Zobrazeno 1 - 10
of 408
pro vyhledávání: '"David H. , Sherman"'
Autor:
Donghui Yan, Muqing Zhou, Abhinav Adduri, Yihao Zhuang, Mustafa Guler, Sitong Liu, Hyonyoung Shin, Torin Kovach, Gloria Oh, Xiao Liu, Yuting Deng, Xiaofeng Wang, Liu Cao, David H. Sherman, Pamela J. Schultz, Roland D. Kersten, Jason A. Clement, Ashootosh Tripathi, Bahar Behsaz, Hosein Mohimani
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Type 1 polyketides are a major class of natural products used as antiviral, antibiotic, antifungal, antiparasitic, immunosuppressive, and antitumor drugs. Analysis of public microbial genomes leads to the discovery of over sixty thousand typ
Externí odkaz:
https://doaj.org/article/2b6d42dae54c43a3a35eb103adacd3a6
Autor:
Woonkee S. Jo, Brian J. Curtis, Mohammad Rehan, Maria L. Adrover-Castellano, David H. Sherman, Alan R. Healy
Publikováno v:
JACS Au, Vol 4, Iss 5, Pp 2058-2066 (2024)
Externí odkaz:
https://doaj.org/article/6da09e24480f446fa84294b10d76cfbf
Autor:
Colleen E. Yancey, Lauren Hart, Sierra Hefferan, Osama G. Mohamed, Sean A. Newmister, Ashootosh Tripathi, David H. Sherman, Gregory J. Dick
Publikováno v:
mSystems, Vol 9, Iss 7 (2024)
ABSTRACT Microcystis spp. are renowned for producing the hepatotoxin microcystin in freshwater cyanobacterial harmful algal blooms around the world, threatening drinking water supplies and public and environmental health. However, Microcystis genomes
Externí odkaz:
https://doaj.org/article/5b73efee23e84b3990a0d2dfb261fac0
Autor:
Edward Kalkreuter, Kyle S. Bingham, Aaron M. Keeler, Andrew N. Lowell, Jennifer J. Schmidt, David H. Sherman, Gavin J. Williams
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Engineering efforts have focused on acyltransferase (AT) domains of modular polyketide synthases (PKSs) to site-selectively modify the resulting polyketides, but critical AT residues involved in substrate selection have not been fully elucidated. Her
Externí odkaz:
https://doaj.org/article/8ac2f471c63242d2830d7699ac214224
Autor:
Zhiwen Liu, Sebastian Rivera, Sean A. Newmister, Jacob N. Sanders, Qiuyue Nie, Shuai Liu, Fanglong Zhao, Joseph D. Ferrara, Hao-Wei Shih, Siddhant Patil, Weijun Xu, Mitchell D. Miller, George N. Phillips, K. N. Houk, David H. Sherman, Xue Gao
Publikováno v:
Nature chemistry, vol 15, iss 4
Nat Chem
Nat Chem
The Diels-Alder cycloaddition is one of the most powerful approaches in organic synthesis and is often used in the synthesis of important pharmaceuticals. Yet, strictly controlling the stereoselectivity of the Diels-Alder reactions is challenging, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ae8a668ab7aa5c190edded534be744
https://doi.org/10.1038/s41557-022-01117-6
https://doi.org/10.1038/s41557-022-01117-6
Autor:
Samantha P. Kelly, Vikram V. Shende, Autumn R. Flynn, Qingyun Dan, Ying Ye, Janet L. Smith, Sachiko Tsukamoto, Matthew S. Sigman, David H. Sherman
Publikováno v:
Journal of the American Chemical Society, vol 144, iss 42
J Am Chem Soc
J Am Chem Soc
Prenyltransfer is an early-stage carbon-hydrogen bond (C-H) functionalization prevalent in the biosynthesis of a diverse array of biologically active bacterial, fungal, plant, and metazoan diketopiperazine (DKP) alkaloids. Toward the development of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36097fe5981e682e8f7d8759cf2c5df3
https://doi.org/10.1021/jacs.2c06631
https://doi.org/10.1021/jacs.2c06631
Autor:
Michael M. Gilbert, Matthew D. DeMars, Song Yang, Jessica M. Grandner, Shoulei Wang, Hengbin Wang, Alison R. H. Narayan, David H. Sherman, K. N. Houk, John Montgomery
Publikováno v:
ACS Central Science, Vol 3, Iss 12, Pp 1304-1310 (2017)
Externí odkaz:
https://doaj.org/article/ee41c939216b4bfebaf6e1642c63545c
Autor:
Sujay Paul, Yvette Ludeña, Gretty K. Villena, Fengan Yu, David H. Sherman, Marcel Gutiérrez-Correa
Publikováno v:
Standards in Genomic Sciences, Vol 12, Iss 1, Pp 1-8 (2017)
Abstract Filamentous fungus Aspergillus niger has high industrial value due to their lignocellulolytic enzyme activities and ATCC 10864 is one of the few type strains of A. niger which has a unique biofilm forming capability. Here we report the first
Externí odkaz:
https://doaj.org/article/32237eb478314210ab5f2f498ba713b4
Autor:
Rosa V. Espinoza, David H. Sherman
Publikováno v:
Synthetic and Systems Biotechnology, Vol 5, Iss 2, Pp 97-98 (2020)
Externí odkaz:
https://doaj.org/article/41e9cfc3931c48178421cb5703637222
Publikováno v:
Applied and Environmental Microbiology. 89
Microcystis spp. dominate cyanobacterial harmful algal blooms (cyanoHABs) worldwide and pose significant threats to water quality through the production of secondary metabolites, many of which are toxic. While the toxicity and biochemistry of microcy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64650630f0ea07e854d2714564a473ab
https://doi.org/10.1128/aem.02092-22
https://doi.org/10.1128/aem.02092-22