Výsledky vyhledávání - "David H Sherr"

Akademický článek

Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.

Autor: Margaret M Lowe, Jeff E Mold, Bittoo Kanwar, Yong Huang, Alexander Louie, Michael P Pollastri, Cuihua Wang, Gautam Patel, Diana G Franks, Jennifer Schlezinger, David H Sherr, Allen E Silverstone, Mark E Hahn, Joseph M McCune

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87877 (2014)

The aryl hydrocarbon receptor (AHR) binds to environmental toxicants including synthetic halogenated aromatic hydrocarbons and is involved in a diverse array of biological processes. Recently, the AHR was shown to control host immunity by affecting t

Externí odkaz: https://doaj.org/article/2aec0a2304d840ffbab45fd32f29823f

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Akademický článek

Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.

Autor: Daniel Gusenleitner, Scott S Auerbach, Tisha Melia, Harold F Gómez, David H Sherr, Stefano Monti

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102579 (2014)

BACKGROUND:Despite an overall decrease in incidence of and mortality from cancer, about 40% of Americans will be diagnosed with the disease in their lifetime, and around 20% will die of it. Current approaches to test carcinogenic chemicals adopt the

Externí odkaz: https://doaj.org/article/844fbd201a39442d9f1ba02cc68aa821

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Akademický článek

The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022

Autor: Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernández-Salguero, Xavier Coumoul, Andrew D. Patterson

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 6, p 5550 (2023)

The aryl hydrocarbon receptor (AHR) is a sensor of low-molecular-weight molecule signals that originate from environmental exposures, the microbiome, and host metabolism. Building upon initial studies examining anthropogenic chemical exposures, the l

Externí odkaz: https://doaj.org/article/51868d43c72e45e9b088150fefa88fb8

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Supplemental Figure 1: Immortalized OSCC cell lines express AHR protein. from Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis

Autor: David H. Sherr, Manish V. Bais, Stefano Monti, Maria Kukuruzinska, Caroline A. Genco, Joseph P. Mizgerd, Petros Koutrakis, Khalid Alamoud, Olga Novikov, Zhongyan Wang, Alejandra Ramirez-Cardenas, Elizabeth A. Stanford

Expression of AHR in whole cell lysates from HSC-3 and Cal27 cells was determined by Western immunoblot analysis, using AhR-specific (1:1000, 13790#, Cell signaling), and β-actin-specific (1:2000, A5441, Sigma-Aldrich) antibodies. Cell lysates from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d35b21c9b15aedeb1cc74449acadbba
https://doi.org/10.1158/1541-7786.22511620.v1

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Data from Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis

Over 45,000 new cases of oral and pharyngeal cancers are diagnosed and account for over 8,000 deaths a year in the United States. An environmental chemical receptor, the aryl hydrocarbon receptor (AhR), has previously been implicated in oral squamous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d81e730bd7216f3e994548a7d782b4c5
https://doi.org/10.1158/1541-7786.c.6539992.v1

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Supplemental Figure 2: Activation of the AHR with a mixture of agonists' results in further increase in SCC2 cell migration. from Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis

A) Representative images of HSC-3 cell migration at 24 hours after cells were cultured to confluence, scratched, and treated with vehicle, 10 μM B(a)P, 1 μM PYO, particulate matter 2.5 um (PM2.5), 10 μM B(a)P and 1 μM PYO, or 10 μM B(a)P and PM2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a67959a860fefe4793e7d720d92214
https://doi.org/10.1158/1541-7786.22511617

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Akademický článek

How the AHR Became Important in Cancer: The Role of Chronically Active AHR in Cancer Aggression

Autor: Zhongyan Wang, Megan Snyder, Jessica E. Kenison, Kangkang Yang, Brian Lara, Emily Lydell, Kawtar Bennani, Olga Novikov, Anthony Federico, Stefano Monti, David H. Sherr

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 1, p 387 (2020)

For decades, the aryl hydrocarbon receptor (AHR) was studied for its role in environmental chemical toxicity i.e., as a quirk of nature and a mediator of unintended consequences of human pollution. During that period, it was not certain that the AHR

Externí odkaz: https://doaj.org/article/4c17215a4f134a73b2bb53a6d58c7cf0

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