Zobrazeno 1 - 10
of 25
pro vyhledávání: '"David Højland Ipsen"'
Autor:
Kamilla Pedersen, David Højland Ipsen, Josephine Skat-Rørdam, Jens Lykkesfeldt, Pernille Tveden-Nyborg
Publikováno v:
Nutrients, Vol 15, Iss 11, p 2445 (2023)
The composition of dietary fatty acids may be important for the development and progression of metabolic syndrome and non-alcoholic steatohepatitis (NASH). This study investigated the effect of two high-fat diets based on coconut oil, containing pred
Externí odkaz:
https://doaj.org/article/b3d6ee46351248a587c2eca3b8394959
Autor:
Josephine Skat-Rørdam, David Højland Ipsen, Patrick Duncan Hardam, Markus Latta, Jens Lykkesfeldt, Pernille Tveden-Nyborg
Publikováno v:
Nutrients, Vol 13, Iss 8, p 2523 (2021)
Pharmacological treatment modalities for non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are scarce, and discoveries are challenged by lack of predictive animal models adequately reflecting severe human disease stages and co-morb
Externí odkaz:
https://doaj.org/article/4bf71c9b92f54267a739907dafbdde37
Publikováno v:
Biomedicines, Vol 9, Iss 1, p 93 (2021)
Nonalcoholic fatty liver disease (NAFLD) is becoming the leading chronic liver disease, negatively affecting the lives of millions of patients worldwide. The complex pathogenesis involves crosstalk between multiple cellular networks, but how the intr
Externí odkaz:
https://doaj.org/article/9a341472738a4621b1bd2e4d6d31bcb2
Publikováno v:
Nutrients, Vol 6, Iss 12, Pp 5473-5499 (2014)
Obesity and the subsequent reprogramming of the white adipose tissue are linked to human disease-complexes including metabolic syndrome and concurrent non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The dietary imp
Externí odkaz:
https://doaj.org/article/01e2affb78ef479f82e370590b3e3a78
Autor:
Jens Lykkesfeldt, Stefan E. Seemann, Pernille Tveden-Nyborg, Josephine Skat-Rørdam, Markus Latta, David Højland Ipsen
Publikováno v:
Biomedicines
Biomedicines; Volume 9; Issue 9; Pages: 1198
Biomedicines, Vol 9, Iss 1198, p 1198 (2021)
Skat-rørdam, J, Ipsen, D H, Seemann, S E, Latta, M, Lykkesfeldt, J & Tveden-nyborg, P 2021, ' Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model ', Biomedicines, vol. 9, no. 9, 1198 . https://doi.org/10.3390/biomedicines9091198
Biomedicines; Volume 9; Issue 9; Pages: 1198
Biomedicines, Vol 9, Iss 1198, p 1198 (2021)
Skat-rørdam, J, Ipsen, D H, Seemann, S E, Latta, M, Lykkesfeldt, J & Tveden-nyborg, P 2021, ' Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model ', Biomedicines, vol. 9, no. 9, 1198 . https://doi.org/10.3390/biomedicines9091198
The successful development of effective treatments against nonalcoholic steatohepatitis (NASH) is significantly set back by the limited availability of predictive preclinical models, thereby delaying and reducing patient recovery. Uniquely, the guine
Autor:
Patrick Duncan Hardam, Josephine Skat-Rørdam, Markus Latta, David Højland Ipsen, Jens Lykkesfeldt, Pernille Tveden-Nyborg
Publikováno v:
Nutrients
Volume 13
Issue 8
Skat-rørdam, J, Ipsen, D H, Hardam, P D, Latta, M, Lykkesfeldt, J & Tveden-nyborg, P 2021, ' Differential effects of dietary components on glucose intolerance and non-alcoholic steatohepatitis ', Nutrients, vol. 13, no. 8, 2523 . https://doi.org/10.3390/nu13082523
Nutrients, Vol 13, Iss 2523, p 2523 (2021)
Volume 13
Issue 8
Skat-rørdam, J, Ipsen, D H, Hardam, P D, Latta, M, Lykkesfeldt, J & Tveden-nyborg, P 2021, ' Differential effects of dietary components on glucose intolerance and non-alcoholic steatohepatitis ', Nutrients, vol. 13, no. 8, 2523 . https://doi.org/10.3390/nu13082523
Nutrients, Vol 13, Iss 2523, p 2523 (2021)
Pharmacological treatment modalities for non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are scarce, and discoveries are challenged by lack of predictive animal models adequately reflecting severe human disease stages and co-morb
Publikováno v:
Basic & Clinical Pharmacology & Toxicology
Skat-Rordam, J, Ipsen, D H, Lykkesfeldt, J & Tveden-Nyborg, P 2019, ' A role of peroxisome proliferator-activated receptor gamma in non-alcoholic fatty liver disease ', Basic & Clinical Pharmacology & Toxicology, vol. 124, no. 5, pp. 528-537 . https://doi.org/10.1111/bcpt.13190
Skat-Rordam, J, Ipsen, D H, Lykkesfeldt, J & Tveden-Nyborg, P 2019, ' A role of peroxisome proliferator-activated receptor gamma in non-alcoholic fatty liver disease ', Basic & Clinical Pharmacology & Toxicology, vol. 124, no. 5, pp. 528-537 . https://doi.org/10.1111/bcpt.13190
Non‐alcoholic fatty liver disease is becoming a major health burden, as prevalence increases and there are no approved treatment options. Thiazolidinediones target the nuclear receptor peroxisome proliferator‐activated receptor γ (PPARγ) and ha
Publikováno v:
Biomedicines
Biomedicines, Vol 9, Iss 365, p 365 (2021)
Zisser, A, Ipsen, D H & Tveden-Nyborg, P 2021, ' Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets? ', Biomedicines, vol. 9, no. 4, 365 . https://doi.org/10.3390/biomedicines9040365
Biomedicines, Vol 9, Iss 365, p 365 (2021)
Zisser, A, Ipsen, D H & Tveden-Nyborg, P 2021, ' Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets? ', Biomedicines, vol. 9, no. 4, 365 . https://doi.org/10.3390/biomedicines9040365
Hepatic fibrosis is the primary predictor of mortality in patients with non-alcoholic steatohepatitis (NASH). In this process, the activated hepatic stellate cells (HSCs) constitute the principal cells responsible for the deposition of a fibrous extr
Publikováno v:
Adv Nutr
Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases in the world, yet no pharmacotherapies are available. The lack of translational animal models is a major barrier impeding elucidation of disease mechanisms and drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dc2f1bb4cae9c73e57ea8ff2d97172
https://europepmc.org/articles/PMC7666900/
https://europepmc.org/articles/PMC7666900/
Autor:
R. H. Agerskov, Pernille Tveden-Nyborg, David Højland Ipsen, Jens Lykkesfeldt, Julie Hviid Klaebel
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Ipsen, D H, Agerskov, R H, Klaebel, J H, Lykkesfeldt, J & Tveden-Nyborg, P 2021, ' The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs ', Scientific Reports, vol. 11, 2955 . https://doi.org/10.1038/s41598-021-82643-0
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Ipsen, D H, Agerskov, R H, Klaebel, J H, Lykkesfeldt, J & Tveden-Nyborg, P 2021, ' The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs ', Scientific Reports, vol. 11, 2955 . https://doi.org/10.1038/s41598-021-82643-0
Variability in disease development due to differences in strains and breeders constitutes a substantial challenge in preclinical research. However, the impact of the breeder on non-alcoholic steatohepatitis (NASH) is not yet fully elucidated. This re