Zobrazeno 1 - 10
of 133
pro vyhledávání: '"David H Lovett"'
Autor:
Hye Won Lee, Sun Ju Lee, Min Young Lee, Mi Wha Park, Sang Sik Kim, Nari Shin, David H Lovett, Sun Sik Bae, Jinhee Ahn, Jin-Sup Park, Jun-Hyok Oh, Jung Hyun Choi, Han Cheol Lee, Kwang Soo Cha, Taek Jong Hong, Sang Heon Song
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221798 (2019)
BackgroundDiabetic cardiomyopathy (DM CMP) is defined as cardiomyocyte damage and ventricular dysfunction directly associated with diabetes independent of concomitant coronary artery disease or hypertension. Matrix metalloproteinases (MMPs), especial
Externí odkaz:
https://doaj.org/article/b86f5db1d4074813b3e53516819a3cff
Autor:
Kimberly Spaulding, Kiyoaki Takaba, Alexander Collins, Farshid Faraji, Guanying Wang, Esteban Aguayo, Liang Ge, David Saloner, Arthur W Wallace, Anthony J Baker, David H Lovett, Mark B Ratcliffe
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192720 (2018)
Decreased contractility in the non-ischemic border zone surrounding a MI is in part due to degradation of cardiomyocyte sarcomeric components by intracellular matrix metalloproteinase-2 (MMP-2). We recently reported that MMP-2 levels were increased i
Externí odkaz:
https://doaj.org/article/56f8bd079baf4cbf975c5ead44a216f4
Autor:
Sang Soo Kim, Nari Shin, Sun Sik Bae, Min Young Lee, Harin Rhee, Il Young Kim, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, David H Lovett, Sang Heon Song
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171625 (2017)
BACKGROUND:We recently reported on the enhanced expression of two isoforms of matrix metalloproteinase-2 (MMP-2) in human renal transplantation delayed graft function. These consist of the conventional secreted, full length MMP-2 isoform (FL-MMP-2) a
Externí odkaz:
https://doaj.org/article/03cb7eaf30534e209fadfdd880041137
Autor:
Shaynah Wanga, Carla S Ceron, Cynthia Delgado, Sunil K Joshi, Kimberly Spaulding, Joy P Walker, Sangheon Song, Jean L Olson, David H Lovett
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136276 (2015)
Delayed graft function (DGF) is a frequent complication of renal transplantation, particularly in the setting of transplantation of kidneys derived from deceased donors and expanded-criteria donors. DGF results from tubular epithelial cell injury and
Externí odkaz:
https://doaj.org/article/1febf9444dbc45be9dfa81a744180bd7
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
The full-length isoform of matrixmetalloproteinase-2 (FL-MMP-2) plays a role in turnover of the cardiac extracellular matrix. FL-MMP-2 is also present intracellularly in association with sarcomeres and, in the setting of oxidative stress, cleaves myo
Externí odkaz:
https://doaj.org/article/888d5d56b3ea4ce7a5d4bcf2c32d65fd
Autor:
David H Lovett, Rajeev Mahimkar, Robert L Raffai, Leslie Cape, Bo-Qing Zhu, Zhu-Qiu Jin, Anthony J Baker, Joel S Karliner
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68154 (2013)
Matrix metalloproteinase-2 (MMP-2) is increasingly recognized as a major contributor to progressive cardiac injury within the setting of ischemia-reperfusion injury and ischemic ventricular remodeling. A common feature of these conditions is an incre
Externí odkaz:
https://doaj.org/article/389d7976b2464c7e93cdd5bcec7e1bda
Autor:
David H Lovett, Rajeev Mahimkar, Robert L Raffai, Leslie Cape, Elena Maklashina, Gary Cecchini, Joel S Karliner
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34177 (2012)
Experimental and clinical evidence has pinpointed a critical role for matrix metalloproteinase-2 (MMP-2) in ischemic ventricular remodeling and systolic heart failure. Prior studies have demonstrated that transgenic expression of the full-length, 68
Externí odkaz:
https://doaj.org/article/df28ddd0db0c4fc59120878ac0fa81ad
Autor:
Il Young Kim, Sang Soo Kim, Hye Won Lee, Sun Sik Bae, Hong Koo Ha, Eun Soon Jung, Min Young Lee, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, David H. Lovett, Sang Heon Song
Publikováno v:
BMC Nephrology, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background We recently reported on the enhanced tubular expression of two discrete isoforms of the MMP-2 (full length and N-terminal truncated, FL-MMP-2, NTT-MMP-2) in a murine model and human diabetic kidneys. In the present study, we exami
Externí odkaz:
https://doaj.org/article/cb9e75be883045698e824237140fbacb
Autor:
David H. Lovett, Kirsten Bibbins-Domingo, Vanessa Grubbs, Eric Vittinghoff, Mark I. Ryder, Steven Offenbacher, Faviola Garcia, George W. Taylor, Neil R. Powe, Peter Ganz, Bonnie Jue
Publikováno v:
Kidney Medicine, Vol 2, Iss 1, Pp 49-58 (2020)
Kidney medicine, vol 2, iss 1
Kidney Medicine
Kidney medicine, vol 2, iss 1
Kidney Medicine
Rationale & Objective Observational studies have suggested that periodontal disease may be a modifiable risk factor for chronic kidney disease (CKD). The Kidney and Periodontal Disease (KAPD) Study was designed to determine the feasibility of conduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ec8af9d86e1cfc62a80b3808e67cb7
http://www.sciencedirect.com/science/article/pii/S2590059519301748
http://www.sciencedirect.com/science/article/pii/S2590059519301748
Autor:
Guanying Wang, Philip M. Swigart, Nikitha P. Reddy, Paul C. Simpson, David H. Lovett, Pranavi Dulam, Patrick M. Cowley, Anaha Raghunathan, Anthony J. Baker
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H224-H232
Right ventricular (RV) failure (RVF) is a serious disease with no effective treatment available. We recently reported a disease prevention study showing that chronic stimulation of α1A-adrenergic receptors (α1A-ARs), started at the time of RV injur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90780f932855ceb19b2ca8dc1d1fe351
https://doi.org/10.1152/ajpheart.00507.2018
https://doi.org/10.1152/ajpheart.00507.2018