Zobrazeno 1 - 10
of 29
pro vyhledávání: '"David Gonzalez Martinez"'
Autor:
David Gonzalez-Martinez, Lee Roth, Thomas R. Mumford, Juan Guan, Anh Le, Robert C. Doebele, Bo Huang, Asmin Tulpule, Magdalena Niewiadomska-Bugaj, Trever G. Bivona, Lukasz J. Bugaj
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Drug resistance remains a challenge for targeted therapy of cancers driven by EML4-ALK and related fusion oncogenes. EML4-ALK forms cytoplasmic protein condensates, which result from networks of interactions between oncogene and adapter prot
Externí odkaz:
https://doaj.org/article/369d4a9ed829495a9689692c1e1918f3
Autor:
Alexander Chan, Rebecca M. Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J. Bugaj, George M. Burslem, Michael J. Mitchell, Andrew Tsourkas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Recently, targeted degradation has emerged as a powerful therapeutic modality. Relying on “event-driven” pharmacology, proteolysis targeting chimeras (PROTACs) can degrade targets and are superior to conventional inhibitors against undru
Externí odkaz:
https://doaj.org/article/c8e03480a79f42f1b05ddadc6ec0b9d3
Autor:
César A. Chagoyen Méndez, David Gonzalez Martinez, Gregorio B. Aragón López, José Leiva Pérez
Publikováno v:
Revista Centro Azúcar, Vol 35, Iss 2 (2008)
Este artículo introduce la motivación por los beneficios del enlace del Análisis por Elementos Finitos con los Ensayos en estructuras. En él aparece una aplicación típica en el campo del análisis estático de estructuras, específicamente a un
Externí odkaz:
https://doaj.org/article/cc39651015a2478291a1391c7b32e23f
Autor:
William Benman, Saachi Datta, David Gonzalez-Martinez, Gloria Lee, Juliette Hooper, Grace Qian, Gabrielle Leavitt, Lana Salloum, Gabrielle Ho, Sharvari Mhatre, Michael S. Magaraci, Michael Patterson, Sevile G. Mannickarottu, Saurabh Malani, Jose L. Avalos, Brian Y. Chow, Lukasz J. Bugaj
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The ability to perform sophisticated, high-throughput optogenetic experiments has been greatly enhanced by recent open-source illumination devices that allow independent programming of light patterns in single wells of microwell plates. Howe
Externí odkaz:
https://doaj.org/article/3efa70a4a8c0485dbec94aa00969e823
Autor:
Alexander Chan, Hejia Henry Wang, Rebecca M. Haley, Cindy Song, David Gonzalez-Martinez, Lukasz Bugaj, Michael J. Mitchell, Andrew Tsourkas
Publikováno v:
Mol Pharm
The ability to deliver small protein scaffolds intracellularly could enable the targeting and inhibition of many therapeutic targets that are not currently amenable to inhibition with small-molecule drugs. Here, we report the engineering of small pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446d9b347bc0bc9a3e11d1b1a890bfc8
https://pubmed.ncbi.nlm.nih.gov/35225618
https://pubmed.ncbi.nlm.nih.gov/35225618
Autor:
Jose R. Pinto, Tiago Veltri, Maicon Landim-Vieira, Michelle S. Parvatiyar, David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Clara A. Michell, David Dweck, Andrew P. Landstrom, P. Bryant Chase
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Mutations in TNNC1—the gene encoding cardiac troponin C (cTnC)—that have been associated with hypertrophic cardiomyopathy (HCM) and cardiac dysfunction may also affect Ca2+-regulation and function of slow skeletal muscle since the same gene is ex
Externí odkaz:
https://doaj.org/article/de0f01d82986440e8a1a28beedc74a76
Autor:
Thomas R. Mumford, Diarmid Rae, Abbas Idris, David Gonzalez-Martinez, Ayush Aditya Pal, Lukasz J. Bugaj
Protein clustering plays numerous roles in cell physiology and disease. However, protein oligomers can be difficult to detect because they are often small and fall below the detection limits of conventional fluorescence microscopy. Existing technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::382bd95fd15527a4aee4691e9a6d4fed
https://doi.org/10.1101/2022.07.13.499962
https://doi.org/10.1101/2022.07.13.499962
Autor:
Saachi Datta, William Benman, David Gonzalez-Martinez, Gloria Lee, Juliette Hooper, Grace Qian, Gabrielle Leavitt, Lana Salloum, Gabrielle Ho, Sharvari Mhatre, Michael S. Magaraci, Michael Patterson, Sevile G. Mannickarottu, Saurabh Malani, Jose L. Avalos, Brian Y. Chow, Lukasz J. Bugaj
The ability to perform sophisticated, high-throughput optogenetic experiments has been greatly enhanced by recent open-source illumination devices that allow independent programming of light patterns in single wells of microwell plates. However, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::258f4b0b97e930efc6a21365e2e1651d
https://doi.org/10.1101/2022.07.13.499906
https://doi.org/10.1101/2022.07.13.499906
Autor:
Lukasz Bugaj, David Gonzalez-Martinez, Lee Roth, Thomas Mumford, Juan Guan, Bo Huang, Asmin Tulpule, Trever G. Bivona
Drug resistance remains a central challenge towards durable cancer therapy, including for cancers driven by the EML4-ALK oncogene. EML4-ALK and related fusion oncogenes form cytoplasmic protein condensates that transmit oncogenic signals through the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34ddf42a74ad0094ac0f0503d1abb29
https://doi.org/10.1101/2022.02.02.478845
https://doi.org/10.1101/2022.02.02.478845
Autor:
Silvina Bakardzhleva, Luis Cardo Jalón, Florent Diverchy, David Dreyer Lassen, Wieteke Dupain, Paolo Garonna, Christoph Gerlinger, David Gonzalez Martinez, Emmanuel Letouzé, Mart Mägi, Geta Mitrea, Felicia Pelagalli, Dominik Rozkrut, Geert Somers, Kaisa Vent, Stefaan Verhulst, Erik Wetter, Susanna Zaccarin, Dimitris Zissis
The High-Level Expert Group on facilitating the use of new data sources for official statistics has been created in the context of the data and digital strategy of the European Commission (EC). The task of the Expert Group is to provide recommendatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5dac28eb02e22de10f3ed237b3605f37
https://hdl.handle.net/11368/3026864
https://hdl.handle.net/11368/3026864