Zobrazeno 1 - 10
of 55
pro vyhledávání: '"David H Brown Ripin"'
Autor:
David H Brown Ripin, Kelly Catlin, Linda Lewis, Danielle Resar, Carolyn Amole, Robert C Bollinger, Charles Flexner
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 75(Supplement_4)
Development of and increased access to generic oral medications to treat high-burden diseases including human immunodeficiency virus (HIV), tuberculosis, viral hepatitis, and malaria have had a major impact on reducing global morbidity and mortality.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0d15f884801ca0a1a61d38357b07bf
https://pubmed.ncbi.nlm.nih.gov/36410379
https://pubmed.ncbi.nlm.nih.gov/36410379
Publikováno v:
Practical Synthetic Organic Chemistry. :513-562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d297de6b38b421c17cf674825b550556
https://doi.org/10.1002/9781119448914.ch10
https://doi.org/10.1002/9781119448914.ch10
Autor:
David H. Brown Ripin, Adam R. Brown
Publikováno v:
Practical Synthetic Organic Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478bd123fbabf912d784be0a168e53d7
https://doi.org/10.1002/9781119448914.ch12
https://doi.org/10.1002/9781119448914.ch12
Autor:
David H. Brown Ripin, Chad A. Lewis
Publikováno v:
Practical Synthetic Organic Chemistry. :377-423
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::953131348bd98c535445078276c27d6f
https://doi.org/10.1002/9781119448914.ch7
https://doi.org/10.1002/9781119448914.ch7
Autor:
Michelle Moorhouse, Sarah Stacey, Godspower Akpomiemie, Ellisha Maharaj, David H Brown Ripin, Ambar Qavi, Joel W Sim, Phumla Sinxadi, Simiso Sokhela, Lubbe Wiesner, Celicia Serenata, Nonkululeko Mashabane, Willem D F Venter, Gila Chitauri, Tom H. Boyles, Natasha Arulappan, Andrew Hill, Carole L. Wallis
Publikováno v:
The Lancet HIV. 6:e428-e437
Pilot studies suggest that ritonavir-boosted darunavir could show high efficacy at doses below those currently approved. We investigated whether switch to 400 mg of darunavir boosted with 100 mg ritonavir once daily could show equivalent efficacy to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93a4a3dd88061a54186c241ed74ee78
https://doi.org/10.1016/s2352-3018(19)30081-5
https://doi.org/10.1016/s2352-3018(19)30081-5
Autor:
Willem Daniel Francois, Venter, Andrew, Kambugu, Matthew F, Chersich, Stephen, Becker, Andrew, Hill, Natasha, Arulappan, Michelle, Moorhouse, Mohammed, Majam, Godspower, Akpomiemie, Simiso, Sokhela, Selvamuthu, Poongulali, Charles, Feldman, Chris, Duncombe, David H Brown, Ripin, Alinda, Vos, Nagalingeswaran, Kumarasamy
Publikováno v:
Journal of Acquired Immune Deficiency Syndromes (1999)
Supplemental Digital Content is Available in the Text.
Background: Reducing doses of antiretroviral drugs, including stavudine (d4T), may lower toxicity, while preserving efficacy. There are substantial concerns about renal and bone toxicities o
Background: Reducing doses of antiretroviral drugs, including stavudine (d4T), may lower toxicity, while preserving efficacy. There are substantial concerns about renal and bone toxicities o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5694fe74c2b58181630409cbf91ea76
https://pubmed.ncbi.nlm.nih.gov/30640204
https://pubmed.ncbi.nlm.nih.gov/30640204
Publikováno v:
Green Techniques for Organic Synthesis and Medicinal Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b2b4760e30a3474978e10837ad2a088
https://doi.org/10.1002/9780470711828.ch26
https://doi.org/10.1002/9780470711828.ch26
Autor:
Joseph M. Fortunak, David H. Brown Ripin, Jack Melton, Stephen R. Houghton, Christopher N. Boddy
Publikováno v:
Tetrahedron. 66:8137-8144
A rapid, low temperature hydrolysis of tenofovir diethyl ester mediated by TMSCl and NaBr was identified and demonstrated to be superior to the current production method, TMSBr-mediated hydrolysis. This mild phosphonate ester hydrolysis was then coup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caf53486fcce89a0df141d6448cdd042
https://doi.org/10.1016/j.tet.2010.08.037
https://doi.org/10.1016/j.tet.2010.08.037
Autor:
Christopher N. Boddy, Frajovon Talley, Stephen R. Houghton, L. Nagaprasada Rao, Jack Melton, Shaik Muneer, Nylea Bivins, Gottumukkala V. Subbaraju, David S. Teager, Adrian Williams, Tricia Silverton, Stephen R. Byrn, Nardla Gopal Reddy, K. Chandra Shekar, Daniel T. Smith, S. Tirumala Jagadeesh, David H. Brown Ripin, R. Venkateswara Rao, Puma Chandra Ray, Kelly K. Catlin, Rodger W. Stringham, Joseph M. Fortunak, Shaik Mahaboob Basha, Ravi Mallikarjuna Reddy, K. Anesh Kumar
Publikováno v:
Organic Process Research & Development. 14:1194-1201
The three-step manufacturing process used in the synthesis of tenofovir disoproxil fumarate (1) was studied and optimized, leading to a more productive and robust process. The yield was improved from about 13% overall to 24%. Key process improvements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52ee6a6c0d36118dba25441a3778323a
https://doi.org/10.1021/op1001337
https://doi.org/10.1021/op1001337
Autor:
and Clifford N. Meltz, Pamela J. Clifford, David R. Bill, Gerald A. Weisenburger, James E. Phillips, David H. Brown Ripin, David J. am Ende
Publikováno v:
Organic Process Research & Development. 11:762-765
In order to run a peracid oxidation on multikilogram scale in a pilot plant facility with an acceptable level of risk, an extensive study of the thermal characteristics of the reaction, reactants, and quench was undertaken. A number of features were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2f2f895ebad05900b214d5c3f03b4b3
https://doi.org/10.1021/op700039r
https://doi.org/10.1021/op700039r