Zobrazeno 1 - 10
of 121
pro vyhledávání: '"David H, Farrell"'
Autor:
Lucy Z. Kornblith, Bindhya Sadhanandhan, Sreepriya Arun, Rebecca Long, Alicia J. Johnson, Jamie Noll, C. N. Ramchand, John K. Olynyk, David H. Farrell
Publikováno v:
Research square.
Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ' fibrinogen (GPF), in 103 hospitalized patients with COVID-19 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56480af6b5e18c21618807a3ef23597c
https://pubmed.ncbi.nlm.nih.gov/36299432
https://pubmed.ncbi.nlm.nih.gov/36299432
Autor:
David H. Farrell, Susan E. Rowell, Kelly A. Fair, Martin A. Schreiber, Elizabeth A. Rick, Cole Hilliard, Ronald R. Barbosa, Amber Lin, Holly E. Hinson, Elizabeth N. Dewey, Belinda H. McCully, Rondi K. Dean
Publikováno v:
J Neurotrauma
Progression of intracranial hemorrhage (PICH) is a significant cause of secondary brain injury in patients with traumatic brain injury (TBI). Previous studies have implicated a variety of mediators that contribute to PICH. We hypothesized that patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d92149af2b8f08173135dabbdac2463
https://doi.org/10.1089/neu.2018.6234
https://doi.org/10.1089/neu.2018.6234
Autor:
Lucy Z Kornblith, Bindhya Sadhanandhan, Sreepriya Arun, Rebecca Long, Alicia J Johnson, Jamie Noll, CN Ramchand, John K Olynyk, David H Farrell
Publikováno v:
Blood. 140:2749-2750
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37ac2ec4367d2e8a324924981e6b7783
https://doi.org/10.1182/blood-2022-162765
https://doi.org/10.1182/blood-2022-162765
Autor:
John M. Tallon, Elizabeth N. Dewey, Rajesh R. Gandhi, Charles E. Wade, Brian Tibbs, Alexandra Dixon, Delores Kannas, Elizabeth A. Rick, David J. Dries, Tom P. Aufderheide, Myron L. Weisfeldt, David H. Farrell, John S. Garrett, Ralph J. Frascone, Carolyn Williams, Susan E. Rowell, Bryce R.H. Robinson, Laurie J. Morrison, Martin A. Schreiber, Jonathan Jui, Jeannie Callum, Jason T. McMullan, Belinda H. McCully
Publikováno v:
Journal of Trauma and Acute Care Surgery. 89:900-907
BACKGROUND No Food and Drug Administration-approved medication improves outcomes following traumatic brain injury (TBI). A forthcoming clinical trial that evaluated the effects of two prehospital tranexamic acid (TXA) dosing strategies compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa376ea77c448cc15afdd3505ca38fa
https://doi.org/10.1097/ta.0000000000002932
https://doi.org/10.1097/ta.0000000000002932
Autor:
Elizabeth A. Rick, Martin A. Schreiber, Elizabeth N. Dewey, David H. Farrell, Susan E. Rowell
Publikováno v:
Am J Surg
Background γ′ fibrinogen is an alternatively-spliced fibrinogen variant that displays different coagulation parameters in vitro than the major form of fibrinogen. Purified γ′ fibrinogen has slower clotting kinetics than unfractionated fibrinoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078cef7b925bc5cb516ca571ac950834
https://doi.org/10.1016/j.amjsurg.2019.12.028
https://doi.org/10.1016/j.amjsurg.2019.12.028
Autor:
David H. Farrell, Matthew Hudkins, Heather Hamilton, Samantha J. Underwood, Elizabeth N. Dewey, Diana E. Kazmierczak, Steven C. Kazmierczak, William B. Messer, Akram Khan, Martin A. Schreiber
BackgroundCOVID-19 progression can be accompanied by a “cytokine storm” that leads to secondary sequelae such as thrombosis and acute respiratory distress syndrome. Several inflammatory cytokines have been associated with COVID-19 progression, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31432837e3ce044d029a2ac10d76b55e
https://doi.org/10.1101/2022.01.20.22269321
https://doi.org/10.1101/2022.01.20.22269321
Publikováno v:
Seminars in thrombosis and hemostasis. 47(5)
Posttraumatic coagulopathy involves disruption of both the coagulation and fibrinolytic pathways secondary to tissue damage, hypotension, and inflammatory upregulation. This phenomenon contributes to delayed complications after traumatic brain injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dfc0f5727e1487bcb7ada711c04ba2
https://pubmed.ncbi.nlm.nih.gov/33878779
https://pubmed.ncbi.nlm.nih.gov/33878779
Autor:
Mary E. Condron, Taylor N. Anderson, Elizabeth N. Dewey, Holly E. Hinson, Lelani Lealiiee, David H. Farrell, Susan E. Rowell
Publikováno v:
Journal of Trauma and Acute Care Surgery. 85:888-893
BACKGROUNDTraumatic injury is associated with an increased risk of coagulopathy and venous thrombosis. plasminogen activator inhibitor-1 (PAI-1) is a procoagulant molecule that inhibits tPA/uPA, thrombomodulin, and activated protein C. We hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ace51bf9b50aab9b8440ddc88f129eb
https://doi.org/10.1097/ta.0000000000002040
https://doi.org/10.1097/ta.0000000000002040
Autor:
Filomena A, Carvalho, Ana Filipa, Guedes, Cedric, Duval, Fraser L, Macrae, Luke, Swithenbank, David H, Farrell, Robert As, Ariëns, Nuno C, Santos
Publikováno v:
International Journal of Nanomedicine
Background Erythrocyte aggregation, a cardiovascular risk factor, is increased by high plasma fibrinogen levels. Here, the effect of different fibrinogen mutations on binding to its human erythrocyte receptor was assessed in order to identify the int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47a5b5fd6b21be8f714af5f57d1dba52
https://pubmed.ncbi.nlm.nih.gov/29662311
https://pubmed.ncbi.nlm.nih.gov/29662311
Publikováno v:
Thrombosis Research. 131:89-93
Fibrinogen is a major structural protein in blood clots, and is also a well-known acute phase reactant. The γ chain gene of fibrinogen has two alternative splice variants, γA and γ' chains. γ' fibrinogen constitutes about 7% of total fibrinogen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac66cfe5ee26c6cca4bf5b153c8bd6d2
https://doi.org/10.1016/j.thromres.2012.09.017
https://doi.org/10.1016/j.thromres.2012.09.017