Výsledky vyhledávání

Akademický článek

Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1.

Autor: Sandra Fausia Soukup, Joaquim Culi, David Gubb

Publikováno v: PLoS Genetics, Vol 5, Iss 6, p e1000532 (2009)

The humoral response to fungal and Gram-positive infections is regulated by the serpin-family inhibitor, Necrotic. Following immune-challenge, a proteolytic cascade is activated which signals through the Toll receptor. Toll activation results in a ra

Externí odkaz: https://doaj.org/article/188fc74b1597443188f0f6d3530b6246

Zobrazit plný text záznamu

prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies

Autor: Salleh N. Ehaideb, Gary J. Iacobucci, Alexander G. Bassuk, Shermali Gunawardena, Cathryn Cranston, Chun-Fang Wu, J. Robert Manak, David Gubb, Atulya Iyengar, Jeffrey D. Axelrod, Atsushi Ueda

Publikováno v: Proceedings of the National Academy of Sciences. 111:11187-11192

Recent analyses in flies, mice, zebrafish, and humans showed that mutations in prickle orthologs result in epileptic phenotypes, although the mechanism responsible for generating the seizures was unknown. Here, we show that Prickle organizes microtub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f1ffc90b2ee1cfe7ea92fc68fdbd2f
https://doi.org/10.1073/pnas.1403357111

Zobrazit plný text záznamu

Spn1 Regulates the GNBP3-Dependent Toll Signaling Pathway in Drosophila melanogaster

Autor: David Gubb, Arantza Sanz-Parra, Ane Fullaondo, Susana García-Sánchez, Emma Recio, So Young Lee

Publikováno v: Molecular and Cellular Biology. 31:2960-2972

The Drosophila genome encodes 29 serpins, most of unknown function. We show here that Spn1 is an active protease inhibitor of the serpin superfamily. Spn1 inhibits trypsin in vitro and regulates the Toll-mediated immune response in vivo. Expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfec5f2dc19c7c22e9eba66d2781cd2
https://doi.org/10.1128/mcb.01397-10

Zobrazit plný text záznamu

Molecular dissection of Drosophila Prickle isoforms distinguishes their essential and overlapping roles in planar cell polarity

Autor: David Gubb, Yung-Yao Lin

Publikováno v: Developmental Biology. 325(2):386-399

Prickle-Spiny-Legs (Pk) is an essential component of the planar cell polarity (PCP) pathway, together with Frizzled (Fz) and Dishevelled (Dsh). A role for Pk was proposed to mediate feedback amplification of asymmetric Fz/Dsh activity across cell bou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e479bc8925b67e9572b69917ffab9b

Zobrazit plný text záznamu

The multiple-wing-hairs Gene Encodes a Novel GBD–FH3 Domain-Containing Protein That Functions Both Prior to and After Wing Hair Initiation

Autor: John Roote, Jie Yan, Glynnis Johnson, Paul N. Adler, David Huen, Terri Morely, David Gubb

Publikováno v: Genetics. 180:219-228

The frizzled signaling/signal transduction pathway controls planar cell polarity (PCP) in both vertebrates and invertebrates. Epistasis experiments argue that in the Drosophila epidermis multiple wing hairs (mwh) acts as a downstream component of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0120582b7eb8eb5e1a8be48f9345c1
https://doi.org/10.1534/genetics.108.091314

Zobrazit plný text záznamu

The DrosDel Deletion Collection: A Drosophila Genomewide Chromosomal Deficiency Resource

Publikováno v: Genetics. 177:615-629

We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering ∼77% of the Release 5.1 genome. Using a previously reported collection of FRT-bearing P-element

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f126437eb316d33d620255d9b2016259
https://doi.org/10.1534/genetics.107.076216

Zobrazit plný text záznamu

Neuroserpin Binds Aβ and Is a Neuroprotective Component of Amyloid Plaques in Alzheimer Disease

Autor: Kerri J. Kinghorn, David A. Lomas, Damian C. Crowther, Charlotte Nerelius, Howard T. Chang, David Gubb, Lynda K. Sharp, Richard L. Davis, Jan Johansson, Clare Green

Publikováno v: Journal of Biological Chemistry. 281:29268-29277

Alzheimer disease is characterized by extracellular plaques composed of Abeta peptides. We show here that these plaques also contain the serine protease inhibitor neuroserpin and that neuroserpin forms a 1:1 binary complex with the N-terminal or midd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc012a8c8d9067860e595d039d7f92e
https://doi.org/10.1074/jbc.m600690200

Zobrazit plný text záznamu

The DrosDel Collection

Publikováno v: Genetics. 167:797-813

We describe a collection of P-element insertions that have considerable utility for generating custom chromosomal aberrations in Drosophila melanogaster. We have mobilized a pair of engineered P elements, p{RS3} and p{RS5}, to collect 3243 lines unam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afcab6d1788fa403aa2a589ea0e833e7
https://doi.org/10.1534/genetics.104.026658

Zobrazit plný text záznamu

Prickle Mediates Feedback Amplification to Generate Asymmetric Planar Cell Polarity Signaling

Autor: Raphaël Rousset, David Gubb, Matthew P. Scott, Joshua M. Shulman, David Tree, Jeffrey D. Axelrod

Publikováno v: Cell. 109(3):371-381

Planar cell polarity signaling in Drosophila requires the receptor Frizzled and the cytoplasmic proteins Dishevelled and Prickle. From initial, symmetric subcellular distributions in pupal wing cells, Frizzled and Dishevelled become highly enriched a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0237615a78e53e8d398ea5ab733c610d

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání