Zobrazeno 1 - 10
of 81
pro vyhledávání: '"David H, Peng"'
Autor:
B. Leticia Rodriguez, Limo Chen, Yanli Li, Shucheng Miao, David H. Peng, Jared J. Fradette, Lixia Diao, Jessica M. Konen, Frank R. Rojas Alvarez, Luisa M. Solis, Xiaohui Yi, Aparna Padhye, Laura A. Gibson, Joshua K. Ochieng, Xiaofei Zhou, Jing Wang, Don L. Gibbons
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDespite significant clinical advancement with the use of immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC) there are still a major subset of patients that develop adaptive/acquired resistance. Understanding resistance
Externí odkaz:
https://doaj.org/article/b7f1eb8f62594da3a8e2703ca0fd91c7
Autor:
Yun-Fan Sun, Liang Wu, Shi-Ping Liu, Miao-Miao Jiang, Bo Hu, Kai-Qian Zhou, Wei Guo, Yang Xu, Yu Zhong, Xiao-Rui Zhou, Ze-Fan Zhang, Geng Liu, Sheng Liu, Ying-Hong Shi, Yuan Ji, Min Du, Nan-Nan Li, Gui-Bo Li, Zhi-Kun Zhao, Xiao-Yun Huang, Li-Qin Xu, Qi-Chao Yu, David H. Peng, Shuang-Jian Qiu, Hui-Chuan Sun, Michael Dean, Xiang-Dong Wang, Wen-Yuan Chung, Ashley R. Dennison, Jian Zhou, Yong Hou, Jia Fan, Xin-Rong Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Circulating tumour cells can be useful for monitoring disease progression but how they survive in the circulatory system is unclear. Here, the authors use single-cell sequencing of circulating tumour cells from multiple vascular sites in liver cancer
Externí odkaz:
https://doaj.org/article/156c23ef884041eba86aff0b60e3ab05
Autor:
David H. Peng, B. Leticia Rodriguez, Lixia Diao, Pierre-Olivier Gaudreau, Aparna Padhye, Jessica M. Konen, Joshua K. Ochieng, Caleb A. Class, Jared J. Fradette, Laura Gibson, Limo Chen, Jing Wang, Lauren A. Byers, Don. L. Gibbons
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Recent clinical trials combining MEK inhibitors with anti-PD-L1 in solid tumours show moderate responses. Here, the authors demonstrate that the combination of MEK inhibition and PD-L1 blockade in KRAS mutant lung cancer models leads to a transient t
Externí odkaz:
https://doaj.org/article/c550e9da14dd40faac0c52202ab9def2
Autor:
Won-Chul Lee, Alexandre Reuben, Xin Hu, Nicholas McGranahan, Runzhe Chen, Ali Jalali, Marcelo V. Negrao, Shawna M. Hubert, Chad Tang, Chia-Chin Wu, Anthony San Lucas, Whijae Roh, Kenichi Suda, Jihye Kim, Aik-Choon Tan, David H. Peng, Wei Lu, Ximing Tang, Chi-Wan Chow, Junya Fujimoto, Carmen Behrens, Neda Kalhor, Kazutaka Fukumura, Marcus Coyle, Rebecca Thornton, Curtis Gumbs, Jun Li, Chang-Jiun Wu, Latasha Little, Emily Roarty, Xingzhi Song, J. Jack Lee, Erik P. Sulman, Ganesh Rao, Stephen Swisher, Lixia Diao, Jing Wang, John V. Heymach, Jason T. Huse, Paul Scheet, Ignacio I. Wistuba, Don L. Gibbons, P. Andrew Futreal, Jianhua Zhang, Daniel Gomez, Jianjun Zhang
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-21 (2020)
Abstract Background Metastasis is the primary cause of cancer mortality accounting for 90% of cancer deaths. Our understanding of the molecular mechanisms driving metastasis is rudimentary. Results We perform whole exome sequencing (WES), RNA sequenc
Externí odkaz:
https://doaj.org/article/c29b76fbdc184076acd46b769c6e95c6
Autor:
David H. Peng, Bertha Leticia Rodriguez, Lixia Diao, Limo Chen, Jing Wang, Lauren A. Byers, Ying Wei, Harold A. Chapman, Mitsuo Yamauchi, Carmen Behrens, Gabriela Raso, Luisa Maren Solis Soto, Edwin Roger Parra Cuentes, Ignacio I. Wistuba, Jonathan M. Kurie, Don L. Gibbons
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream s
Externí odkaz:
https://doaj.org/article/219973ddbc6547bdba9bd0531b756cc7
Autor:
Roxsan Manshouri, Etienne Coyaud, Samrat T. Kundu, David H. Peng, Sabrina A. Stratton, Kendra Alton, Rakhee Bajaj, Jared J. Fradette, Rosalba Minelli, Michael D. Peoples, Alessandro Carugo, Fengju Chen, Christopher Bristow, Jeffrey J. Kovacs, Michelle C. Barton, Tim Heffernan, Chad J. Creighton, Brian Raught, Don L. Gibbons
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Non-small cell lung cancer (NSCLC) is often associated with metastasis to the lungs. Here, the authors perform independent screens and identify NuRD as a co-repressor of ZEB1, and demonstrate TBC1D2b as a downstream target of ZEB1/NuRD complex regula
Externí odkaz:
https://doaj.org/article/175dfc318ac14591a1188315ed141a14
Autor:
Jiehui Deng, David H. Peng, David Fenyo, Hao Yuan, Alfonso Lopez, Daniel S. Levin, Mary Meynardie, Mari Quinteros, Michela Ranieri, Soumyadip Sahu, Sally C. M. Lau, Elaine Shum, Vamsidhar Velcheti, Salman R. Punekar, Natasha Rekhtman, Catríona M. Dowling, Vajira Weerasekara, Yun Xue, Hongbin Ji, Yik Siu, Drew Jones, Aaron N. Hata, Takeshi Shimamura, John T. Poirier, Charles M Rudin, Takamitsu Hattori, Shohei Koide, Thales Papagiannakopoulos, Benjamin G. Neel, Nabeel Bardeesy, Kwok-kin Wong
Publikováno v:
bioRxiv
LKB1/STK11 is a serine/threonine kinase that plays a major role in controlling cell metabolism, resulting in potential therapeutic vulnerabilities in LKB1-mutant cancers. Here, we identify the NAD+degrading ectoenzyme, CD38, as a new target in LKB1-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664879e61c343e2d903f560a28e6eb38
https://europepmc.org/articles/PMC10153147/
https://europepmc.org/articles/PMC10153147/
Autor:
Don L. Gibbons, F. Xiao-Feng Qin, John V. Heymach, Ignacio I. Wistuba, Stephen E. Ullrich, Jing Wang, Ethan Dmitrovsky, Vassiliki A. Papadimitrakopoulou, Scott E. Woodman, Lauren Averett Byers, Masanori Kawakami, Jaime Rodriguez-Canales, Jingfen Zhu, Caleb A. Class, Youhong Fan, Carl M. Gay, Brett W. Carter, Weiyi Peng, Ferdinandos Skoulidis, Junna Oba, Pan Tong, Jonathon Roybal, Christin Ungewiss, David H. Peng, Jared J. Fradette, Di Peng, Qiang Zhao, Anfei Huang, Philip L. Lorenzi, Lin Tan, Xi Liu, Tina Cascone, Pamela A. Villalobos, Yanli Li, B. Leticia Rodriguez, Xiaohui Yi, Yongbin Yang, Lixia Diao, Limo Chen
Genes differentially expressed between IgG control and anti-PD-L1 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c4546034d1bf67810222d236f67110
https://doi.org/10.1158/2159-8290.22532345
https://doi.org/10.1158/2159-8290.22532345
Autor:
Peter Olson, James G. Christensen, Kwok-Kin Wong, Adam Pavlicek, Julio Fernandez-Banet, Sole Gatto, Jill Hallin, Lars D. Engstrom, Jiehui Deng, David H. Peng, Lauren Hargis, Ruth Aranda, Niranjan Sudhakar, Andrew Calinisan, Shuai Li, David M. Briere
KRASG12C inhibitors, including MRTX849, are promising treatment options for KRAS-mutant non–small cell lung cancer (NSCLC). PD-1 inhibitors are approved in NSCLC; however, strategies to enhance checkpoint inhibitor therapy (CIT) are needed. KRASG12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0679ee9794421d5e87ada96097d171a6
https://doi.org/10.1158/1535-7163.c.6543400.v1
https://doi.org/10.1158/1535-7163.c.6543400.v1
Autor:
Lauren A. Byers, Don L. Gibbons, Carl M. Gay, Jing Wang, John V. Heymach, You-Hong Fan, B. Leticia Rodriguez, David H. Peng, Robert J. Cardnell, Lixia Diao, Li Shen, Qi Wang, Carminia M. Della Corte, Kasey R. Cargill, C. Allison Stewart, Kavya Ramkumar
Supplementary Fig. S2: Spectra of EMT score and AXL expression across different tumor types.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288e1609e52beaaa25a263cfb26a1533
https://doi.org/10.1158/1541-7786.22526639.v1
https://doi.org/10.1158/1541-7786.22526639.v1