Zobrazeno 1 - 10
of 85
pro vyhledávání: '"David H Burk"'
Autor:
Sangho Yu, Helia Cheng, Marie François, Emily Qualls-Creekmore, Clara Huesing, Yanlin He, Yanyan Jiang, Hong Gao, Yong Xu, Andrea Zsombok, Andrei V Derbenev, Eduardo A Nillni, David H Burk, Christopher D Morrison, Hans-Rudolf Berthoud, Heike Münzberg
Publikováno v:
eLife, Vol 7 (2018)
The adipokine leptin acts on the brain to regulate energy balance but specific functions in many brain areas remain poorly understood. Among these, the preoptic area (POA) is well known to regulate core body temperature by controlling brown fat therm
Externí odkaz:
https://doaj.org/article/807890a93100424e901e1a29fb71614a
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6940 (2009)
BACKGROUND:Fully differentiated adipocytes are considered to be refractory to introduction of siRNA via lipid-based transfection. However, large scale siRNA-based loss-of-function screening of adipocytes using either electroporation or virally-mediat
Externí odkaz:
https://doaj.org/article/4d939db391be4e44a08d38a254bfa794
Autor:
Jennifer L. Bailey, David H. Burk, Susan J. Burke, Scott D. Reed, Sujoy Ghosh, Carrie M. Elks
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2077 (2022)
Laminins are heterotrimeric glycoproteins with structural and functional roles in basement membranes. The predominant laminin alpha chain found in adipocyte basement membranes is laminin α4 (LAMA4). Global LAMA4 deletion in mice leads to reduced adi
Externí odkaz:
https://doaj.org/article/b1ed2e85be37421d8cf0b9454fd65f2c
Autor:
Samantha L. Martin, Michelle I. Cardel, Tiffany L. Carson, James O. Hill, Takara Stanley, Steven Grinspoon, Felicia Steger, Loneke T. Blackman Carr, Maxine Ashby-Thompson, Delisha Stewart, Jamy Ard, Fatima Cody Stanford, Raziel Rojas-Rodriguez, Mabel Toribio, Gabrielle Page-Wilson, Ursula White, Glenn Rowe, Marine Saint-Cyr, Rita Brookheart, Lauren Adele Fowler, Gwen Twillman, Felicia Price, April Stull, Sonia Vega-Lopez, Tony Comuzzie, Catherine M. Kotz, Francoise Knox Kazimierczuk, Monica L. Baskin, Robert Newton, Andrew Greenberg, Camile E. Powe, Dympna Gallagher, David H. Burk, Elissa S. Epel, Paul S. MacLean, Kimberly P. Truesdale, Dominic N. Reeds, Ellen A. Schur, Nicole P. Redmond, Minor L. Cushion
Publikováno v:
The American Journal of Clinical Nutrition. 117:659-671
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35bdf71bd2f8830d0ac9b3b1ccc64b79
https://doi.org/10.1016/j.ajcnut.2023.02.001
https://doi.org/10.1016/j.ajcnut.2023.02.001
Autor:
J. Jason Collier, Heidi M. Batdorf, Thomas M. Martin, Kristen E. Rohli, David H. Burk, Danhong Lu, Chris R. Cooley, Michael D. Karlstad, Joseph W. Jackson, Tim E. Sparer, Jingying Zhang, Randall L. Mynatt, Susan J. Burke
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101140- (2021)
Objective: The expression of the interleukin-1 receptor type I (IL-1R) is enriched in pancreatic islet β-cells, signifying that ligands activating this pathway are important for the health and function of the insulin-secreting cell. Using isolated m
Externí odkaz:
https://doaj.org/article/1a3edd9950484f2c84401d8bd197de64
Autor:
J. Jason Collier, Heidi M. Batdorf, Kaelan L. Merrifield, Thomas M. Martin, Ursula White, Eric Ravussin, David H. Burk, Chris R. Cooley, Michael D. Karlstad, Susan J. Burke
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1189 (2021)
Obesity, insulin resistance, and type 2 diabetes contribute to increased morbidity and mortality in humans. The db/db mouse is an important mouse model that displays many key features of the human disease. Herein, we used the drug pioglitazone, a thi
Externí odkaz:
https://doaj.org/article/88f48fc7d231478ab9c7243a3f87504b
Autor:
Thomas M. Martin, Susan J. Burke, Heidi M. Batdorf, David H. Burk, Sujoy Ghosh, Samuel D. Dupuy, Michael D. Karlstad, J. Jason Collier
Publikováno v:
The Journal of Immunology. 209:569-581
Type 1 diabetes (T1D) is classified as an autoimmune disease where pancreatic β-cells are specifically targeted by cells of the immune system. The molecular mechanisms underlying this process are not completely understood. Herein, we identified that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100bc265a6919ee9f002d92bcad35f18
https://doi.org/10.4049/jimmunol.2200065
https://doi.org/10.4049/jimmunol.2200065
Autor:
Susan J. Burke, Jessica L. Taylor, Heidi M. Batdorf, Robert C. Noland, David H. Burk, Yongmei Yu, Z. Elizabeth Floyd, J. Jason Collier
Publikováno v:
Biomedicines, Vol 9, Iss 1, p 22 (2020)
Glucocorticoids are clinically essential drugs used routinely to control inflammation. However, a host of metabolic side effects manifests upon usage beyond a few days. In the present study, we tested the hypothesis that seven-in-absentia mammalian h
Externí odkaz:
https://doaj.org/article/2d7b558caec44d42a3e054ce19e35936
Autor:
Cristal M. Hill, Diana C. Albarado, Lucia G. Coco, Redin A. Spann, Md Shahjalal Khan, Emily Qualls-Creekmore, David H. Burk, Susan J. Burke, J. Jason Collier, Sangho Yu, David H. McDougal, Hans-Rudolf Berthoud, Heike Münzberg, Andrzej Bartke, Christopher D. Morrison
Publikováno v:
Nature Communications. 13
Dietary protein restriction is increasingly recognized as a unique approach to improve metabolic health, and there is increasing interest in the mechanisms underlying this beneficial effect. Recent work indicates that the hormone FGF21 mediates the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::523e97d76480c3082d7a6b560732935c
https://doi.org/10.1038/s41467-022-29499-8
https://doi.org/10.1038/s41467-022-29499-8
Publikováno v:
Obesity (Silver Spring)
Objective Expression of zinc finger protein 423 (ZFP423), a key proadipogenic transcription factor in adipocyte precursor cells, is regulated by interaction of the proadipogenic early B-cell factor 1 (EBF1) and antiadipogenic ZFP521. The ubiquitin li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee880d249b435c056878b8b0db5f468a
https://doi.org/10.1002/oby.23013
https://doi.org/10.1002/oby.23013