, Robert C. Read, Timothy J. Mitchell, Moira K. B. Whyte, David H. Dockrell
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT Intracellular killing of Streptococcus pneumoniae is complemented by induction of macrophage apoptosis. Here, we show that the toxin pneumolysin (PLY) contributes both to lysosomal/phagolysosomal membrane permeabilization (LMP), an upstream
Externí odkaz:
https://doaj.org/article/cd6c0f19f379481bba4b605edcf51faa