Zobrazeno 1 - 10
of 32
pro vyhledávání: '"David H, McDougal"'
Autor:
Cristal M. Hill, Diana C. Albarado, Lucia G. Coco, Redin A. Spann, Md Shahjalal Khan, Emily Qualls-Creekmore, David H. Burk, Susan J. Burke, J. Jason Collier, Sangho Yu, David H. McDougal, Hans-Rudolf Berthoud, Heike Münzberg, Andrzej Bartke, Christopher D. Morrison
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The restriction of dietary protein or amino acid intake is well established to extend lifespan in multiple species. Here, the authors show that the endocrine hormone FGF21 is necessary for dietary protein restriction to extend lifespan and improve me
Externí odkaz:
https://doaj.org/article/4650d44069f84d4b904fb8abe5136b6d
Autor:
Cristal M. Hill, Thomas Laeger, Diana C. Albarado, David H. McDougal, Hans-Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Dietary protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy expenditure and food intake, and these effects require the metabolic hormone fibroblast growth factor 21 (FGF21). Here we test whether the induction of
Externí odkaz:
https://doaj.org/article/4f8959552de94e438407d316dc830a05
Autor:
David H McDougal, Marina A. DuVall, Christopher D. Morrison, Laura A. Moldovan, Rajvi Jariwala
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 10-11 (2020)
OBJECTIVES/GOALS: We have recently shown that mice exposed to six days of 60% caloric restriction acutely display reduced hypoglycemia-induced glucagon release following refeeding, and that this effect is concurrent with low leptin levels. The curren
Externí odkaz:
https://doaj.org/article/c13c73820dfe403a8d1274564f1a5629
Autor:
Leticia Maria de Souza Cordeiro, Lauren Bainbridge, Nagavardhini Devisetty, David H. McDougal, Dorien J. M. Peters, Kavaljit H. Chhabra
Publikováno v:
Diabetologia, 65(6), 1032-1047. SPRINGER
Diabetologia
Diabetologia
Aims/hypothesis: Renal GLUT2 is increased in diabetes, thereby enhancing glucose reabsorption and worsening hyperglycaemia. Here, we determined whether loss of Glut2 (also known as Slc2a2) specifically in the kidneys would reverse hyperglycaemia and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b87b14d9a29cab8b7bd58f4a16ce70
https://doi.org/10.1007/s00125-022-05676-8
https://doi.org/10.1007/s00125-022-05676-8
Autor:
David H. McDougal, Redin A. Spann, Cristal M. Hill, Christopher D. Morrison, Marina A. DuVall
Publikováno v:
J Diabetes Complications
Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats displa
Autor:
Cristal M, Hill, Diana C, Albarado, Lucia G, Coco, Redin A, Spann, Md Shahjalal, Khan, Emily, Qualls-Creekmore, David H, Burk, Susan J, Burke, J Jason, Collier, Sangho, Yu, David H, McDougal, Hans-Rudolf, Berthoud, Heike, Münzberg, Andrzej, Bartke, Christopher D, Morrison
Publikováno v:
Nature communications. 13(1)
Dietary protein restriction is increasingly recognized as a unique approach to improve metabolic health, and there is increasing interest in the mechanisms underlying this beneficial effect. Recent work indicates that the hormone FGF21 mediates the m
Publikováno v:
Diabetes. 69
Aging and obesity are risk factors linked to the impairment of both energy and glucose homeostasis. Conversely, reducing caloric intake or the intake of select macronutrients or amino acids, including dietary protein restriction (DPR) and methionine
Autor:
Hunter X. Sikaffy, Cristal M. Hill, David H. McDougal, Marina A. DuVall, Christopher D. Morrison, Rajvi Jariwala
Publikováno v:
Diabetes. 69
Background: Hypoglycemia-associated autonomic failure (HAAF) is a significant barrier to achieving optimal glucose levels in persons with diabetes. Our group and others have demonstrated that low leptin levels are concurrent with impaired hypoglycemi
Publikováno v:
Obesity (Silver Spring)
OBJECTIVE This study aimed to investigate a novel approach for determining the effects of energy-standardized dinner meals (high-fat and low-fat) on respiratory exchange ratio (RER) dynamics and metabolic flexibility. METHODS Using a randomized cross
Autor:
Hans-Rudolf Berthoud, Christopher D. Morrison, David H. McDougal, Cristal M. Hill, Emily Qualls-Creekmore, Paul L. Soto, Heike Münzberg, Sangho Yu
Publikováno v:
Endocrinology
The ability to respond to variations in nutritional status depends on regulatory systems that monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient restriction. There is ample evidence that the restriction of wa