Zobrazeno 1 - 10
of 107
pro vyhledávání: '"David H, Wyllie"'
Autor:
Bridget Hilton, Daniel J. Wilson, Anne-Marie O’Connell, Dean Ironmonger, Justine K. Rudkin, Naomi Allen, Isabel Oliver, David H. Wyllie
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Understanding the genetic and environmental risk factors for serious bacterial infections in ageing populations remains incomplete. Utilising the UK Biobank (UKB), a prospective cohort study of 500,000 adults aged 40–69 years at recruitmen
Externí odkaz:
https://doaj.org/article/d4a593ca15b847809b0a98a467c0c88d
Autor:
Michael Riste, Pretin Davda, E. Grace Smith, David H. Wyllie, Martin Dedicoat, Simantini Jog, Steven Laird, Gerald Langman, Neil Jenkins, Jonathan Stevenson, Matthew K. O’Shea
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-5 (2021)
Abstract Background Joint replacement is an effective intervention and prosthetic joint infection (PJI) is one of the most serious complications of such surgery. Diagnosis of PJI is often complex and requires multiple modalities of investigation. We
Externí odkaz:
https://doaj.org/article/b6d36acebddd455e9852819267362c64
Autor:
David H. Wyllie, Jennifer A. Davidson, E. Grace Smith, Priti Rathod, Derrick W. Crook, Tim E.A. Peto, Esther Robinson, Tim Walker, Colin Campbell
Publikováno v:
EBioMedicine, Vol 34, Iss , Pp 122-130 (2018)
Background: Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeat (MIRU-VNTR) typing is widely used in high-income countries to determine Mycobacterium tuberculosis relatedness. Whole-genome sequencing (WGS) is known to deliver gre
Externí odkaz:
https://doaj.org/article/a1f0441539dc4ed9a81d6fedc95d2a50
Autor:
Oriol Mazariegos-Canellas, Trien Do, Tim Peto, David W. Eyre, Anthony Underwood, Derrick Crook, David H. Wyllie
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-7 (2017)
Abstract Background Large scale bacterial sequencing has made the determination of genetic relationships within large sequence collections of bacterial genomes derived from the same microbial species an increasingly common task. Solutions to the prob
Externí odkaz:
https://doaj.org/article/3abe30fe0fcc46168e96e5193c6332b8
Autor:
Pauline M. van Diemen, Darren B. Leneghan, Iona J. Brian, Kazutoyo Miura, Carole A. Long, Anita Milicic, Sumi Biswas, Christine S. Rollier, David H. Wyllie
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract A persistent goal of vaccine development is the enhancement of the immunogenicity of antigens while maintaining safety. One strategy involves alteration of the presentation of the antigen by combining antigens with a multimeric scaffold. Mul
Externí odkaz:
https://doaj.org/article/9486e757e39243498c51768ecb873839
Autor:
Bernadette C Young, Sarah G Earle, Sona Soeng, Poda Sar, Varun Kumar, Songly Hor, Vuthy Sar, Rachel Bousfield, Nicholas D Sanderson, Leanne Barker, Nicole Stoesser, Katherine RW Emary, Christopher M Parry, Emma K Nickerson, Paul Turner, Rory Bowden, Derrick W Crook, David H Wyllie, Nicholas PJ Day, Daniel J Wilson, Catrin E Moore
Publikováno v:
eLife, Vol 8 (2019)
Pyomyositis is a severe bacterial infection of skeletal muscle, commonly affecting children in tropical regions, predominantly caused by Staphylococcus aureus. To understand the contribution of bacterial genomic factors to pyomyositis, we conducted a
Externí odkaz:
https://doaj.org/article/196e44408db54cd89c458671036950d8
Autor:
Bernadette C Young, Chieh-Hsi Wu, N Claire Gordon, Kevin Cole, James R Price, Elian Liu, Anna E Sheppard, Sanuki Perera, Jane Charlesworth, Tanya Golubchik, Zamin Iqbal, Rory Bowden, Ruth C Massey, John Paul, Derrick W Crook, Timothy E Peto, A Sarah Walker, Martin J Llewelyn, David H Wyllie, Daniel J Wilson
Publikováno v:
eLife, Vol 6 (2017)
Bacteria responsible for the greatest global mortality colonize the human microbiota far more frequently than they cause severe infections. Whether mutation and selection among commensal bacteria are associated with infection is unknown. We investiga
Externí odkaz:
https://doaj.org/article/55edcb53a80d4e55a66f111381fdce3b
Autor:
Elizabeth R Allen, Pauline van Diemen, Yuko Yamaguchi, Claudia Lindemann, Elizabeth Soilleux, Christine Rollier, Fergal Hill, Jurgen Schneider, David H Wyllie
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154705 (2016)
PURPOSE:To develop and validate a sensitive and specific method of abscess enumeration and quantification in a preclinical model of Staphylococcus aureus infection. METHODS:S. aureus infected murine kidneys were fixed in paraformaldehyde, impregnated
Externí odkaz:
https://doaj.org/article/1a656a938bae4eef9253f2d18997b5bb
Autor:
Nicola De Maio, Tim E. A. Peto, Amy J. Mathers, Andrew Dodgson, Jeremy Swann, Ann Sarah Walker, Julie Cawthorne, Hang Tt Phan, Zoie Aiken, Anna C. Seale, Samuel Lipworth, David W Eyre, David H. Wyllie, Ryan George, P Quan, Nicole Stoesser, Derrick W. Crook, Alison Vaughan
BackgroundHealthcare-associated wastewater reservoirs and asymptomatic gastrointestinal patient colonisation by carbapenemase-producing Enterobacterales (CPE) can be important in nosocomial CPE dissemination and infection. We characterised these nich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6cb854390ef44d6beb59bc4a7576f9d
https://doi.org/10.1101/2021.11.26.21266267
https://doi.org/10.1101/2021.11.26.21266267
Autor:
Neville Q. Verlander, David H. Wyllie, David Edwards, Mark Reacher, Lucy Reeve, Eleanor Blakey
ObjectivesTo define risk factors for SARS-CoV-2 infection in University of Cambridge students during a period of increased incidence in October and November 2020.Study designSurveyMethodsRoutine public health surveillance identified a marked increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c7bd5e1e6cd4614c1d3e39fb45584a
https://doi.org/10.1101/2021.07.15.21260006
https://doi.org/10.1101/2021.07.15.21260006