Zobrazeno 1 - 10
of 240
pro vyhledávání: '"David H. Thompson"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1154 (2024)
High-risk BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) is a condition that is typically treated with Bacillus Calmette–Guérin (BCG) therapy. Unfortunately, NMIBC is characterized by high recurrence, with a significant percentage of
Externí odkaz:
https://doaj.org/article/1adc78cfb7e241aaaf5e1533e1328fc5
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0285651 (2024)
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a complex multifunctional kinase that is highly expressed in central nervous tissues and plays a key regulatory role in the calcium signaling pathway. Despite over 30 years of recombinant exp
Externí odkaz:
https://doaj.org/article/7cee40b4adb741d7ae522cb3ea5e0c78
Autor:
Robert J. Nicholas, Michael A. McGuire, Seok-Hee Hyun, Madeline N. Cullison, David H. Thompson
Publikováno v:
Frontiers in Chemical Engineering, Vol 4 (2022)
In an effort to strengthen the resiliency of supply chains for active pharmaceutical ingredients (API), continuous manufacturing processes may be optimized with respect to improved chemoselectivity, production rate, yield, and/or process intensity. W
Externí odkaz:
https://doaj.org/article/dfd3fdb93a664897b31d9fddfe983f0d
Autor:
Shayak Samaddar, Debosreeta Bose, Bradley P Loren, Joseph L Skulsky, Olga Ilnytska, Zachary J Struzik, Judith Storch, David H Thompson
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0268613 (2022)
Niemann-Pick Type C is a rare metabolic disorder characterized by the cellular accumulation of cholesterol within endosomal and lysosomal compartments. 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) containing polyrotaxanes represent an attractive approa
Externí odkaz:
https://doaj.org/article/1e7b16d0ab1b47fe9680d21077cdf5bf
Publikováno v:
Molecules, Vol 27, Iss 7, p 2199 (2022)
Naturally occurring phospholipids, such as phosphatidyl glycerol (PG), are gaining interest due to the roles they play in disease mechanisms. To elucidate the metabolism of PG, an optically pure material is required, but this is unfortunately not com
Externí odkaz:
https://doaj.org/article/95909754627540bd886d9bedf2f96647
Publikováno v:
Polymers, Vol 14, Iss 4, p 739 (2022)
Protein adsorption onto nanomaterials is a process of vital significance and it is commonly controlled by functionalizing their surface with polymers. The efficiency of this strategy depends on the design parameters of the nanoconstruct. Although sig
Externí odkaz:
https://doaj.org/article/4b2b4084728547fdb4d4a121fcee04d8
Autor:
Shruti A. Biyani, Corryn Lytle, Seok-Hee Hyun, Michael A. McGuire, Ranya Pendyala, David H. Thompson
Publikováno v:
Organic Process Research & Development. 26:2715-2727
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04881eaaeb5b924c9abfa0a4649794ea
https://doi.org/10.1021/acs.oprd.2c00184
https://doi.org/10.1021/acs.oprd.2c00184
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a complex multifunctional kinase that is highly expressed in central nervous tissues and plays a key regulatory role in the calcium signaling pathway. Despite over 30 years of recombinant exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed87bca16ca1e7f095b3121c34abb69d
https://doi.org/10.1101/2023.04.28.538705
https://doi.org/10.1101/2023.04.28.538705
Supplementary Materials from Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6680a0363b71bf0abb3be6090127adea
https://doi.org/10.1158/1535-7163.22484622
https://doi.org/10.1158/1535-7163.22484622
Arsenic trioxide (As2O3) is a frontline drug for treatment of acute promyelocytic leukemia and is in clinical trials for treatment of other malignancies, including multiple myeloma; however, efforts to expand clinical utility to solid tumors have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dee7aa042c7ec0747e802b92ea16261
https://doi.org/10.1158/1535-7163.c.6531495.v1
https://doi.org/10.1158/1535-7163.c.6531495.v1