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Autor:
Henry S. Friedman, David Graden, Peter J. Houghton, Roger E. McLendon, Janice E. Zilisch, Allan H. Friedman, Ilkcan Cokgor, Susan G. Arbuck, Tracy Kerby, Scott Fields
Publikováno v:
Cancer. 85:1160-1165
BACKGROUND Topotecan activity was evaluated for the treatment of malignant glioma. METHODS Sixty-three patients with newly diagnosed (n = 25) or recurrent (n = 38) malignant glioma were treated with topotecan at a dose of 2.6 mg/m2 over a 72-hour per