Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David Granadier"'
Autor:
Sinéad Kinsella, Cindy A. Evandy, Kirsten Cooper, Antonella Cardinale, Lorenzo Iovino, Paul deRoos, Kayla S. Hopwo, Colton W. Smith, David Granadier, Lucas B. Sullivan, Enrico Velardi, Jarrod A. Dudakov
Endogenous thymic regeneration is a crucial process that allows for the renewal of immune competence following stress, infection or cytoreductive conditioning. Fully understanding the molecular mechanisms driving regeneration will uncover therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18efc9a131627f508f25e89f68542965
https://doi.org/10.1101/2023.01.19.524800
https://doi.org/10.1101/2023.01.19.524800
Autor:
Lorenzo Iovino, Kirsten Cooper, Paul DeRoos, Cindy Evandy, David Granadier, Sinéad Kinsella, Dante Denny Acenas, Jarrod A Dudakov
Publikováno v:
Blood. 140:10206-10207
Autor:
David Granadier, Kirsten Cooper, Sinéad Kinsella, Cindy Evandy, Lorenzo Iovino, Paul DeRoos, Steve Shannon-Sevillano, Dante Denny Acenas, Jarrod A Dudakov
Publikováno v:
Blood. 140:1169-1170
Autor:
Lorenzo Iovino, Kirsten Cooper, Paul deRoos, Sinéad Kinsella, Cindy Evandy, Tamas Ugrai, Francesco Mazziotta, Kathleen S. Ensbey, David Granadier, Kayla Hopwo, Colton Smith, Alex Gagnon, Sara Galimberti, Mario Petrini, Geoffrey R. Hill, Jarrod A. Dudakov
Prolonged lymphopenia represents a major clinical problem after cytoreductive therapies such as chemotherapy and the conditioning required for hematopoietic stem cell transplant (HCT), contributing to the risk of infections and malignant relapse. Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2648072dd1735d66531c230f523429cd
http://hdl.handle.net/11568/1145218
http://hdl.handle.net/11568/1145218
Autor:
Anastasia I. Kousa, Lorenz Jahn, Kelin Zhao, Angel E. Flores, David Granadier, Kirsten Cooper, Julie M. Sheridan, Andri Lemarquis, Lisa Sikkema, Kimon V. Argyropoulos, Jennifer Tsai, Amina Lazrak, Katherine Nichols, Nichole Lee, Romina Ghale, Florent Malard, Hana Andrlova, Antonio L.C. Gomes, Enrico Velardi, Salma Youssef, Marina B. da Silva, Melissa Docampo, Roshan Sharma, Linas Mazutis, Verena C. Wimmer, Kelly L. Rogers, Susan DeWolf, Brianna Gipson, Manu Setty, Dana Pe’er, Nancy R. Manley, Daniel H.D. Gray, Jarrod A. Dudakov, Marcel R.M. van den Brink
SUMMARYThe thymus is essential for establishing adaptive immunity yet undergoes age-related atrophy leading to compromised immune responsiveness. The thymus is also extremely sensitive to acute insult and although capable of regeneration, this capaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5a98885855bfe93656ffd3ed4004f71
https://doi.org/10.1101/2021.12.16.472014
https://doi.org/10.1101/2021.12.16.472014
Autor:
Sinéad Kinsella, Cindy Anggelica Evandy, Kirsten Cooper, Kayla Hopwo, Lorenzo Iovino, Paul deRoos, Colton Smith, David Granadier, Jarrod A Dudakov
Publikováno v:
The Journal of Immunology. 208:47.17-47.17
Competent T cell development relies on efficient functioning of the thymus, which is extremely sensitive to acute and chronic insults, but has a remarkable ability to regenerate. We identified that cell-specific metabolic remodeling triggers key mole
Autor:
Eric Perkey, Jeffrey C. Nolz, Freddy Radtke, Alexander Dils, Todd V. Brennan, Bruce R. Blazar, Jooho Chung, Dave Maurice De Sousa, David Granadier, Leolene J Carrington, Burkhard Ludewig, Nathalie Labrecque, Ivan Maillard, Christian W. Siebel, Ute Koch
Publikováno v:
J Immunol
Notch signaling is emerging as a critical regulator of T cell activation and function. However, there is no reliable cell surface indicator of Notch signaling across activated T cell subsets. In this study, we show that Notch signals induce upregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845715ff11ab082fde369e34427cfcd1
https://europepmc.org/articles/PMC7306398/
https://europepmc.org/articles/PMC7306398/
Autor:
Emily R Levy, Richard W. Childs, Stephanie Pierre, Mala Chakraborty, Elena Cherkasova, Stefan Barisic, Robert Reger, Long Chen, Susan Doh, Giacomo C. Waller, David S.J. Allan, Kate Stringaris, Vicky Li, David Granadier
Publikováno v:
Cancer Research. 79:1434-1434
Chimeric Antigen Receptors (CAR)-T cells are genetically modified to express an extracellular binding domain, transmembrane domain and intracellular signaling domain. The extracellular binding domain is usually derived from antibodies; however, it ca
Autor:
Anastasia N. Tikhonova, David Granadier, Iannis Aifantis, Nathalie Labrecque, Freddy Radtke, Ann Friedman, Jooho Chung, Ute Koch, Léolène Carrington, Chris Siebel, Ivan Maillard, Alexander Dils, Bruce R. Blazar, Eric Perkey
Notch signals drive pathogenic T cell alloreactivity in mouse models of allogeneic bone marrow transplantation (allo-BMT) leading to lethal graft-versus-host disease (GVHD). In a mouse model of MHC-mismatched allo-BMT with high intensity whole body c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f777611f59cd581fd830a682de6e11c
https://infoscience.epfl.ch/record/267276
https://infoscience.epfl.ch/record/267276