Výsledky vyhledávání - "David Gomez Jimenez"

Akademický článek

Early Pharmacodynamic Changes Measured Using RNA Sequencing of Peripheral Blood from Patients in a Phase I Study with Mitazalimab, a Potent CD40 Agonistic Monoclonal Antibody

Autor: Hampus Andersson, Aastha Sobti, David Gomez Jimenez, Yago Pico de Coaña, Sumeet Vijay Ambarkhane, Karin Hägerbrand, Karin Enell Smith, Malin Lindstedt, Peter Ellmark

Publikováno v: Cells, Vol 12, Iss 19, p 2365 (2023)

CD40-targeting therapies can enhance the dendritic cell priming of tumor-specific T cells and repolarize intratumoral macrophages to alleviate the tumoral immunosuppressive environment and remodel the extracellular matrix. Mitazalimab is a potent ago

Externí odkaz: https://doaj.org/article/a7afa486b011446eac4b1806acb30e5d

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Akademický článek

Single-cell analysis of myeloid cells in HPV+ tonsillar cancer

Autor: David Gomez Jimenez, Can Altunbulakli, Sabine Swoboda, Aastha Sobti, David Askmyr, Ashfaq Ali, Lennart Greiff, Malin Lindstedt

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

The incidence of human papillomavirus-positive (HPV+) tonsillar cancer has been sharply rising during the last decades. Myeloid cells represent an appropriate therapeutic target due to their proximity to virus-infected tumor cells, and their ability

Externí odkaz: https://doaj.org/article/76fdc44226b14951b4023306c4ba5317

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Akademický článek

Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)

Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen pr

Externí odkaz: https://doaj.org/article/3ded16f9cf504c5983b33e362b58d5fd

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Akademický článek

Subpopulations of Organoid-Forming Cells Have Different Motility

Autor: David Gomez Jimenez, Sofia Carreira Santos, Lennart Greiff, Kersti Alm, Malin Lindstedt

Publikováno v: Applied Sciences, Vol 10, Iss 13, p 4673 (2020)

Cancer stem cells from oropharyngeal squamous cell carcinoma (OPSCC) have the ability to self-renew and differentiate into heterogeneous three-dimensional structures carrying features of tumor cells. Here, we describe a simple and label-free method f

Externí odkaz: https://doaj.org/article/8eb928bb56de4014a65647511a5a8649

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Abstract 2939: ATOR-4066, a Neo-X-Prime bispecific antibody targeting CD40 and CEA, activates myeloid cells in primary human tumors in vitro and induces anti-tumor immunity in vivo

Autor: Karin Hägerbrand, Anette Sundstedt, Mattias Levin, Yago Pico de Coaña, Laura Varas, Lill Ljung, Anneli Nilsson, Mona Celander, David Gomez Jimenez, Hampus Andersson, Malin Lindstedt, Peter Ellmark

Publikováno v: Cancer Research. 83:2939-2939

Alligator’s Neo-X-Prime platform aims to enable antigen presenting cells to efficiently enhance priming of tumor neoantigen-specific T cells. We have demonstrated that binding of a CD40 x TAA bispecific antibody (bsAb) to CD40 on dendritic cells (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0c7af65c545d4bfc779505d1da165c0
https://doi.org/10.1158/1538-7445.am2023-2939

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Abstract A40: Restoring tumor immunogenicity with dendritic cell reprogramming

Publikováno v: Cancer Immunology Research. 10:A40-A40

Immunotherapy is revolutionizing cancer treatment, but success is limited to a fraction of patients. Tumor immunosurveillance and immunotherapy relies on presentation of tumor-associated antigens by conventional dendritic cells type 1 (cDC1). However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e073e501e2789a159dfdca125d61667
https://doi.org/10.1158/2326-6074.tumimm22-a40

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Pattern recognition receptor expression and maturation profile of dendritic cell subtypes in human tonsils and lymph nodes

Autor: David Gomez Jimenez, David Askmyr, Kristina Lundberg, Lennart Greiff, Milad Abolhalaj, Malin Lindstedt

Publikováno v: Human immunology. 82(12)

Dendritic cells (DCs) with capacity of antigen cross-presentation are of key interest for immunotherapy against cancer as they can induce antigen-specific cytotoxic T lymphocyte (CTL) responses. This study describes frequencies of DC subtypes in huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed228fd0d6cf9a88defe265874da65e
https://pubmed.ncbi.nlm.nih.gov/34511272

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