Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism

Autor: Carlos Kiyoshi Katashima, Thayana de Oliveira Micheletti, Renata Rosseto Braga, Rodrigo Stellzer Gaspar, Ludger J. E. Goeminne, Alexandre Moura-Assis, Barbara Moreira Crisol, Rafael S. Brícola, Vagner Ramon R. Silva, Camila de Oliveira Ramos, Alisson L. da Rocha, Mariana Rosolen Tavares, Fernando Moreira Simabuco, Valquiria Aparecida Matheus, Lucas Buscaratti, Henrique Marques-Souza, Patricia Pazos, David Gonzalez-Touceda, Sulay Tovar, María del Carmen García, Jose Cesar Rosa Neto, Rui Curi, Sandro Massao Hirabara, Patrícia Chakur Brum, Patrícia Oliveira Prada, Leandro P. de Moura, José Rodrigo Pauli, Adelino S. R. da Silva, Dennys Esper Cintra, Licio A. Velloso, Eduardo Rochete Ropelle

Publikováno v: Science Advances
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation in mouse skeletal muscle. B

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