Výsledky vyhledávání - "David H Munn"

Akademický článek

Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy

Autor: Gang Zhou, David H Munn, Zhi-Chun Ding, Marco L Davila, Hongyan Xu, Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Gregory Gorman, Roni Bollag, Locke J Bryan, Gary A Piazza

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)

Background Adoptive cell therapy (ACT) using genetically modified T cells has evolved into a promising treatment option for patients with cancer. However, even for the best-studied and clinically validated CD19-targeted chimeric antigen receptor (CAR

Externí odkaz: https://doaj.org/article/a814f619a9934bacafbe74860b95a4f2

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Akademický článek

p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy

Autor: Jennifer L Waller, David H Munn, Chunwan Lu, Kebin Liu, John D Klement, Alyssa D Smith, Dafeng Yang, Darren D Browning

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background NF-κB is a key link between inflammation and cancer. Previous studies of NF-κB have largely focused on tumor cells, and the intrinsic function of NF-κB in T cells in tumor development and response to immunotherapy is largely unknown. We

Externí odkaz: https://doaj.org/article/7eb23d0d53444991931b9e776c11cd0c

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Akademický článek

Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase.

Autor: Lei Huang, Rong Ou, Guilherme Rabelo de Souza, Thiago M Cunha, Henrique Lemos, Eslam Mohamed, Lingqian Li, Gabriela Pacholczyk, Janice Randall, David H Munn, Andrew L Mellor

Publikováno v: PLoS Pathogens, Vol 12, Iss 5, p e1005615 (2016)

Increased pain sensitivity is a comorbidity associated with many clinical diseases, though the underlying causes are poorly understood. Recently, chronic pain hypersensitivity in rodents treated to induce chronic inflammation in peripheral tissues wa

Externí odkaz: https://doaj.org/article/603518df68d54c8c82820f9b6372065e

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Akademický článek

Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment.

Autor: Aicha Jrad-Lamine, Joelle Henry-Berger, Christelle Damon-Soubeyrand, Fabrice Saez, Ayhan Kocer, Laurent Janny, Hanae Pons-Rejraji, David H Munn, Andrew L Mellor, Najoua Gharbi, Rémi Cadet, Rachel Guiton, Robert J Aitken, Joël R Drevet

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66494 (2013)

The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate l

Externí odkaz: https://doaj.org/article/8ab5a029b0a84e7cb1dec43d517f30e3

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Akademický článek

The Simple prEservatioN of Single cElls method for cryopreservation enables the generation of single-cell immune profiles from whole blood

Autor: Sarthak Satpathy, Beena E. Thomas, William J. Pilcher, Mojtaba Bakhtiari, Lori A. Ponder, Rafal Pacholczyk, Sampath Prahalad, Swati S. Bhasin, David H. Munn, Manoj K. Bhasin

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionCurrent multistep methods utilized for preparing and cryopreserving single-cell suspensions from blood samples for single-cell RNA sequencing (scRNA-seq) are time-consuming, requiring trained personnel and special equipment, so limiting t

Externí odkaz: https://doaj.org/article/20be76746b6a40eebb3954e9418e477a

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