Zobrazeno 1 - 10
of 37
pro vyhledávání: '"David Gravestock"'
Autor:
Christopher M. Baker, Rob Carson, Matthew Brian Hotson, Jim Harrison, David Gravestock, Martin Pouliot, Konstantinos Papachristos, Alan John Dowling, Nathan J. Kidley
Publikováno v:
Journal of chemical information and modeling. 60(8)
Databases of small, potentially bioactive molecules are ubiquitous across the industry and academia. Designed such that each unique compound should appear only once, the multiplicity of ways in which many compounds can be represented means that these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78de4cd967f892f9f2e08c8206f8003d
https://pubmed.ncbi.nlm.nih.gov/32644790
https://pubmed.ncbi.nlm.nih.gov/32644790
Publikováno v:
Organic Preparations and Procedures International. 48:89-221
Isocyanides were formally discovered by Gautier1 and Hofmann2 in 1867 but the history of isocyanide chemistry in fact predates this discovery. Lieke carried out the first isocyanide synthesis in 18...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eb558f4f8d34b5ff52bdc4a91d9e216
https://doi.org/10.1080/00304948.2016.1138072
https://doi.org/10.1080/00304948.2016.1138072
Autor:
Supannee Taweechai, Heinrich C. Hoppe, David Gravestock, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan, Natasha I. Kolesnikova, Anna C.U. Lourens, Amanda L. Rousseau, Robyn L. van Zyl
Publikováno v:
Organic & Biomolecular Chemistry. 14:7899-7911
The design, synthesis and biological evaluation of a series of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4- diamines is described. These compounds exhibited in vitro antiplasmodial activity in the low nanomolar range against both drug sensitive and drug re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0840afe8a9cb5c69849fbbcc13ad7c02
https://doi.org/10.1039/c6ob01350c
https://doi.org/10.1039/c6ob01350c
Publikováno v:
ChemInform. 47
Isocyanides were formally discovered by Gautier1 and Hofmann2 in 1867 but the history of isocyanide chemistry in fact predates this discovery. Lieke carried out the first isocyanide synthesis in 18...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9398ca144320106d9bca91195b82015a
https://doi.org/10.1002/chin.201622244
https://doi.org/10.1002/chin.201622244
Autor:
Lindiwe A. Nkabinde, David Gravestock, Heinrich C. Hoppe, Moira L. Bode, Anna C.U. Lourens, Amanda L. Rousseau
Publikováno v:
Tetrahedron Letters. 53:3225-3229
The authors wish to thank the Innovation Fund (now the Technology Innovation Agency, South Africa) for financial support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b96a9fe420b331f7ad7769183321e0a
https://doi.org/10.1016/j.tetlet.2012.04.018
https://doi.org/10.1016/j.tetlet.2012.04.018
Autor:
Heinrich C. Hoppe, Simon Sana Moleele, Paul A. Steenkamp, David Gravestock, Lindiwe A. Nkabinde, Tasmiyah Khan, Stephen C. Pelly, Moira L. Bode, Christiaan W. van der Westhuyzen
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4227-4237
During random screening of a small in-house library of compounds, certain substituted imidazo[1,2- a ]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds was prepared using the Groeb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b885cc886bd56959b7165a891038c50
https://doi.org/10.1016/j.bmc.2011.05.062
https://doi.org/10.1016/j.bmc.2011.05.062
Publikováno v:
European Journal of Organic Chemistry. 2005:505-511
N-Bridgehead pyrroles are efficiently prepared from cyclic secondary vinylogous carbamates using a two-step sequence. This sequence involves C-propargylation followed by a silver-catalyzed intramolecular hydroamination. Hydroamination is brought abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32e8404bf012caf4db53a6783b5bad80
https://doi.org/10.1002/ejoc.200400598
https://doi.org/10.1002/ejoc.200400598
Autor:
Martin C. Dovey, David Gravestock
Publikováno v:
Synthesis. 2003:0523-0530
The silver nitrate promoted reaction of propargyl bromide with (Z)-4-amino-3-penten-2-ones and (Z)-3-amino-2-butenoates provides rapid access to β-(Z)-[(1-propynyl)amino]enones and β-[(Z)-(1-propynyl)amino]enoates respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::567a38ed7a38517e0491e25681f4ef1f
https://doi.org/10.1055/s-2003-37654
https://doi.org/10.1055/s-2003-37654
Autor:
David Gravestock, Ian G. Peirson
Publikováno v:
Tetrahedron Letters. 41:3497-3500
Intramolecular coupling reactions of enynes 2-[1-(2-propynyl)tetrahydro-2H-pyrrol-2-ylidene]acetonitrile (10) and ethyl 2-[1-(2-propynyl)tetrahydro-2H-pyrrol-2-ylidene]acetate (11), using 9-BBN, catecholborane and alkaline silver nitrate, afforded th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8842b6a566efbbc27d90d99bd1d52063
https://doi.org/10.1016/s0040-4039(00)00406-8
https://doi.org/10.1016/s0040-4039(00)00406-8
Autor:
David Gravestock, Joseph P. Michael
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1919-1928
Syntheses of racemic (5R*,8R*,8aS*)-8-methyl-5-pentylindolizidine (indolizidine 209B) (±)-1 and its hitherto unknown (5R*,8S*,8aS*) diastereomer (±)-20 were accomplished in eight steps from pyrrolidine-2-thione and ethyl oct-2-enoate. Key steps inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b95ea94b76497c4033afbf3876b39c80
https://doi.org/10.1039/b001853h
https://doi.org/10.1039/b001853h